Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: A portable steam generator includes a power source in a housing, a water tank in the housing, a heating element in the housing and configured to heat water in the water tank to produce steam using power from the power source, and a track on the housing configured to support the portable steam generator in an installation position and allow manual removal from the installation position. A pre-plumbed integrated bathroom panel includes a plumbing inlet configured to provide water to the panel, a water outlet connected to the plumbing inlet, a steam outlet connected to the plumbing inlet and a heating element, a sanitizing outlet connected to the plumbing inlet and an additive generator, valves for directing water from the plumbing inlet to the at least one water outlet, the at least one steam outlet, and the at least one sanitizing outlet, and a controller configured to operate at least the plurality of valves.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The invention is that of systems and methods for communications between one or more networks and subsequently network devices configured with a networking application for processing network based communications when the devices are on different logical and physical networks. The methods herein involve translation of remote IP addresses of LAN devices to addresses comprising headend network prefixes, to allow for LAN extension of remote to headend networks and communications between devices on the disparate networks. Data packets from a remote LAN interface are transferred to an outbound interface once translated, then forwarded via a formed bridged tunnel link to a headend network device. A server comprising a local LAN and outbound interface is further configured with a NAT module for IP address translation and an optional security module for additional authenticity verification of remote devices attempting to penetrate the headend network.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: Provided herein are compounds of Formula (I): and forms thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), Formula (II), Formula (III), or Formula (IV), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The present description relates to compounds useful for improving pre-mRNA splicing in a cell. In particular, another aspect of the present description relates to substituted thieno [3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.

Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a central database where servers within a server group identified by a group name may post unique identifiers (UIDs) for retrieval by group clients configured with the group name, which may query the central database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall availability profile as determined by the group client. In some embodiments, one server of the group is a “dummy server” that may aggregate and selectively transmit server information from other servers in the group, or other devices, and posts it to the central database for client access. The methods described herein eliminate a separate controller and thereby a single point of failure (SPOF).

Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a central database where servers within a server group identified by a group name may post unique identifiers (UIDs) for retrieval and reposting by group clients configured with the group name, which may query the central database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall posture as determined by the group client. In some embodiments, one server of the group is a “dummy server” that may aggregate and selectively transmit server information from other servers in the group, or other devices, and post it to the central database. The methods described herein eliminate a separate controller and thereby a single point of failure (SPOF).

Abstract: The invention is that of systems and methods for controllerless and distributed network connections to servers on a network by remote clients seeking their services. The invention comprises a server database where servers within a server group identified by a groupname may post unique identifiers (UIDs) for retrieval by group clients configured with the groupname, which may query the server database for server connection information such as uptime, downtime, and congestion in order to select a server for a preferential connection based on an overall availability profile as determined by the group client. The methods described herein eliminate a separate controller and thereby eliminate the single point of failure (SPOF) represented by connection controllers and load balancers in a network as are common in the current state of the art.

Abstract: The invention is that of systems and methods to reduce or eliminate network resource exposure to unauthorized network users. The methods described herein are designed to only permit authenticated remote network device access to central network services based on the content of requests from remote network devices seeking access. A system as described herein is configured with conditional access grantor and request modules located on central and remote networks, respectively. A conditional access grantor module dynamically configures a central network firewall or equivalent to permit or deny access from the specific devices on the remote network. A database is provided for storing of remote device details or parameters supplied by the grantor module and required for connection thereby to the central network.