Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A sliding door panel and assembly is described, such that when in the door panel is in an open arrangement there is a functional cooperation or coupling between at least a first unit and a second unit of the assembly. The second unit is generally affixed to the sliding door and the first unit is fixedly mounted with a sliding door guide system or to a header/footer or frame. A third unit may be included with the assembly such that when the sliding door panel is positioned in the open arrangement, the third unit limits engagement between the first and second units. In addition, the third unit is positioned to limit linear movement of a slideable portion of the first unit thereby preventing damage.

Abstract: Disclosed is a self-closing sliding door assembly operable to allow manual opening and controlled automatic closing of a sliding door. The door assembly comprises storage spools for storing biasing members biased in a wound position around the storage spools. The door assembly further comprises a main spool for winding a cable and the biasing members. When the door is moved towards an open position, the cable is unwound from the main spool, causing the spool to rotate in a first direction. When the main spool is rotated in the first direction, the biasing members are wound onto the main spool and store energy operable to generate a force to cause the main spool to rotate in a second direction. When the door is released, the energy stored in the biasing members rotates the main spool in the second direction, thereby winding the door cable and providing a sufficient force to move the door towards the closed position.

Abstract: Disclosed is a self-closing sliding door assembly operable to allow manual opening and controlled automatic closing of a sliding door. The door assembly comprises storage spools for storing biasing members biased in a wound position around the storage spools. The door assembly further comprises a main spool for winding a cable and the biasing members. When the door is moved towards an open position, the cable is unwound from the main spool, causing the spool to rotate in a first direction. When the main spool is rotated in the first direction, the biasing members are wound onto the main spool and store energy operable to generate a force to cause the main spool to rotate in a second direction. When the door is released, the energy stored in the biasing members rotates the main spool in the second direction, thereby winding the door cable and providing a sufficient force to move the door towards the closed position.

Abstract: A sliding door panel and assembly is described, such that when in the door panel is in an open arrangement there is a functional cooperation or coupling between at least a first unit and a second unit of the assembly. The second unit is generally affixed to the sliding door and the first unit is fixedly mounted with a sliding door guide system or to a header/footer or frame. A third unit may be included with the assembly such that when the sliding door panel is positioned in the open arrangement, the third unit limits engagement between the first and second units. In addition, the third unit is positioned to limit linear movement of a slideable portion of the first unit thereby preventing damage.

Abstract: A route and site-specific critical data system for emergency responders as they travel and approach an incident site, comprising a field survey database, a computer-executable GIS extension application interfaced with said database, a mobile GPS receiver, and a mobile user interface that includes a display screen capable of touch-screen icon selection including through gloved hands. The user interface mounted within one or more response vehicles displays multiple screen images, map-based, and photograph-based information, detailed text narratives and data in real-time along the entire route to an incident site, including past the public/private road intersection.

Abstract: A designer of a CAD model is automatically notified when parameter limits or tolerances are violated during the iterative design process. The efficiency in the design of a complex model is much improved from the automatic notification, because it enables the user to detect violations of parameter limits and tolerances as soon as they occur.

Abstract: A method, apparatus, and article of manufacture provide for drawing a graphical element in a computer-implemented drawing program. An existing instance of a graphical element pattern that defines a graphical distribution of multiple occurrences of a source graphical element is identified in a computer-implemented drawing program. A second graphical element is then associated with the existing instance of the graphical element pattern. In response to the associating, multiple occurrences of the second graphical element are positioned in accordance with the graphical element pattern.

Abstract: One or more embodiments of the invention provide a method, apparatus, and article of manufacture for positioning a graphical component in a computer-implemented drawing program. A selection of a graphical component displayed on a display device is received. Thereafter, a first feature of the graphical component is inferred. The display of the graphical component is moved (e.g., by a user using a cursor control device). Underlying geometry is then analyzed to determine one or more second features of the underlying geometry that can mate with the first feature. Feedback is then displayed that indicates placement potential for the graphical component based on the first feature mating with one of the second features.

Abstract: One or more embodiments of the invention provide a method, apparatus, and article of manufacture for defining mating properties of a graphical component in a computer-implemented drawing program. An option to create a first constraint interface for a first geometric characteristic of a first component is initiated. In response to the initiation, a dialog window for specifying settings for the first constraint interface regardless of whether a second constraint interface is currently displayed is displayed. The settings define mating properties for how the first geometric characteristic of the first component mates with the second constraint interface. Once specified, the first constraint interface of the first geometric characteristic is persisted with the first component.

Abstract: One or more embodiments of the invention provide a method, apparatus, and article of manufacture for positioning a graphical component in a computer-implemented drawing program. A selection of a graphical component displayed on a display device is received. Thereafter, a first feature of the graphical component is inferred. The display of the graphical component is moved (e.g., by a user using a cursor control device). Underlying geometry is then analyzed to determine one or more second features of the underlying geometry that can mate with the first feature. Feedback is then displayed that indicates placement potential for the graphical component based on the first feature mating with one of the second features.

Abstract: One or more embodiments of the invention provide a method, apparatus, and article of manufacture for defining mating properties of a graphical component in a computer-implemented drawing program. An option to create a first constraint interface for a first geometric characteristic of a first component is initiated. In response to the initiation, a dialog window for specifying settings for the first constraint interface regardless of whether a second constraint interface is currently displayed is displayed. The settings define mating properties for how the first geometric characteristic of the first component mates with the second constraint interface. Once specified, the first constraint interface of the first geometric characteristic is persisted with the first component.

Abstract: A method, apparatus, and article of manufacture provide for drawing a graphical element in a computer-implemented drawing program. An existing instance of a graphical element pattern that defines a graphical distribution of multiple occurrences of a source graphical element is identified in a computer-implemented drawing program. A second graphical element is then associated with the existing instance of the graphical element pattern. In response to the associating, multiple occurrences of the second graphical element are positioned in accordance with the graphical element pattern.

Abstract: A mining cable coupler has a hollow, cylindrical body. There is an entrance fitting for an electrical cable at a first end of the body. A plate-like insulator mount extends over the body near the second end and has insulator receiving apertures with annular recesses extending thereabout and inwardly from the second end of the body. There is a plurality of separate, tubular insulators. Each insulator has an annular outer projection extending thereabout and received within one of the recesses of the insulator mount. There is an annular seal fitted between each recess and the insulator therein. There is an elongated electrical contact within each insulator. A metal member has a tube extending about each insulator. An inner portion of the member is against the insulator mount. The inner portion has an aperture for each insulator smaller than the annular outer projection thereof and closely fitted about each insulator adjacent the projection. Fasteners releasably secure the metal member to the insulator mount.

Abstract: An offset lithographic press, as commonly found in the newspaper industry, is provided with an airless, pulsed spray dampening system for simplified, automatic control of the ink/dampening fluid balance. The dampening system is constructed in accordance with several critical parameters, including the center-to-center nozzle spacings, nozzle to adjacent roller spacings, as well as the frequency of pulses per minute, the duration of each pulse, and the pressure of the dampening fluid. Construction of a dampening system in accordance with the critical parameters enables the press to be operated with a minimum of user intervention, and the relatively small spacing between the nozzles and the adjacent rollers is such that the dampening system can be mounted adjacent the aisles between the press units for facilitating maintenance thereon.

Abstract: A printing press, especially of the offset newspaper printing type, includes an anti-wrinkle roller to function in cooperation with a web of paper being printed by the press. The roller has a pair of sections which are each independently adjustable eccentrically with respect to a common central axis. The roller is mounted transverse to the web. The eccentrically adjustable sections of the roller are manipulative to compensate for uneven tension across the width of the web so as to provide uniform tension and thereby reduce wrinkles produced by uneven tension in the web. Manual adjustment knobs or remotely controlled motors may be alternatively utilized to selectively adjust the eccentricity of the roller sections relative to one another and to the central axis thereof.

Abstract: A portable assembly for supporting cheese hoops in an inclined position from the vertical and including means for pressing the hoops so as to press the whey therefrom and permit it to drain downwardly from one hoop to the other to be collected therebelow. The frame includes support members for removably but firmly holding the hoops as they are being pressed by cylinder and piston units located at the top of the assembly. Control means are provided for actuating the units in extending or contracting directions. The gases actuating the cylinder and piston units are discharged to the floor of the apparatus, preventing their contaminating the hoops or curds that would be possible by release above those hoops.

Abstract: Web letterpress equipment is converted to offset lithographic equipment by modification of a driven letterpress impression cylinder to receive an offset blanket, thereby producing an offset blanket cylinder. A letterpress plate cylinder is modified to become an offset plate cylinder with accompanying offset inking and dampening equipment. In one embodiment, a driven letterpress plate cylinder of a color hump is packed to become an offset impression cylinder cooperating with the offset blanket cylinder. In a second embodiment, the letterpress plate cylinder of the color hump is modified to an offset color plate cylinder and a driven offset impression cylinder is added to cooperate with the offset printed on one side of a web. When used in combination with similarly converted letterpress plate, impression and color hump plate cylinders, at least three colors may be offset printed on one side of a web or multiple colors printed on opposite sides thereof.

Abstract: Web letterpress equipment is converted to offset lithographic equipment by modification of a driven letterpress impression cylinder to receive an offset blanket, thereby producing an offset blanket cylinder. A letterpress plate cylinder is modified to become an offset plate cylinder with accompanying offset inking and dampening equipment. In one embodiment a drive letterpress plate cylinder of a color hump is packed to become an offset impression cylinder cooperating with the offset blanket cylinder. In a second embodiment the letterpress plate cylinder of the color hump is modified to an offset color plate cylinder and a driven offset impression cylinder is added to cooperate with the offset blanket cylinder. In this manner at least two colors may be offset printed on one side of a web.