Abstract: Systems, apparatus, and methods of rendering content based on a control point of a camera device are disclosed. In an example, a marker is attached to the camera device and its pose is tracked over time. Based on a camera model of the camera device, an offset between the marker and the control point is determined. The tracked pose of the marker can be translated and/or rotated according to the offset to estimate a pose of the control point. The rendering of the content is adjusted over time based on the estimated poses of the control point. Upon presentation of the content in a real-world space (e.g., on a display assembly located therein), the camera device can capture the content along with other objects of the real-world space and generate a video stream thereof.

Abstract: Systems, apparatus, and methods of rendering content based on a control point of a camera device are disclosed. In an example, a marker is attached to the camera device and its pose is tracked over time. Based on a camera model of the camera device, an offset between the marker and the control point is determined. The tracked pose of the marker can be translated and/or rotated according to the offset to estimate a pose of the control point. The rendering of the content is adjusted over time based on the estimated poses of the control point. Upon presentation of the content in a real-world space (e.g., on a display assembly located therein), the camera device can capture the content along with other objects of the real-world space and generate a video stream thereof.

Abstract: Systems, apparatus, and methods for rendering content based on display assembly pose are disclosed. In an example, motion capture data of a display of a plurality of displays is received, the display moving from a first physical pose to a second physical pose. The motion capture data is processed to determine the coordinates of the second physical pose. A transformation of the second physical pose of the display to a virtual pose of the display is generated. A virtual model of the plurality of displays is updated, the virtual model comprising the virtual pose of the display. The content is rendered on the updated virtual model.

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

Abstract: A distributed studio management system includes a computing system having a computer readable memory and a processor. The computing system is associated with a first production facility that is remote to a second production facility. The processor is configured to perform the operations of receiving a set of device commands having commands targeting first and second devices in the first production facility and where the set of device commands are related to the second production facility, enqueuing a first command from the device commands into a first command queue assigned to the first device and a second command from the device commands into a second command queue assigned to the second device according to each device command's synchronized execution times, and causing the first and second devices to execute commands from their respective command queues relative to each other according to the commands' respective synchronized execution times.

Abstract: A content production management system within a distributed studio environment includes a command interface module and a command queue management module. The command interface module is configured to render a user interface for a set of content production entities associated with a set of content production volumes within the distributed studio environment. The command queue management module, upon execution of software instructions, is configured to perform the operations of receiving, from the command interface module, a command targeting a target content production entity, assigning a synchronized execution time to the command, enqueueing the command into a command queue associated with the target content production entity according to the synchronized execution time, and enabling the target content production entity to execute the command from the command queue according to the synchronized execution time.

Abstract: A content production management system within a distributed studio environment includes a command interface module and a command queue management module. The command interface module is configured to render a user interface for a set of content production entities associated with a set of content production volumes within the distributed studio environment. The command queue management module, upon execution of software instructions, is configured to perform the operations of receiving, from the command interface module, a command targeting a target content production entity, assigning a synchronized execution time to the command, enqueueing the command into a command queue associated with the target content production entity according to the synchronized execution time, and enabling the target content production entity to execute the command from the command queue according to the synchronized execution time.

Abstract: The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrroll-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

Abstract: The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

Abstract: The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.

Abstract: An apparatus for gas and solids separation from down-hole fluids having an inner tube and an outer tube disposed about the inner tube. The annular region between the tubes contain a plurality of chambers, separated by fluid barriers. The chambers include an intake chamber to receive fluids from outside of the outer tube through an orifice, and processing chambers. Fluid communication between the intake and processing chambers is restricted to fluid flow through sets of tubes. Fluid communication between a lowermost processing chamber below the intake chamber and a lower processing chamber above the intake chamber is restricted to fluid flow through the inner tube. A block restricts fluid communication within the inner tube to other chambers above the intake chamber. Orifices in the inner tube of the processing chambers on either side of the block provide fluid communication across the block.

Abstract: An apparatus, methods and systems for multi-configuration, multi-stage gas-liquid separation are presented. A production string is fitted with a shroud of size similar to the collars. Gaseous fluids intake into the upper portion of the shroud into a first chamber. Tubes or pipes collect the fluids for transport into the lower portion of a receiving chamber. Another plurality of tubes collect fluids in the portion of the receiving chamber above the first set for transport into a third chamber. Separated gases are collected and disposed. One or more receiving chambers are used. A final set of tubes or pipes transport the processed fluid to the bottom portion of a final chamber for delivery into the production string. The final chamber may be fitted with material-packed cylinders for further gas separation prior to delivery. The material-packed cylinders may be used alone as separators, or in combination with the receiving chambers.