Abstract: The present invention relates to a microparticle. The microparticle includes one or more recombinant outer membrane vesicles, at least some of which display a fusion protein, where the fusion protein comprises at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides, and a polymeric coating over the one or more recombinant outer membrane vesicles. The present invention further relates to a method of eliciting an immune response in a mammal and a method of making encapsulated outer membrane vesicles displaying a fusion protein.

Abstract: Provided is a method for treatment and/or prophylaxis of FIP (feline infectious peritonitis) in cats. The method is performed by administering to a cat a composition comprising a therapeutic and/or prophylactic amount of a cysteine protease inhibitor. The cysteine protease inhibitor can be a selective cathepsin B inhibitor. Also provided is a method for inhibiting FIPV (Feline infectious peritonitis virus) replication. The method comprises contacting a cell infected with FIPV with a cysteine protease inhibitor in an amount effective to inhibit replication of FIPV. It is expected the method will be effective for therapy or prophylaxis of FIP in any species of cat and will be effective against any strain of feline coronavirus.

Abstract: Provided is a method for treatment and/or prophylaxis of FIP in cats. The method is performed by administering to a cat a composition comprising a therapeutic and/or prophylactic amount of a cysteine protease inhibitor. The cysteine protease inhibitor can be a selective cathepsin B inhibitor. Also provided is a method for inhibiting FIPV replication. The method comprises contacting a cell infected with FIPV with a cysteine protease inhibitor in an amount effective to inhibit replication of FIPV. It is expected the method will be effective for therapy or prophylaxis of FIP in any species of cat and will be effective against any strain of feline coronavirus.