Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A system and method for Enable PIN Debit Transactions at Internet Based Online Merchants by Using a Combination of IVR and Hardware Security Module is provided. The system may include an adaptive payment server including one or more processors configured to receive a first communication including first identification information from a first communication device on a first communication channel. The adaptive payment server may identify a second communication device based on the first identification information and initiate a second communication to the second communication device on a second communication channel, which may be discrete from the first communication channel. The adaptive payment server may receive second identification information from the second communication device on the second communication channel and authenticate the payment transaction using the first identification information and the second identification information.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A seat cushion assembly for an aircraft includes a base member with a recess having an upwardly facing lower surface that includes a plurality of spaced apart, elongated continuous first ridges extending upward from the lower surface of the recess and laterally towards its opposite sidewalls. The plurality of first ridges are spaced apart from front to rear relative to the seat cushion assembly to define a plurality of first grooves that extend laterally towards the opposite sidewalls. A central cushion member is positioned within the recess and is configured in a complimentary manner to be received within the recess of the base member. The base member is formed of a resilient foam material that is more rigid than the foam material of which the central cushion member is formed. A laterally extending hole is located in one of the base member or the central cushion member.

Abstract: A system and method for secure payment transactions is provided. The system may include an adaptive payment server including one or more processors configured to receive a first communication including first identification information from a first communication device on a first communication channel. The adaptive payment server may identify a second communication device based on the first identification information and initiate a second communication to the second communication device on a second communication channel, which may be discrete from the first communication channel. The adaptive payment server may receive second identification information from the second communication device on the second communication channel and authenticate the payment transaction using the first identification information and the second identification information.

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act.

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act.

Abstract: Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A simplified method for production of a commercial supply liquefied natural gas (LNG) supplied in a pressurized vessel includes taking a supply of natural gas including contaminants from a stranded well or from a pipe line and extracting from the supply gas water vapor and CO2 in a fixed bed absorption system. In a first stage the supply gas is separated into first and second streams where the first stream contains all the cold energy available from the feed stream and sufficient of the contaminants are removed to meet a product specification for the composition of the LNG supply. In a second stage the first stream is liquefied by the available cool energy for commercial pressurized supply container The second stream contains natural gas which is as much as 75% of the feed stream together with substantially all the contaminants and is used as a natural gas supply.

Abstract: A handheld searchlight for producing a high intensity beam of light output has an elongated housing including a handle portion for gripping by a user. A head has a window opening for transmitting a light beam. There is a mechanical coupling between the housing and the head. A parabolic reflector is mounted in the head facing the window and has an aperture for accommodating a high intensity lamp. The reflector has a longitudinal optical axis. The rotation of the head about the coupling causes movement of the parabolic reflector relative to the lamp along the optical axis thereby changing a spread of the high-intensity light beam. The searchlight further includes a rotatable bezel ring mounted on the head and a filter ring mount connected to the rotatable bezel. An optical filter is mounted in the filter ring mount.

Abstract: A night vision system for use in a vehicle includes a night vision device configured as a handheld monocular device. A mount for coupling the night vision device to the vehicle includes a mounting plate configured for attachment at an attachment point in the interior of the vehicle, a coupling assembly coupled to the mounting plate and coupled to a quick release plate of a quick release mechanism, the coupling assembly configured to permit adjustment of orientation of a mounted night vision device in elevation and azimuth. The quick release mechanism is configured to allow one-handed removal of the night vision device from the mount. Image data captured by the night vision device may be communicated through a communications link to a display device in the vehicle.

Abstract: A system and method of processing balance inquiries and electronic funds transfers (EFTs) using multi-factor authentication. The method may include receiving an identifier of a financial account and contact information associated with the financial account and initiating a communication via the contact information. Upon receiving an authentication via the communication, the method may include processing a balance inquiry and/or EFT of the financial account based on the identifier and the authentication. The method may include determining a balance of the financial account based on the balance inquiry and/or causing funds to be electronically transferred. The system and method may also facilitate a balance inquiry from a mobile device to an EFT provider.

Abstract: A long range illumination system includes a handheld illumination device, includes a housing having an elongated body and a head coupled to one end. A switch disposed on an outer surface of the housing receives an input from a user. At least one power source supplies electrical power to the handheld illumination device. A lamp produces high intensity light for illumination. The lamp is disposed within a parabolic reflector having an aperture and movable about an optical axis of symmetry relative to the lamp for projecting a high intensity beam. A green optical filter moveably mounted to the head is substantially covers an end of the reflector in a first position, and does not cover the end of the reflector in a second position. A processor is configured to receive the input signal and causes an output power level to said lamp based on the input signal.

Abstract: A handheld searchlight for producing a high intensity beam of light output has an elongated housing including a handle portion for gripping by a user. A head has a window opening for transmitting a light beam. There is a mechanical coupling between the housing and the head. A parabolic reflector is mounted in the head facing the window and has an aperture for accommodating a high intensity lamp. The reflector has a longitudinal optical axis. The rotation of the head about the coupling causes movement of the parabolic reflector relative to the lamp along the optical axis thereby changing a spread of the high-intensity light beam. The searchlight further includes a rotatable bezel ring mounted on the head and a filter ring mount connected to the rotatable bezel. An optical filter is mounted in the filter ring mount.

Abstract: A handheld searchlight for producing a high intensity beam of light output has an elongated housing including a handle portion for gripping by a user. A head has a window opening for transmitting a light beam. There is a mechanical coupling between the housing and the head. A parabolic reflector is mounted in the head facing the window and has an aperture for accommodating a high intensity lamp. The reflector has a longitudinal optical axis. The rotation of the head about the coupling causes movement of the parabolic reflector relative to the lamp along the optical axis thereby changing a spread of the high-intensity light beam. The searchlight further includes a rotatable bezel ring mounted on the head and a filter ring mount connected to the rotatable bezel. An optical filter is mounted in the filter ring mount.

Abstract: A low-light viewing device includes a housing, having mounted thereto: a lens, an electronic camera for receiving light focused by the lens and for providing an output signal; a display for receiving the output signal and displaying an image detected by the camera; a controller for controlling the camera and the display, and a user interface for operating the controller. The lens may be a fixed focus lens having an F number of less than about 1, and a T number of less than about 1.5. The display may have a resolution at least as great as the resolution of the camera. The device may have a processor programmed to provide control signals to the camera and display depending on a selected light environment.

Abstract: A system and method for a recurring payment transaction is provided. A system of authenticating a recurring payment transaction may include an adaptive payment server that includes one or more processors configured to retrieve account information, which may include a payment date and an identification of a communication device of a payor. The adaptive payment server may initiate a communication to the communication device on or before the payment date and communicate at least a portion of the account information to the communication device. The adaptive payment server may receive, from the communication device, approval information and determine whether to initiate payment of the recurring payment transaction using the approval information. The adaptive payment server may initiate payment of the recurring payment transaction based on the determination.