Patents by Inventor Gary N. Zecherle

Gary N. Zecherle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Precursor N-acetylgalactosamine-4 sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20080260715
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: May 18, 2007
    Publication date: October 23, 2008
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Minmin Qin, Gary N. Zecherle, Wai-Pan Chan, Paul A. Fitzpatrick, Stuart Swiedler, John M. Henstrand, Dan J. Wendt, Lin Chen, Christopher M. Starr
  • Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Patent number: 6972124
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: December 6, 2005
    Assignee: BioMarin Pharmaceuticals Inc.
    Inventors: Minmin Qin, Gary N. Zecherle, Wai-Pan Chan, Paul A. Fitzpatrick, Stuart Sweidler, John M. Henstrand, Dan J. Wendt, Lin Chen, Christopher M. Starr
  • Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Patent number: 6866844
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: March 15, 2005
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Minmin Qin, John M. Henstrand, Gary N. Zecherle, Dan J. Wendt, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, Christopher M. Starr
  • Precursor of N-acetylgalactosamine-4-sufatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20040131605
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: November 7, 2003
    Publication date: July 8, 2004
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Minmin Qin, Gary N. Zecherle, Wai-Pan Chan, Paul A. Fitzpatrick, Stuart Sweidler, John M. Henstrand, Dan J. Wendt, Lin Chen, Christopher M. Starr
  • Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
    Publication number: 20040101524
    Abstract: The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
    Type: Application
    Filed: November 7, 2002
    Publication date: May 27, 2004
    Inventors: Minmin Qin, John M. Henstrand, Gary N. Zecherle, Dan J. Wendt, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, Christopher M. Starr
  • Recombinant &agr;-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
    Patent number: 6569661
    Abstract: The present invention provides a recombinant human &agr;-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human &agr;-L-iduronidase enzyme as well as methods to treat certain genetic disorders including &agr;-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 27, 2003
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Minmin Qin, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, John M. Hendstrand, Dan J. Wendt, Gary N. Zecherle, Christopher M. Starr, Emil D. Kakkis
  • Methods for producing and purifying recombinant alpha-L-iduronidase
    Publication number: 20020146802
    Abstract: The present invention provides a recombinant human &agr;-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99%. The present invention further provides large-scale methods to produce and purify commercial grade recombinant human &agr;-L-iduronidase enzyme thereof.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 10, 2002
    Inventors: Minmin Qin, Wai-Pan Chan, Lin Chen, Paul A. Fitzpatrick, John M. Henstrand, Dan J. Wendt, Gary N. Zecherle, Christopher M. Starr, Emil D. Kakkis