Patents by Inventor Gary Piazza

Gary Piazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of sulindac can protect normal cells against oxidative damage
    Patent number: 11834404
    Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: December 5, 2023
    Assignee: University of South Alabama
    Inventors: Gary Piazza, Xi Chen, Herbert Weissbach, Shailaja Kesraju Allani
  • DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE
    Publication number: 20220106250
    Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.
    Type: Application
    Filed: November 15, 2021
    Publication date: April 7, 2022
    Applicant: UNIVERSITY OF SOUTH ALABAMA
    Inventors: Gary Piazza, Xi Chen, Herbert Weissbach, Shailaja Kesraju Allani
  • Derivatives of sulindac can protect normal cells against oxidative damage
    Patent number: 11186534
    Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: November 30, 2021
    Assignee: UNIVERSITY OF SOUTH ALABAMA
    Inventors: Gary Piazza, Xi Chen, Herbert Weissbach, Shailaja Kesraju Allani
  • DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE
    Publication number: 20200095184
    Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.
    Type: Application
    Filed: March 16, 2018
    Publication date: March 26, 2020
    Applicant: University of South Alabama
    Inventors: Gary Piazza, Xi Chen, Herbert Weissbach, Shailaja Kesraju Allani
  • Derivatives of sulindac, use thereof and preparation thereof
    Patent number: 8044048
    Abstract: Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: October 25, 2011
    Assignee: Southern Research Institute
    Inventors: Gary Piazza, Robert Reynolds
  • 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF
    Publication number: 20110178106
    Abstract: 5-Quinolinone and Imidazopyrimidine compounds are provided that are useful for inhibiting the efflux of any therapeutic agent that is a MRP1 substrate. Also provided is a method for screening to identify additional MRP1 inhibitors.
    Type: Application
    Filed: July 10, 2009
    Publication date: July 21, 2011
    Applicant: SOUTHERN RESEARCH INSTITUTE OFFICE OF COMMERCIALIZ
    Inventors: Joseph A. Maddry, Adam Keeton, Jason Whitt, Gary Piazza
  • Derivatives of sulindac, use thereof and preparation thereof
    Publication number: 20070244122
    Abstract: Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.
    Type: Application
    Filed: January 4, 2007
    Publication date: October 18, 2007
    Applicant: Southern Research Institute Office of Commercialization and Intellectual Property
    Inventors: Gary Piazza, Robert Reynolds
  • Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds
    Publication number: 20050244914
    Abstract: This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Application
    Filed: July 7, 2005
    Publication date: November 3, 2005
    Inventors: Li Liu, Bing Zhu, Han Li, W. Thompson, Rifat Pamukcu, Gary Piazza
  • Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
    Patent number: 6479520
    Abstract: Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: November 12, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Gary Piazza, Rifat Pamukcu
  • Method of inhibiting neoplastic cells with 4,5-diaminopyrimidine derivatives
    Patent number: 6380206
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to 4,5-diaminopyrimidine derivatives.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: April 30, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B] indole derivatives
    Publication number: 20020035111
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to pyrido[3,4b]indoles.
    Type: Application
    Filed: October 10, 2001
    Publication date: March 21, 2002
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives
    Publication number: 20020025968
    Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to 4-aminoquinazoline derivatives.
    Type: Application
    Filed: September 14, 2001
    Publication date: February 28, 2002
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method of treating a patient having precancerous lesions with quinazoline derivatives
    Publication number: 20010031760
    Abstract: Derivatives of Quinazoline are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Application
    Filed: May 7, 2001
    Publication date: October 18, 2001
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method for treating patients with macular degeneration by administering substituted sulfonyl indenyl acetic acids and alcohols
    Publication number: 20010020020
    Abstract: Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of macular degeneration.
    Type: Application
    Filed: April 9, 2001
    Publication date: September 6, 2001
    Inventors: Rifat Pamukcu, Gary Piazza, Ewa Skopinska-Rozewska
  • Method of treating a patient having precancerous lesions with quinazoline derivatives
    Patent number: 6262059
    Abstract: Derivatives of Quinazoline are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: July 17, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method for treating patients with diabetic retinopathy by administering substituted sulfonyl indenyl acetic acids and alcohols
    Publication number: 20010006965
    Abstract: Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of diabetic retinopathy.
    Type: Application
    Filed: February 8, 2001
    Publication date: July 5, 2001
    Inventors: Rifat Pamukcu, Gary Piazza, Ewa Skopinska-Rozewska
  • Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
    Patent number: 6239136
    Abstract: Derivatives of Phenyl Pyrimidinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 29, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method for treating a patient having precancerous lesion with 4-phenylphthalazine derivatives
    Patent number: 6207666
    Abstract: Derivatives of 4-phenylphthalazine are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: March 27, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Gary Piazza, Rifat Pamukcu
  • Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
    Patent number: 6046216
    Abstract: Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: April 4, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Gary Piazza, Rifat Pamukcu
  • Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
    Patent number: 6046206
    Abstract: Derivatives of quinazoline are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: April 4, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary Piazza