Abstract: Disclosed herein are inhibitors of aminocarboxymuconate semialdehyde decarboxylase (ACMSD), pharmaceutical compositions and methods for using these compounds to treat or prevent one or more ACMSD-related diseases such as, for example, muscle structure disorders, neuronal activation disorders, muscle fatigue disorders, muscle mass disorders, beta oxidation diseases, metabolic diseases, cancer, vascular diseases, ocular vascular diseases, muscular eye diseases, liver diseases, inflammatory diseases or renal diseases.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: In one example, a method includes positioning a tool in a mold, forming a parison of melted plastic, closing the mold around the parison and tool such that part of the tool is positioned between a portion of the mold and the parison, creating a blow molded structure by inflating the parison so that the melted plastic comes into contact with an interior portion of the mold and into contact with the tool, and after the mold is closed, operating the tool to form an integral compression molded element within the mold, and a parting line formed by the mold in the blow molded structure forms no part of the integral compression molded element.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: In one example, a structure is provided that includes a plastic body having a unitary, single-piece construction. The plastic body further includes a substantially hollow interior, and a parting line that extends around a portion of the perimeter of the structure. The structure also includes a solid compression molded element that is integral with the plastic body. The solid compression molded element is configured and arranged such that the parting line is not connected to the solid compression molded element.

Abstract: The improved thinning or clearcut head is configured a tree harvesting vehicle supported by a plurality of wheels and tires. The improved thinning or clearcut head is adapted for use in cutting down a target tree. The improved thinning or clearcut head comprises a tree harvesting vehicle and a lateral pivot apparatus. The tree harvesting vehicle comprises a harvest vehicle and a cutting tool. The lateral pivot apparatus attaches the cutting tool to the harvest vehicle such that the cutting tool rotates around a lateral axis of rotation that is parallel to the center axis of the target tree. The improved thinning or clearcut head aligns the cutting tool with the target tree such that the alignment axis between the clamping arms of the cutting tool and the target tree is offset from primary sense of direction of the harvest vehicle.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, W, A?, B?, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

Abstract: In one example, a structure is provided that includes a plastic body having a unitary, single-piece construction. The plastic body further includes a substantially hollow interior, and a parting line that extends around a portion of the perimeter of the structure. The structure also includes a solid compression molded element that is integral with the plastic body. The solid compression molded element is configured and arranged such that the parting line is not connected to the solid compression molded element.

Abstract: In one example, a structure is provided that includes a plastic body having a unitary, single-piece construction. The plastic body further includes a substantially hollow interior, and a parting line that extends around a portion of the perimeter of the structure. The structure also includes a solid compression molded element that is integral with the plastic body. The solid compression molded element is configured and arranged such that the parting line is not connected to the solid compression molded element.

Abstract: In one example, a method includes positioning a tool in a mold, forming a parison of melted plastic, closing the mold around the parison and tool such that part of the tool is positioned between a portion of the mold and the parison, creating a blow molded structure by inflating the parison so that the melted plastic comes into contact with an interior portion of the mold and into contact with the tool, and after the mold is closed, operating the tool to form an integral compression molded element within the mold, and a parting line formed by the mold in the blow molded structure forms no part of the integral compression molded element.

Abstract: The improved thinning or clearcut head is configured a tree harvesting vehicle supported by a plurality of wheels and tires. The improved thinning or clearcut head is adapted for use in cutting down a target tree. The improved thinning or clearcut head comprises a tree harvesting vehicle and a lateral pivot apparatus. The tree harvesting vehicle comprises a harvest vehicle and a cutting tool. The lateral pivot apparatus attaches the cutting tool to the harvest vehicle such that the cutting tool rotates around a lateral axis of rotation that is parallel to the center axis of the target tree. The improved thinning or clearcut head aligns the cutting tool with the target tree such that the alignment axis between the clamping arms of the cutting tool and the target tree is offset from primary sense of direction of the harvest vehicle.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A foot assembly includes a block retainer and a non-skid block. The block retainer is configured to be positioned at least proximate to an edge between a bottom surface and a side surface of a structure. The block retainer includes a planar portion, an angled portion, and a front surface. The planar portion has an interior surface configured to contact the bottom surface. The angled portion is diposed at an angle from the planar portion and includes an interior surface configured to contact an angled contact surface of the structure. The front surface includes a first dynamic coefficient of friction (DCOF). The non-skid block is connected to the planar portion and includes an exterior portion extending from the front surface away from the structure and includes a second DCOF greater than the first DCOF.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R1, R2, R3, R4, and R6 are as described herein.

Abstract: A folding chair may include a frame that is configured to transition the folding chair between use and storage positions. A seat base may be pivotally coupled thereto at a first particular length from a front end and a receiving portion may be disposed in an upper surface. The receiving portion may include left and right lateral edges, front and rear longitudinal edges, and a depth. The padding material may be disposed in the receiving portion and may have a lateral dimension related to a distance between the front and the rear longitudinal edges, a longitudinal dimension related to a distance between the front and the rear longitudinal edges, and a thickness related to the depth. The padding layer may cover a majority of a top surface of the padding material and of the upper surface. The cover may retain the padding material and the padding layer relative to the seat base.

Abstract: A foot assembly includes a block retainer and a non-skid block. The block retainer is configured to be positioned at least proximate to an edge between a bottom surface and a side surface of a structure. The block retainer includes a planar portion, an angled portion, and a front surface. The planar portion has an interior surface configured to contact the bottom surface. The angled portion is diposed at an angle from the planar portion and includes an interior surface configured to contact an angled contact surface of the structure. The front surface includes a first dynamic coefficient of friction (DCOF). The non-skid block is connected to the planar portion and includes an exterior potion extending from the front surface away from the structure and includes a second DCOF greater than the first DCOF.