Abstract: This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).

Abstract: Some analogues (eg. 3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)pyridin-1-ium, 3-carboxy-1-isopropylpyridin-1-ium, 1-benzyl-3-carbamoylpyridin-1-ium, 3-carbamoyl-1-methylpyridin-1-ium and cyclopamine) are disclosed to treat female infertility as the compounds increase the percentage of primary follicles relative to primordial follicles compared to control samples.

Abstract: This invention relates to compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use these compounds, for example in a method of treatment of cardiac conditions.

Abstract: This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).

Abstract: An electrical trainline junction box formed from a housing having first and second opposing sides, an identification module positioned in the housing, and first and second receptacles positioned in each of the first and second opposing sides. The first and second receptacles have a plurality of electrical contacts arranged in a predetermined geometry so that only one possible orientation and electrical connection to trainline flanges is possible. The flanges include contact pins in inserts coupled to the flanges by sleeves. The outer surface of the inserts and the inner surface of the sleeves are keyed to allow only a single orientation of the inserts relative to the sleeves. The outer surface of the sleeves is shaped to allow only a single orientation of the sleeves relative to the flanges, thus ensuring that the proper electrical connection is made when the junction box is installed.

Abstract: An electrical trainline junction box formed from a housing having first and second opposing sides, an identification module positioned in the housing, and first and second receptacles positioned in each of the first and second opposing sides. The first and second receptacles have a plurality of electrical contacts arranged in a predetermined geometry so that only one possible orientation and electrical connection to trainline flanges is possible. The flanges include contact pins in inserts coupled to the flanges by sleeves. The outer surface of the inserts and the inner surface of the sleeves are keyed to allow only a single orientation of the inserts relative to the sleeves. The outer surface of the sleeves is shaped to allow only a single orientation of the sleeves relative to the flanges, thus ensuring that the proper electrical connection is made when the junction box is installed.

Abstract: A trainline integrity locomotive test device is provided that is configured to provide conventionally provided End-Of-Train (EOT) functionality required for a single locomotive test as well as functionality necessary for troubleshooting electrical problems in trainline electrical conductors, wherein the trainline integrity locomotive test device includes a reduced number of components in comparison with a conventional EOT device. Additionally, the test device is provided in more compact, durable and robust form relative to conventional EOT devices. As part of the transmission of trainline integrity data from the test device to the Head-End-Unit, a communications heartbeat signal is substituted for brake pipe pressure conventionally detected by EOT devices, so as to provide an indication of data communication reliability.

Abstract: An operator interface unit, includes a housing with a first electrical port having a first pair of terminals to be connect to a pair of network wires of the locomotive, and a second pair of terminals to be connected to a power source. A display and input device are on the housing. A transceiver assembly wirelessly communications with the ECP system. A controller assembly is connected to the first electrical port, the display, the input device and the transceiver assembly, and wherein the controller assembly is a node on the network via one of the first electrical port and the transceiver assembly. A portable assembly includes a battery source in a container which irremovably houses the operator interface unit.

Abstract: An End of Car (EOC) junction box assembly includes a housing wherein a plurality of female/female contact sockets couple with a corresponding plurality of male contact pins and are positioned by a fitting that enables the female/female contact sockets to interface with an EOC receptacle plug also included in the housing body, such that alternate positions of the fitting and EOC receptacle plug are available during assembly while the components included in the housing body are restrained from rotation following assembly.

Abstract: An End of Car (EOC) junction box assembly includes a housing wherein a plurality of female/female contact sockets couple with a corresponding plurality of male contact pins and are positioned by a fitting that enables the female/female contact sockets to interface with an EOC receptacle plug also included in the housing body, such that alternate positions of the fitting and EOC receptacle plug are available during assembly while the components included in the housing body are restrained from rotation following assembly.

Abstract: A trainline integrity locomotive test device is provided that is configured to provide conventionally provided End-Of-Train (EOT) functionality required for a single locomotive test as well as functionality necessary for troubleshooting electrical problems in trainline electrical conductors, wherein the trainline integrity locomotive test device includes a reduced number of components in comparison with a conventional EOT device. Additionally, the test device is provided in more compact, durable and robust form relative to conventional EOT devices. As part of the transmission of trainline integrity data from the test device to the Head-End-Unit, a communications heartbeat signal is substituted for brake pipe pressure conventionally detected by EOT devices, so as to provide an indication of data communication reliability.

Abstract: The treatment of pain and related use by topical administration of an N-substituted-14-hydroxydihydronormorphine to a subject in need thereof. In some embodiments, the N-substituted-14-hydroxydihydronormorphine is nalbuphine.

Abstract: Fluorinated copolymers useful in photoresist compositions and associated processes for microlithography are described. These copolymers are comprised of a fluoroalcohol or protected fluoroalcohol functional group which simultaneously imparts high ultraviolet (UV) transparency and developability in basic media to these materials and a repeat unit derived from an acrylate monomer containing a fluoroalkyl group or a hydroxyl substituted alkyl group. The materials of this invention have high UV transparency, particularly at 193 and 157 nm, which makes them highly useful for lithography at these short wavelengths.

Abstract: A method of setting an electropneumatic brake device on a rail car to a mode of operation includes applying a wake-up voltage on a trainline to each brake device connected to the trainline. A command signal is sent to each brake device to enter a requested mode of operation. An acknowledgement signal is received from each of the brake devices on the trainline, and a command signal is sent to each brake device to stop broadcasting.

Abstract: A system for uniformly dispensing agricultural chemicals in soil comprises a holding reservoir for the liquid agrichemicals, at least one multi-port uniform dispersing manifold or splitter, and a number of dispensing delivery tubes for dispensing the chemicals proximate openings or slits in the soil during various functions such as planting. The liquid agricultural chemicals, within the system, flow, under pressure, from the reservoir to the exit orifice of each delivery conduit. The multi-port, uniform liquid dispersing manifold passively equally and uniformly, divides the incoming fluid stream to provide separate, but substantially equal, divided fluid streams exiting the manifold to individual delivery conduits.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.

Abstract: Fluorinated polymers, photoresists and associated processes for microlithography are described. These polymers and photoresists are comprised of esters derived from fluoroalcohol functional groups that simultaneously impart high ultraviolet (UV) transparency and developability in basic media to these materials. The materials of this invention have high UV transparency, particularly at short wavelengths, e.g., 157 nm, which makes them highly useful for lithography at these short wavelengths.

Abstract: Compounds represented by Formula (I): 1

Abstract: Fluorinated polymers, photoresists and associated processes for microlithography are described. These polymers and photoresists are comprised of esters derived from fluoroalcohol functional groups that simultaneously impart high ultraviolet (UV) transparency and developability in basic media to these materials. The materials of this invention have high UV transparency, particularly at short wavelengths, e.g., 157 nm, which makes them highly useful for lithography at these short wavelengths.

Abstract: It has been found that surface reactions with basic materials such as amines found in the processing environment during lithographic processing contribute to a loss of linewidth control for resists such as chemically amplified resists. This loss in linewidth results from the reaction of the acid generated by exposing radiation with, for example, the amine resulting in a lack of chemical reaction where such reaction is desired. The problem is solved in one embodiment by employing an acid containing barrier layer on the resist.