Patents by Inventor Gary M. Silver

Gary M. Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Carboxylesterase Nucleic Acid Molecules, Proteins and Uses Thereof
    Publication number: 20090170146
    Abstract: The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 2, 2009
    Inventors: Gary M. Silver, Nancy Wisnewski, Kevin S. Brandt
  • Novel carboxylesterase nucleic acid molecules, proteins and uses thereof
    Publication number: 20040081998
    Abstract: The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 29, 2004
    Inventors: Gary M. Silver, Nancy Wisnewski, Kevin S. Brandt
  • Carboxylesterase nucleic acid molecules, proteins and uses thereof
    Patent number: 6664090
    Abstract: The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: December 16, 2003
    Assignee: Heska Corporation
    Inventors: Gary M. Silver, Nancy Wisnewski, Kevin S. Brandt
  • Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides
    Patent number: 6506784
    Abstract: The present invention is directed to inhibiting pest GABA receptors by contacting said receptors with a compound of Formula I: The invention is also directed to methods of controlling pests, especially insects and arachnids such as fleas and ticks, and to novel compounds within the scope of Formula I.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: January 14, 2003
    Assignees: 3-Dimensional Pharmaceuticals, Inc., Heska Corporation
    Inventors: Daljit S. Dhanoa, Dario Doller, Sanath Meegalla, Richard M. Soll, Dimitris Agrafiotis, Nancy Wisnewski, Gary M. Silver, Dan T. Stinchcomb, R. Lee Seward
  • Serine protease inhibitor nucleic acid molecules and uses thereof
    Patent number: 6479253
    Abstract: The present invention relates to flea serine protease inhibitor proteins; to flea serine protease inhibitor nucleic acid molecules, including those that encode such serine protease inhibitor proteins; to antibodies raised against such serine protease inhibitor proteins; and to compounds that inhibit flea serine protease inhibitor activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous ectoparasite infestation.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: November 12, 2002
    Assignee: Heska Corporation
    Inventors: Gary M. Silver, Nancy Wisnewski
  • Flea serine protease inhibitor proteins
    Patent number: 6372887
    Abstract: The present invention relates to flea serine protease inhibitor proteins; to flea serine protease inhibitor nucleic acid molecules, including those that encode such serine protease inhibitor proteins; to antibodies raised against such serine protease inhibitor proteins; and to compounds that inhibit flea serine protease inhibitor activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous ectoparasite infestation.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: April 16, 2002
    Assignee: Heska Corporation
    Inventors: Gary M. Silver, Nancy Wisnewski
  • Anti-flea epoxide hydrolase antibodies and uses thereof
    Patent number: 6290958
    Abstract: The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: September 18, 2001
    Assignee: Heska Corporation
    Inventors: Nancy Wisnewski, Gary M. Silver, Katherine Callies Lo, Kevin S. Brandt
  • Carboxylesterase nucleic acid molecules and uses thereof
    Patent number: 6291222
    Abstract: The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: September 18, 2001
    Assignee: Heska Corporation
    Inventors: Gary M. Silver, Nancy Wisnewski
  • Flea epoxide hydrolase proteins and uses thereof
    Patent number: 6153397
    Abstract: The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: November 28, 2000
    Assignee: Heska Corporation
    Inventors: Nancy Wisnewski, Gary M. Silver, Katherine Callies Lo, Kevin S. Brandt
  • Flea epoxide hydrolase nucleic acid molecules, proteins and uses thereof
    Patent number: 6143542
    Abstract: The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: November 7, 2000
    Assignee: Heska Corporation
    Inventors: Nancy Wisnewski, Gary M. Silver, Katherine Callies Lo, Kevin S. Brandt
  • Carboxylesterase nucleic acid molecules, proteins and uses thereof
    Patent number: 6063610
    Abstract: The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: May 16, 2000
    Assignee: Heska Corporation
    Inventors: Gary M. Silver, Nancy Wisnewski
  • Flea epoxide hydrolase nucleic acid molecules, proteins and uses thereof
    Patent number: 6037160
    Abstract: The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: March 14, 2000
    Assignee: Heska Corporation
    Inventors: Nancy Wisnewski, Gary M. Silver, Katherine Cailles Lo, Kevin S. Brandt