Abstract: Ink cleaning compositions are disclosed which degrade or solubilize broad classes of printing ink residues on printing screens for quick removal by a pressurized water stream. The compositions are essentially non-aqueous and contain N-methyl-2-pyrrolidone (NMP), an oxygenated solvent, such as butyl cellosolve and cyclohexanone, and a surfactant. Alternatingly, compositions containing NMP and tetrahydrofurfuryl alcohol as the primary components are disclosed. Methods of cleaning and reclaiming printing screens which provide synergistic activities are also disclosed. The compositions meet health and safety standards due to their biodegradability, lack of flammability and high threshold limit values.