Abstract: An inhalable dry powder medicament is provided. The medicament, which provides improved fine particle fraction, may be prepared by (i) fractionating a particulate active ingredient based on aerodynamic particle size, (ii) recovering at least one fraction of the particulate active ingredient and (iii) combining the recovered fraction with a carrier to provide the inhalable dry powder medicament.

Abstract: Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as cyclosporin A encapsulated in the liposomes. A method for preparing a pharmaceutical composition includes producing liposomes from phospholipids, preferably in the presence of a pharmaceutically active substance (most preferably cyclosporin A) to be encapsulated within the liposomes, and mixing the liposomes with hyaluronic acid. Pharmaceutical compositions of this invention are used, for example, to topically administer pharmaceutical agents effective to treat skin disorders by deposition of that agent in the dermis or sub-dermis while minimizing systemic circulation thereof. These compositions are also administered orally, parenterally and intrarectally.

Abstract: A process for the production of crystals with controlled surface smoothness, size, shape and degree of crystallinity, compositions comprising such crystals, and the use of certain crystals, especially lactose, lactose monohydrate, fluticasone propionate, salmeterol xinafoate, salbutamol sulphate or ipratropium bromide in pharmaceutical compositions.

Abstract: A dry particulate pharmaceutical composition for pulmonary administration is prepared by spray-drying a hydrophobic active agent (e.g. declomethasone dipropionate) with a small quantity of pharmaceutically acceptable hydrophilic polymer (e.g. poly (vinyl) alcohol). This mitigates aggregation of the particles of active agent, which otherwise limits the desirable find particles dose available.

Abstract: Elongated drug, especially salbutamol sulphate, and/or carrier particles, especially lactose, pharmaceutical compositions comprising the same, and use of the elongated particles in the manufacture of a medicament for the treatment of respiratory disease.

Abstract: Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as cyclosporin A encapsulated in the liposomes. A method for preparing a pharmaceutical composition includes producing liposomes from phospholipids, preferably in the presence of a pharmaceutically active substance (most preferably cyclosporin A) to be encapsulated within the liposomes, and mixing the liposomes with hyaluronic acid. Pharmaceutical compositions of this invention are used, for example, to topically administer pharmaceutical agents effective to treat skin disorders by deposition of that agent in the dermis or sub-dermis while minimizing systemic circulation thereof. These compositions are also administered orally, parenterally and intrarectally.

Abstract: A dry powder inhaler is provided which comprises a reservoir of medicament powder, a dispensing chamber for receiving a charge of powder to be dispensed having a floor upon which the powder charge lies prior to inhalation, an inlet passage having at its outlet end a nozzle protruding into the dispensing chamber directed toward the floor thereof and an inhalation passage exiting from the chamber through which the powder may be inhaled entrained in air drawn into the inhaler through the air inlet passage. The inhalation passage has an inlet at the dispensing chamber and an outlet through which the powder may be inhaled and comprises a first upstream portion having a roof and a floor both of which rise progressively with respect to a straight line drawn form the center of the inlet to the center of the outlet ad a second portion having a roof and a floor both of which fall progressively with respect to the line in the downstream direction.