Patents by Inventor Gary Mitchell Karp

Gary Mitchell Karp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for treating Huntington's disease
    Patent number: 12577226
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), Formula (II), or Formula (III), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: March 17, 2026
    Assignee: PTC Therapeutics, Inc.
    Inventors: Nadiya Sydorenko, Rauful Alam, Lukiana Amedzo, Michael A. Arnold, Suresh Babu, Anuradha Bhattacharyya, Gary Mitchell Karp, Nathaniel T. Kenton, Tom Tuan Luong, Anthony R. Mazzotti, Young-Choon Moon, Christie Morrill, Nicholas Walter Mszar, Jana Narasimhan, Jigar S. Patel, Hongyu Ren, Anthony Turpoff, Gang Wang, Matthew G. Woll, Nanjing Zhang, Xiaoyan Zhang
  • HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20260028347
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: September 30, 2025
    Publication date: January 29, 2026
    Inventors: Nadiya SYDORENKO, Md Rauful ALAM, Michael A. ARNOLD, Suresh BABU, Anuradha BHATTACHARYYA, Guangming CHEN, Aleksey I. GERASYUTO, Gary Mitchell KARP, Andrew J. KASSICK, Anthony R. MAZZOTTI, Young-Choon MOON, Jana NARASIMHAN, Jigar PATEL, Anthony TURPOFF, Matthew G. WOLL, Wuming YAN, Nanjing ZHANG
  • Substituted pyrrolo [2,3-d]pyrimidines for treating familial dysautonomia
    Patent number: 12398140
    Abstract: The present description relates to compounds of formula (I) useful for improving pre-mRNA splicing in a cell. In particular, another aspect described herein relates to substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: August 26, 2025
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Jiashi Wang, Michael A. Arnold, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai A. Naryshkin, Nanjing Zhang
  • Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia
    Patent number: 12384797
    Abstract: The present description relates' to compounds of formula (I) useful for improving pre-mRNA splicing in a cell. In particular, another aspect of the present description relates to substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: August 12, 2025
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Nanjing Zhang, Michael A. Arnold, Amal Dakka, Gary Mitchell Karp, Tom Tuan Luong, Jana Narasimhan, Nikolai A. Naryshkin, Jiashi Wang, Xiaoyan Zhang
  • Compounds for treating Huntington's disease
    Patent number: 12384789
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: August 12, 2025
    Assignee: PTC Therapeutics, Inc.
    Inventors: Matthew G. Woll, Lukiana Amedzo, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Anthony R. Mazzotti, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Zhenrong Xu
  • Heteroaryl compounds for treating Huntington's disease
    Patent number: 12139499
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: November 12, 2024
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Nanjing Zhang, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Guangming Chen, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Nadiya Sydorenko, Anthony Turpoff, Matthew G. Woll, Wuming Yan
  • HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20240336613
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: July 29, 2022
    Publication date: October 10, 2024
    Inventors: Suresh BABU, Rauful ALAM, Anuradha BHATTACHARYYA, Guangming CHEN, Matthew S. EASTWOOD, Seyedmorteza HOSSEYNI, Yao JIANG, Gary Mitchell KARP, Young-Choon MOON, Jana NARASIMHAN, Hongyu REN, Nadiya SYDORENKO, Matthew G. WOLL, Nanjing ZHANG
  • HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20240132509
    Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.
    Type: Application
    Filed: November 13, 2023
    Publication date: April 25, 2024
    Inventors: Nadiya Sydorenko, Md Rauful Alam, Michael A. Arnold, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Aleksey I. Gerasyuto, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Matthew G. Woll, Wuming Yan, Nanjing Zhang
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20240067646
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: July 26, 2023
    Publication date: February 29, 2024
    Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
  • METHODS FOR TREATING SPINOCEREBELLAR ATAXIA TYPE 3
    Publication number: 20240051968
    Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.
    Type: Application
    Filed: February 2, 2022
    Publication date: February 15, 2024
    Applicant: PTC Therapeutics, Inc.
    Inventors: GAYAN MIRIHANA ARACHCHILAGE, MICHAEL A. ARNOLD, SCOTT BARRAZA, ANURADHA BHATTACHARYYA, GARY MITCHELL KARP
  • METHODS FOR TREATING SPINOCEREBELLAR ATAXIA TYPE 3
    Publication number: 20240043444
    Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.
    Type: Application
    Filed: February 2, 2022
    Publication date: February 8, 2024
    Applicant: PTC Therapeutics, Inc.
    Inventors: GAYAN MIRIHANA ARACHCHILAGE, MICHAEL A. ARNOLD, SCOTT BARRAZA, ANURADHA BHATTACHARYYA, GARY MITCHELL KARP
  • METHODS FOR TREATING SPINOCEREBELLAR ATAXIA TYPE 3
    Publication number: 20240041886
    Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.
    Type: Application
    Filed: February 2, 2022
    Publication date: February 8, 2024
    Applicant: PTC Therapeutics, Inc.
    Inventors: GAYAN MIRIHANA ARACHCHILAGE, MICHAEL A. ARNOLD, SCOTT BARRAZA, ANURADHA BHATTACHARYYA, GARY MITCHELL KARP
  • Heterocyclic and heteroaryl compounds for treating Huntington's disease
    Patent number: 11858941
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: January 2, 2024
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Nadiya Sydorenko, Md Rauful Alam, Michael A. Arnold, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Aleksey I. Gerasyuto, Gary Mitchell Karp, Andrew J. Kassick, Anthony R. Mazzotti, Young-Choon Moon, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Matthew G. Woll, Wuming Yan, Nanjing Zhang
  • COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20230331725
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: June 16, 2023
    Publication date: October 19, 2023
    Inventors: Nadiya Sydorenko, Md Rauful Alam, Lukiana Amedzo, Suresh Babu, Ramil Y. Baiazitov, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Nathaniel T. Kenton, Anthony R. Mazzotti, Young-Choon Moon, Nicholas W. Mszar, Jana Narasimhan, Sudipta Pal, Jigar S. Patel, Anthony Turpoff, Matthew G. Woll, Zhenrong Xu, Nanjing Zhang
  • Compounds for treating Huntington's disease
    Patent number: 11780839
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 10, 2023
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Nadiya Sydorenko, Md Rauful Alam, Lukiana Amedzo, Suresh Babu, Ramil Y. Baiazitov, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Nathaniel T. Kenton, Anthony R. Mazzotti, Young-Choon Moon, Nicholas W. Mszar, Jana Narasimhan, Sudipta Pal, Jigar S. Patel, Anthony Turpoff, Matthew G. Woll, Zhenrong Xu, Nanjing Zhang
  • Compounds for treating spinal muscular atrophy
    Patent number: 11753407
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: September 12, 2023
    Assignees: PTC Therapeutics, Inc., F. Hoffmann-La Roche AG
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Yurpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20230234942
    Abstract: The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: April 8, 2021
    Publication date: July 27, 2023
    Inventors: Nadiya Sydorenko, Rauful Alam, Suresh Babu, Anuradha Bhattacharyya, Guangming Chen, Matteo Chierchia, Gary Mitchell Karp, Tom Tuan Luong, Anthony R. Mazzotti, Young-Choon Moon, Nicholas Walter Mszar, Jana Narasimhan, Jigar S. Patel, Hongyu Ren, Gang Wang, Matthew G. Woll, Nanjing Zhang, Xiaoyan Zhang
  • Heteroaryl compounds for treating Huntington's disease
    Patent number: 11685746
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), Formula (II), Formula (III), or Formula (IV), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: June 27, 2023
    Assignee: PTC Therapeutics, Inc.
    Inventors: Guangming Chen, Anuradha Bhattacharyya, Yao Jiang, Gary Mitchell Karp, Jana Narasimhan, Anthony Turpoff, Nanjing Zhang
  • COMPOUNDS FOR TREATING FAMILIAL DYSAUTONOMIA
    Publication number: 20230057568
    Abstract: The present description relates to compounds useful for improving pre-mRNA splicing in a cell. In particular, another aspect of the present description relates to substituted thieno [3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.
    Type: Application
    Filed: December 7, 2020
    Publication date: February 23, 2023
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Nanjing ZHANG, Michael A. ARNOLD, Amal DAKKA, Gary Mitchell KARP, Tom Tuan LUONG, Christie MORRILL, Jana NARASIMHAN, Nikolai A. NARYSHKIN, Anthony TURPOFF, Jiashi WANG, Xiaoyan ZHANG
  • COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20220251098
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Application
    Filed: April 18, 2022
    Publication date: August 11, 2022
    Inventors: Matthew G. Woll, Lukiana Amedzo, Suresh Babu, Scott J. Barraza, Anuradha Bhattacharyya, Gary Mitchell Karp, Anthony R. Mazzotti, Jana Narasimhan, Jigar Patel, Anthony Turpoff, Zhenrong Xu