Patents by Inventor Gary Molino
Gary Molino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080233585Abstract: The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.Type: ApplicationFiled: March 13, 2008Publication date: September 25, 2008Inventors: Christopher Burgess, Susan Myerow, Arunthathi Thiagalingam, Peter Maimonis, Gary Molino, Lawrence Burgart, Lisa Allyn Boardman, Stephen Thibodeau, Marcia Lewis
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Publication number: 20080194043Abstract: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1? or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1? or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1? or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.Type: ApplicationFiled: March 21, 2008Publication date: August 14, 2008Inventors: Jon H. ASTLE, Christopher C. BURGESS, Theodore J. CATINO, Poornima DWIVEDI, Maryanne HUNTRESS, Karen Anne JOHNSON, Marcia E. LEWIS, Peter J. MAIMONIS, Gary A. MOLINO, Susan H. MYEROW, Arunthathi THIAGALINGAM, Lisa Allyn BOARDMAN, Lawrence J. BURGART, Stephen N. THIBODEAU, Sheryl BROWN-SHIMER
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Publication number: 20080131889Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: April 30, 2007Publication date: June 5, 2008Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
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Patent number: 7258973Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: GrantFiled: July 17, 2001Date of Patent: August 21, 2007Assignees: Mayo Foundation for Medical Education & Research, Bayer Healthcare, LLCInventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen Thibodeau, Lawrence J. Burgart, Lisa Allyn Boardman
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Patent number: 7211398Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: GrantFiled: October 25, 2002Date of Patent: May 1, 2007Assignees: Bayer Corporation, Mayo Foundation for Medical Education and ResearchInventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen Thibodeau, Lawrence J. Burgart, Lisa Allyn Boardman
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Publication number: 20060188889Abstract: The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.Type: ApplicationFiled: November 4, 2003Publication date: August 24, 2006Inventors: Christopher Burgess, Susan Myerow, Arunthathi Thiagalingam, Peter Maimonis, Gary Molino, Lawrence Burgart, Lisa Boardman, Stephen Thibodeau, Marcia Lewis
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Publication number: 20060179496Abstract: This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: July 26, 2005Publication date: August 10, 2006Inventors: Christopher Burgess, Jon Astle, Eddie Carroll, Theodore Catino, Poornima Dwivedi, Gary Molino, Arunthathi Thiagalingam, Marcia Lewis, Stephen Thibodeau, Lawrence Burgart, Lisa Boardman
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Publication number: 20060134653Abstract: The present invention relates to nucleic acid sequences which are overexpressed in colorectal tumors which display a high level of microsatellite instability (MSI-H) vs. tumors displaying a low level of microsatellite instability (MSS), and can thus be used to identify MSI-H in a patient, and be used further to facilitate patient prognosis, monitor disease progression/regression, identify appropriate treatment regimes, and evaluate the efficacy of treatment.Type: ApplicationFiled: April 13, 2005Publication date: June 22, 2006Inventors: Christopher Burgess, Theodore Catino, Gary Molino, Susan Myerow, Arunthathi Thiagalingam, Marcia Lewis, Stephen Thibodeau, Lisa Boardman, Lawrence Burgart
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Publication number: 20040157278Abstract: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1&agr; or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1&agr; or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1&agr; or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.Type: ApplicationFiled: December 12, 2003Publication date: August 12, 2004Applicants: Bayer Corporation, Mayo Foundation for Medical Education & ResearchInventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Maryanne Huntress, Karen Anne Johnson, Marcia E. Lewis, Peter J. Maimonis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Lisa Allyn Boardman, Lawrence J. Burgart, Stephen N. Thibodeau, Sheryl Brown-Shimer
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Publication number: 20040146879Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: June 30, 2003Publication date: July 29, 2004Applicants: Bayer HealthCare LLC, Mayo Foundation for Medical Education & ResearchInventors: Jon H. Astle, Lisa Allyn Boardman, Lawrence J. Burgart, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen N. Thibodeau
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Publication number: 20040110668Abstract: This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: October 2, 2001Publication date: June 10, 2004Inventors: Christopher C. Burgess, Jon H. Astle, Eddie Carroll, Theodore J. Catino, Poornima Dwivedi, Gary A. Molino, Arunthathi Thiagalingam, Marcia E. Lewis
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Publication number: 20030097666Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: May 31, 2001Publication date: May 22, 2003Inventors: Wilson O. Endege, Kathleen E. Steinmann, Jon H. Astle, Christopher C. Burgess, Eddie Carroll, Theodore J. Catino, Poornima Dwivedi, Donna M. Ford, Marcia E. Lewis, Gary A. Molino, John E. Mohahan, Robert Schlegel
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Publication number: 20030082620Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: October 25, 2002Publication date: May 1, 2003Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
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Publication number: 20020034758Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: July 17, 2001Publication date: March 21, 2002Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
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Patent number: 6262334Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: GrantFiled: August 30, 1999Date of Patent: July 17, 2001Assignee: Bayer CorporationInventors: Wilson O. Endege, Kathleen E. Steinmann, Jon H. Astle, Christopher C. Burgess, Eddie Carroll, III, Theodore J. Catino, Poornima Dwivedi, Donna M. Ford, Marcia E. Lewis, Gary A. Molino, John E. Monahan, Robert Schlegel