Abstract: Provided herein are IL-2 muteins that bind to the IL-2 receptor ? subunit but do not have measurable binding to the IL-2 receptor a subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.

Abstract: Various methods and systems such as in a software application are presented which may include automated purchase recommendations based on amalgamated purchase constraints (4) for business inventory maintenance, notation of events through noted event entry portals (31) for business related observation recordation, automatic facilitation of regular debut of initial suggested industry tied information (50), presentation of business performance data (65) and disparate substantially redundant business performance data (67) in a business performance display (66) for a summary review of business operations, and easy selection of inventory items (83) from a recommended hierarchical categorization of inventory items which may be used to create buying reports, ad hoc reports, and the like.