Patents by Inventor Gary R. Klimpel

Gary R. Klimpel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for vaccination against or involving enterobacteriaceae bacteria
    Patent number: 7655241
    Abstract: The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteriaceae with a non-functional lipoprotein for use as a vaccine or as a vaccine vector for delivering antigens to a subject to be vaccinated. In certain embodiments, a bacterium of the Enterobacteriaceae family lacking a wild type LP, for example Salmonella typhimurium lacking a wild type LP, may be produced and used as a vaccine or vaccine vector.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: February 2, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Gary R. Klimpel, David W. Niesel, Ashok Chopra, Jian Sha
  • Methods and compositions for vaccination against or involving enterobacteriaceae bacteria
    Publication number: 20030215464
    Abstract: The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteriaceae with a non-functional lipoprotein for use as a vaccine or as a vaccine vector for delivering antigens to a subject to be vaccinated. In certain embodiments, a bacterium of the Enterobacteriaceae family lacking a wild type LP, for example Salmonella typhimurium lacking a wild type LP, may be produced and used as a vaccine or vaccine vector.
    Type: Application
    Filed: March 20, 2003
    Publication date: November 20, 2003
    Inventors: Gary R. Klimpel, David W. Niesel, Ashok Chopra, Jian Sha
  • Method of using cytokine receptors on microorganism
    Patent number: 5374423
    Abstract: Cytokine receptors for tumor necrosis factor e which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries are provided.
    Type: Grant
    Filed: August 27, 1993
    Date of Patent: December 20, 1994
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gary R. Klimpel, David W. Niesel
  • Tumor necrosis factor receptors on microorganisms
    Patent number: 5270038
    Abstract: Cytokine receptors for tumor necrosis factor .alpha. which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries including vaccines with increased efficacy are provided.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: December 14, 1993
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gary R. Klimpel, David W. Niesel