Patents by Inventor Gary R. Gustafson
Gary R. Gustafson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180183380Abstract: The present invention is an apparatus and method using solar insolation to heat fluid moving through panels, resulting in relatively hot fluid. A set of such panels might be installed in a window. Heat is removed from the hot fluid in a heat reservoir or heat sink, resulting in relatively cool fluid. In some embodiments, the hot fluid and the cool fluid are placed in thermal contact with opposite sides of a thermoelectric generator, thereby generating electricity. In some embodiments, photovoltaic cell modules are embedded in the panels, the fluid system improving the effectiveness of the cells. A given system might use either approach to generate electricity, or both. Heat from the heat reservoir might be used to heat a building. A thermoelectric system might be run in reverse at night.Type: ApplicationFiled: June 9, 2016Publication date: June 28, 2018Inventor: Gary R. Gustafson
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Publication number: 20170174658Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.Type: ApplicationFiled: March 7, 2017Publication date: June 22, 2017Inventors: Jian LIN, Anna ERICSSON, Ann-Marie CAMPBELL, Gary R. GUSTAFSON, Zhongguo WANG, R. Bruce DIEBOLD, Susan ASHWELL, David LANCIA, JR., Justin Andrew CARAVELLA, Wei LU
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Patent number: 8835422Abstract: The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.Type: GrantFiled: December 1, 2009Date of Patent: September 16, 2014Assignee: Cara Therapeutics, Inc.Inventors: Stephen J. O'Connor, Jason S. Newcom, Janet L. Ralbovsky, Gary R. Gustafson, R. Paul Beckett, Robert Zhiyong Luo
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Patent number: 8650877Abstract: The present invention is a solar panel that generates electricity and extracts heat. A set of such panels may be assembled into a blind. The blind may have a frame that can be retrofit on an existing window. Fluid in the panel is heated by incoming solar radiation, causing it to move, constrained by a one-way valve, in one direction. A Tesla Valve may be used as the one-way valve. The moving fluid may pass through a generator, generating electricity. Heat may be extracted from the fluid by a heat exchanger. The heat may be used to heat a building.Type: GrantFiled: March 11, 2013Date of Patent: February 18, 2014Inventor: Gary R. Gustafson
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Patent number: 8431565Abstract: The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.Type: GrantFiled: December 18, 2008Date of Patent: April 30, 2013Assignee: Cara Therapeutics, Inc.Inventors: R. Paul Beckett, Richard Foster, Christelle Henault, Janet L. Ralbovsky, Carla M. Gauss, Gary R. Gustafson, Robert Zhiyong Luo, Ann-Marie Campbell, Tatiana E. Shelekhin, Mary-Margaret E. Zablocki
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Publication number: 20120015930Abstract: The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.Type: ApplicationFiled: December 1, 2009Publication date: January 19, 2012Applicant: CARA THERAPEUTICS, INC.Inventors: Stephen J. O'Connor, Jason S. Newcom, Janet L. Ralbovsky, Gary R. Gustafson, R. Paul Beckett, Robert Zhiyong Luo
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Patent number: 7960377Abstract: The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R1, R2, R3 and R4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.Type: GrantFiled: March 24, 2009Date of Patent: June 14, 2011Assignee: Cara Therapeutics, Inc.Inventors: Jason S. Newcom, Stephen J. O'Connor, Gary R. Gustafson
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Patent number: 7960376Abstract: The present invention provides benzo-fused heterocyclic compounds having the structure of formula I, as well as prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof. The compounds directly or indirectly modulate the activity of one or more cannabinoid receptors and can be incorporated into pharmaceutical preparations that are useful for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.Type: GrantFiled: September 10, 2008Date of Patent: June 14, 2011Assignee: Cara Therapeutics, Inc.Inventors: Jason S. Newcom, Carla M. Gauss, Gary R. Gustafson
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Publication number: 20090247502Abstract: The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R1, R2, R3 and R4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.Type: ApplicationFiled: March 24, 2009Publication date: October 1, 2009Applicant: CARA THERAPEUTICS, INC.Inventors: Jason S. Newcom, Stephen J. O'Connor, Gary R. Gustafson
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Publication number: 20090149450Abstract: The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.Type: ApplicationFiled: December 18, 2008Publication date: June 11, 2009Applicant: CARA THERAPEUTICS, INC.Inventors: R. Paul Beckett, Richard Foster, Christelle Henault, Janet L. Ralbovsky, Carla M. Gauss, Gary R. Gustafson, Robert Zhiyong Luo, Ann-Marie Campbell, Tatiana E. Shelekhin, Mary-Margaret E. Zablocki
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Publication number: 20090075973Abstract: The present invention provides benzo-fused heterocyclic compounds having the structure of formula I, as well as prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof. The compounds directly or indirectly modulate the activity of one or more cannabinoid receptors and can be incorporated into pharmaceutical preparations that are useful for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.Type: ApplicationFiled: September 10, 2008Publication date: March 19, 2009Applicant: CARA THERAPEUTICS, INC.Inventors: Jason S. Newcom, Carla M. Gauss, Gary R. Gustafson
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Publication number: 20080318935Abstract: The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.Type: ApplicationFiled: June 20, 2008Publication date: December 25, 2008Applicant: CARA THERAPEUTICS, INC.Inventors: R. Paul Beckett, Richard Foster, Christelle Henault, Janet L. Ralbovsky, Carla M. Gauss, Gary R. Gustafson, Zhiyong Luo, Ann-Marie Campbell, Tatiana E. Shelekhin
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Publication number: 20080161340Abstract: Tetrahydroquinolinone and tetrahydronaphthyridone cannabinoid receptor ligand compounds and stereoisomers, mixtures of stereoisomers, prodrugs, pharmaceutically acceptable salts, hydrates, solvates, acid salt hydrates, and isomorphic crystalline forms thereof are described.Type: ApplicationFiled: December 19, 2007Publication date: July 3, 2008Applicant: CARA THERAPEUTICS, INC.Inventors: Gary R. Gustafson, R. Paul Beckett
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Patent number: 7307079Abstract: The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-A3 receptors, as well as to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient. The invention relates to compounds of the general formula (1) wherein Y represents a group of the general formula (A), (B) or (C) and all other symbols have the meanings as given in the description.Type: GrantFiled: May 30, 2003Date of Patent: December 11, 2007Assignees: Solvay Pharmaceuticals, B.V., Arqule, Inc.Inventors: Jacobus A.J. Den Hartog, Jan H. Reinders, Guustaaf J.M. Van Scharrenburg, Maria L. Pras-Raves, Gary R. Gustafson
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Publication number: 20040038972Abstract: The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-A3 receptors, as well as to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient.Type: ApplicationFiled: May 30, 2003Publication date: February 26, 2004Inventors: Jacobus A.J. Den Hartog, Jan H. Reinders, Guustaaf J.M. Van Scharrenburg, Maria L. Pras-Raves, Gary R. Gustafson
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Publication number: 20020052295Abstract: Novel herbicidal compounds are provided having the formula (I) 1Type: ApplicationFiled: December 5, 2000Publication date: May 2, 2002Inventors: Shridhar G. Hegde, Daniel M. Krupa, Joseph A. Bohn, David L. Coffen, Gary R. Gustafson, Alan P. Kaplan, Yuting Ma
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Patent number: 6239291Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: May 18, 2000Date of Patent: May 29, 2001Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston UniversityInventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6228882Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: September 15, 1999Date of Patent: May 8, 2001Assignees: Anadys Pharmaceuticals, Inc., Scriptgen Pharmaceuticals, Inc.Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6184393Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: September 15, 1999Date of Patent: February 6, 2001Assignees: Trustees of Boston University, Scriptgen Pharmaceuticals, Inc.Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6140361Abstract: 2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.Type: GrantFiled: March 22, 1999Date of Patent: October 31, 2000Assignee: Scriptgen Pharmaceuticals, Inc.Inventors: Gary R. Gustafson, David G. Powers, Mark A. Wuonola