Abstract: The present application provides diagnostic methods for determining the fertility status of a male individual by evaluating his DEFB-126 phenotypic and genotypic status. The present invention relates to a dinucleotide deletion polymorphism in the protein coding sequence of a DEFB-126 nucleic acid. The amino acid sequence of this variant has a significantly altered the carboxyl terminal, carbohydrate-containing domain of DEFB-126 in comparison to a wild-type DEFB-126 polypeptide. This variant results in aberrant protein function and structure, leading to reduced sperm function and fertility. The present invention provides methods for analyzing the genotype of individuals with respect to the gene encoding DEFB-126 in order to determine whether that individual has reduced fertility. Such determination will provide an individual knowledge of whether their genotype is associated with a risk of reduced fertility and to allow that individual to receive appropriate fertility treatment options.

Abstract: This invention provides methods, compositions and contraceptive devices that use sulfonated compounds that interact with sperm to inhibit fertilization. Natural contraceptive methods, compositions and contraceptive devices are also included. These natural contraceptives use sulfonated compounds isolated from natural sources. Methods, compositions and contraceptive devices are also provided that use a lignin and/or a derivative thereof.