Patents by Inventor Gary Mitchell
Gary Mitchell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12139499Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: GrantFiled: June 25, 2019Date of Patent: November 12, 2024Assignee: PTC THERAPEUTICS, INC.Inventors: Nanjing Zhang, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Guangming Chen, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Nadiya Sydorenko, Anthony Turpoff, Matthew G. Woll, Wuming Yan
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Publication number: 20240336613Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: ApplicationFiled: July 29, 2022Publication date: October 10, 2024Inventors: Suresh BABU, Rauful ALAM, Anuradha BHATTACHARYYA, Guangming CHEN, Matthew S. EASTWOOD, Seyedmorteza HOSSEYNI, Yao JIANG, Gary Mitchell KARP, Young-Choon MOON, Jana NARASIMHAN, Hongyu REN, Nadiya SYDORENKO, Matthew G. WOLL, Nanjing ZHANG
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Patent number: 12034800Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a central database where servers within a server group identified by a group name may post unique identifiers (UIDs) for retrieval and reposting by group clients configured with the group name, which may query the central database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall posture as determined by the group client. In some embodiments, one server of the group is a “dummy server” that may aggregate and selectively transmit server information from other servers in the group, or other devices, and post it to the central database. The methods described herein eliminate a separate controller and thereby a single point of failure (SPOF).Type: GrantFiled: September 12, 2022Date of Patent: July 9, 2024Assignee: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Patent number: 12034799Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a central database where servers within a server group identified by a group name may post unique identifiers (UIDs) for retrieval by group clients configured with the group name, which may query the central database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall availability profile as determined by the group client. In some embodiments, one server of the group is a “dummy server” that may aggregate and selectively transmit server information from other servers in the group, or other devices, and posts it to the central database for client access. The methods described herein eliminate a separate controller and thereby a single point of failure (SPOF).Type: GrantFiled: September 12, 2022Date of Patent: July 9, 2024Assignee: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Publication number: 20240132509Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.Type: ApplicationFiled: November 13, 2023Publication date: April 25, 2024Inventors: Nadiya Sydorenko, Md Rauful Alam, Michael A. Arnold, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Aleksey I. Gerasyuto, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Matthew G. Woll, Wuming Yan, Nanjing Zhang
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Publication number: 20240067646Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.Type: ApplicationFiled: July 26, 2023Publication date: February 29, 2024Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
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Patent number: 11858941Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: GrantFiled: June 25, 2019Date of Patent: January 2, 2024Assignee: PTC THERAPEUTICS, INC.Inventors: Nadiya Sydorenko, Md Rauful Alam, Michael A. Arnold, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Aleksey I. Gerasyuto, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Matthew G. Woll, Wuming Yan, Nanjing Zhang
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Patent number: 11799690Abstract: The invention is that of systems and methods for communications between one or more networks and subsequently network devices configured with a networking application for processing network based communications when the devices are on different logical and physical networks. The methods herein involve translation of remote IP addresses of LAN devices to addresses comprising headend network prefixes, to allow for LAN extension of remote to headend networks and communications between devices on the disparate networks. Data packets from a remote LAN interface are transferred to an outbound interface once translated, then forwarded via a formed bridged tunnel link to a headend network device. A server comprising a local LAN and outbound interface is further configured with a NAT module for IP address translation and an optional security module for additional authenticity verification of remote devices attempting to penetrate the headend network.Type: GrantFiled: February 10, 2021Date of Patent: October 24, 2023Assignee: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Publication number: 20230331725Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: ApplicationFiled: June 16, 2023Publication date: October 19, 2023Inventors: Nadiya Sydorenko, Md Rauful Alam, Lukiana Amedzo, Suresh Babu, Ramil Y. Baiazitov, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Nathaniel T. Kenton, Anthony R. Mazzotti, Young-Choon Moon, Nicholas W. Mszar, Jana Narasimhan, Sudipta Pal, Jigar S. Patel, Anthony Turpoff, Matthew G. Woll, Zhenrong Xu, Nanjing Zhang
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Patent number: 11780839Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: GrantFiled: March 27, 2019Date of Patent: October 10, 2023Assignee: PTC THERAPEUTICS, INC.Inventors: Nadiya Sydorenko, Md Rauful Alam, Lukiana Amedzo, Suresh Babu, Ramil Y. Baiazitov, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Nathaniel T. Kenton, Anthony R. Mazzotti, Young-Choon Moon, Nicholas W. Mszar, Jana Narasimhan, Sudipta Pal, Jigar S. Patel, Anthony Turpoff, Matthew G. Woll, Zhenrong Xu, Nanjing Zhang
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Patent number: 11753407Abstract: Provided herein are compounds of Formula (I): and forms thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein, including compositions thereof and uses therewith for treating spinal muscular atrophy.Type: GrantFiled: October 5, 2020Date of Patent: September 12, 2023Assignees: PTC Therapeutics, Inc., F. Hoffmann-La Roche AGInventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Yurpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
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Publication number: 20230234942Abstract: The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: ApplicationFiled: April 8, 2021Publication date: July 27, 2023Inventors: Nadiya Sydorenko, Rauful Alam, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Matteo Chierchia, Gary Mitchell Karp, Tom Tuan Luong, Anthony R. Mazzotti, Young-Choon Moon, Nicholas Walter Mszar, Jana Narasimhan, Jigar S. Patel, Hongyu Ren, Gang Wang, Matthew G. Woll, Nanjing Zhang, Xiaoyan Zhang
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Patent number: 11685746Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), Formula (II), Formula (III), or Formula (IV), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: GrantFiled: June 25, 2019Date of Patent: June 27, 2023Assignee: PTC Therapeutics, Inc.Inventors: Guangming Chen, Anuradha Bhattacharyya, Yao Jiang, Gary Mitchell Karp, Jana Narasimhan, Anthony Turpoff, Nanjing Zhang
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Publication number: 20230057568Abstract: The present description relates to compounds useful for improving pre-mRNA splicing in a cell. In particular, another aspect of the present description relates to substituted thieno [3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.Type: ApplicationFiled: December 7, 2020Publication date: February 23, 2023Applicant: PTC THERAPEUTICS, INC.Inventors: Nanjing ZHANG, Michael A. ARNOLD, Amal DAKKA, Gary Mitchell KARP, Tom Tuan LUONG, Christie MORRILL, Jana NARASIMHAN, Nikolai A. NARYSHKIN, Anthony TURPOFF, Jiashi WANG, Xiaoyan ZHANG
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Patent number: 11477276Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a server database where servers within a server group identified by a groupname may post unique identifiers (UIDs) for retrieval by group clients configured with the groupname, which may query the server database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall availability profile as determined by the group client. The methods described herein eliminate a separate controller and thereby eliminate the single point of failure (SPOF) represented by connection controllers and load balancers in a network as are common in the current state of the art.Type: GrantFiled: February 24, 2021Date of Patent: October 18, 2022Assignee: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Publication number: 20220278960Abstract: The invention is that of systems and methods to reduce or eliminate network resource exposure to unauthorized network users. The methods described herein are designed to only permit authenticated remote network device access to central network services based on the content of requests from remote network devices seeking access. A system as described herein is configured with conditional access grantor and request modules located on central and remote networks, respectively. A conditional access grantor module dynamically configures a central network firewall or equivalent to permit or deny access from the specific devices on the remote network. A database is provided for storing of remote device details or parameters supplied by the grantor module and required for connection thereby to the central network.Type: ApplicationFiled: February 26, 2021Publication date: September 1, 2022Applicant: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Publication number: 20220272147Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a server database where servers within a server group identified by a groupname may post unique identifiers (UIDs) for retrieval by group clients configured with the groupname, which may query the server database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall availability profile as determined by the group client. The methods described herein eliminate a separate controller and thereby eliminate the single point of failure (SPOF) represented by connection controllers and load balancers in a network as are common in the current state of the art.Type: ApplicationFiled: February 24, 2021Publication date: August 25, 2022Applicant: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Publication number: 20220255930Abstract: The invention is that of systems and methods for communications between one or more networks and subsequently network devices configured with a networking application for processing network based communications when the devices are on different logical and physical networks. The methods herein involve translation of remote IP addresses of LAN devices to addresses comprising headend network prefixes, to allow for LAN extension of remote to headend networks and communications between devices on the disparate networks. Data packets from a remote LAN interface are transferred to an outbound interface once translated, then forwarded via a formed bridged tunnel link to a headend network device. A server comprising a local LAN and outbound interface is further configured with a NAT module for IP address translation and an optional security module for additional authenticity verification of remote devices attempting to penetrate the headend network.Type: ApplicationFiled: February 10, 2021Publication date: August 11, 2022Applicant: IP Technology Labs, LLCInventors: Gary Mitchell, Scott Whittle, Kurt Quasebarth
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Publication number: 20220251098Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: ApplicationFiled: April 18, 2022Publication date: August 11, 2022Inventors: Matthew G. Woll, Lukiana Amedzo, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Anthony R. Mazzotti, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Zhenrong Xu
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Patent number: 11407753Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.Type: GrantFiled: June 5, 2018Date of Patent: August 9, 2022Assignee: PTC THERAPEUTICS, INC.Inventors: Matthew G. Woll, Lukiana Amedzo, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Anthony R. Mazzotti, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Zhenrong Xu