Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: An example system includes a vehicle having a prime mover motively coupled to a drive line; a motor/generator selectively coupled to the drive line, and configured to selectively modulate power transfer between an electrical load and the drive line; a battery pack; a DC/DC converter electrically interposed between the motor/generator and the electrical load, and between the battery pack and the electrical load, the DC/DC converter comprising a DC/DC converter housing; and a covering tray positioned over a plurality of batteries of the battery pack, the covering tray comprising a connectivity layer configured to provide electrical connectivity to terminals of the plurality of batteries.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A pipe support may include a body. The body may include a first side. The first side may include a channel defined along a length of the body. The body may further include a second side opposite the first side. The second side may include a first planar surface. The body may further include a third side. The third side may include a concave surface defined along the length of the body. The body may further include a fourth side opposite the third side. The fourth side may include a second planar surface.

Abstract: The glass-based THz optical waveguides (10) disclosed herein are used to guide optical signals having a THz frequency in the range from 0.1 THz to (10) THz and include a core (20) surrounded by a cladding (30). The core has a diameter D1 in the range from (30) ?m to 10 mm and is made of fused silica glass having a refractive index n1. The cladding is made of either a polymer or a glass or glass soot and has a refractive index n2<n1 and an outer diameter D2 in the range from 100 ?m to 12 mm. The THz optical waveguides can be formed using processes that are extensions of either fiber, ceramic and soot-based technologies. In an example, the THz waveguides have a dielectric loss Df<0.005 at 100 GHz.

Abstract: The efficiency of roasting black dross can be improved by pre-processing the black dross before roasting. Black dross can be crushed and reconstituted into pellets having internal channels. The internal channels can be filled with additives designed to fully oxidize during a dross roasting process, enabling the internal channels to be open and gas to flow therethrough during a dross roasting process. The crushed black dross can be crushed to pieces below 10 mm and screened for larger pieces prior to pelletizing to ensure consistent pellets. Optionally, an eddy current separator can remove some metallic aluminum from the crushed black dross prior to pelletizing.

Abstract: Salt components of dross can be extracted efficiently through evaporation. During dross treatment, temperatures can be permitted to approach or exceed the boiling point of one or more salt components of the dross, preferably in an oxidizing environment. The temperature can be held sufficiently high such that the salt content can exert an appreciable vapor pressure and can be held for a sufficient time to permit most, all, or substantially all of the salt content to evaporate and be carried away from the kiln in combustion gasses. The evaporated salt can be condensed and collected.

Abstract: A two stage dross treatment capable of being performed in a single reaction vessel is disclosed. Dross, especially white dross, can be contacted with salt flux in a rotary furnace to recover metal from the dross. This first stage can recover metal during the conversion of white dross and salt flux to salt cake. In a second stage, the furnace can be raised to a sufficiently high temperature to evaporate the salt content of the salt cake, allowing the evaporated salt to exit the furnace and be separately condensed and collected. The result of the second stage is collected salt and salt-free oxides. After removing the salt-free oxides, residual heat in the furnace and collected salt can be used for a subsequent dross treatment.

Abstract: A technique for controlling access to one or more attractions is achieved using a number of access keys, each being issued to one or more users. An electronic queue management part manages a virtual queue in respect of each attraction and receives electronic requests for attraction access, each request relating to an access key and being for the users associated with it to access a particular attraction. Receipt of each request causes the respective users to be added to a corresponding virtual queue. A time at which each group of users reaches the front of the virtual queue and can access the attraction is determined. The users access the attractions by presenting an access key to an access control part, in communication with the electronic queue management part. Only a user presenting an access key at the correct time for accessing the attraction is allowed access to the attraction.

Abstract: Chemical compounds that are useful as inhibitors of mechanotransduction in the treatment of pain and modulation of touch perception and topical administration of the compounds described herein in the treatment of pain and modulation of touch perception.

Abstract: A system and method on a computer of more efficient, directional reversing reading format that may have directional guides is shown. The reader's eyes can smoothly and efficiently drop down to the next line, and then read content, as the eyes reverse naturally to the beginning direction. There also may be directional prompts to aid in the smooth flow of reading each line.

Abstract: An aircraft with an integrated boundary layer ingesting propulsion having a mechanically-distributed propulsion system. The mechanically-distributed propulsion system may include an engine to generate a mechanical drive power, a drive shaft, a direction-reversing transmission, and a propulsor fan. The drive shaft may be operatively coupled to the engine to receive the mechanical drive power. The direction-reversing transmission may have a first rotating shaft and a second rotating shaft, the first rotating shaft operatively coupled to the drive shaft to receive the mechanical drive power, which is configured to redirect the mechanical drive power received at the first rotating shaft from a first direction to face a second direction at the second rotating shaft. The propulsor fan may be coupled to the second rotating shaft to convert the mechanical drive power into thrust.

Abstract: An aircraft with an integrated boundary layer ingesting propulsion having a mechanically-distributed propulsion system. The mechanically-distributed propulsion system may include an engine to generate a mechanical drive power, a drive shaft, a direction-reversing transmission, and a propulsor fan. The drive shaft may be operatively coupled to the engine to receive the mechanical drive power. The direction-reversing transmission may have a first rotating shaft and a second rotating shaft, the first rotating shaft operatively coupled to the drive shaft to receive the mechanical drive power, which is configured to redirect the mechanical drive power received at the first rotating shaft from a first direction to face a second direction at the second rotating shaft. The propulsor fan may be coupled to the second rotating shaft to convert the mechanical drive power into thrust.

Abstract: There is provided a undercutting boring tool (10) comprising a bar body (11). A lost motion link consists of a spring (26) selectively compressed by a lost motion rod (27) having a lost motion slot (33) spaced from a drive pin (34). An operating rod portion (36) has a trunnion body (37) at its front end having a pin (41) adapted to engage the lost motion slot (33). A tool carrier (42) forms a pair of spaced flat tines (43) and forms a bearing surface (44) in the bight. The upper tine (43) and the bearing surface (44) section are slotted at (45) to allow the passage of a control link (46). Apertures (47) in the tines (43) engage pins (50) on the trunnion body (37). The bar of a generally H-shaped tool assembly (52) comprises a bearing surface (53) running in the bearing surface (44). A crank portion (54) is connected to the control link (46) via crank pin (55).

Abstract: A strut insulator for an overhead rail contact system includes a first end fitting, the first end fitting defining an inner side pocket, and a second end fitting spaced from the first end fitting, the second end fitting defining an inner side pocket. The strut insulator further includes a rod extending between the first end fitting and the second end fitting and extending into the inner side pockets of the first and second end fittings, the rod defining a length. The strut insulator further includes a shell surrounding a portion of rod, the shell extending along a portion of the length of the rod, the shell formed from a fluoropolymer.

Abstract: The present invention is a guitar pick with a slot or channel for attaching the pick to guitars, guitar straps, clothing buttons, beads, and other accommodations and also the slot being able to control the orientation and retention of the instrument pick. The slot allows for attachments to be made to the picks, for enhanced gripping, for tonal changes, for offsetting finger dulling effects, and for stacking/adjoining for a variety of effects.

Abstract: The present invention is a guitar pick with a slot or channel for attaching the pick to guitars, guitar straps, clothing buttons, beads, and other accommodations and also the slot being able to control the orientation and retention of the instrument pick. The slot allows for attachments to be made to the picks, for enhanced gripping, for tonal changes, for offsetting finger dulling effects, and for stacking/adjoining for a variety of effects.

Abstract: Aquatic curtain devices and methods for forming waterway channels and reducing waterway maintenance are disclosed. Each curtain device comprises an elongated float and an elongated flexible curtain depending from a first side of the elongated float. The curtain has a bottom end with a weight extending along the entire length of the elongated float. The float is configured to be sufficiently buoyant to support the curtain in an upward direction. Each curtain device is configured for the curtain to remain in a substantially taut state when in use and accommodate fluctuations in water levels, such that the elongated weight remains on the bottom of the waterway while the elongated float remains on the surface. Artificial channels are constructed by selecting the length of the elongated float to achieve the desired channel dimensions using two or more curtain devices positioned along a desired path in a waterway.

Abstract: There is provided a undercutting boring tool (10) comprising a bar body (11). A lost motion link consists of a spring (26) selectively compressed by a lost motion rod (27) having a lost motion slot (33) spaced from a drive pin (34). An operating rod portion (36) has a trunnion body (37) at its front end having a pin (41) adapted to engage the lost motion slot (33). A tool carrier (42) forms a pair of spaced flat tines (43) and forms a bearing surface (44) in the bight. The upper tine (43) and the bearing surface (44) section are slotted at (45) to allow the passage of a control link (46). Apertures (47) in the tines (43) engage pins (50) on the trunnion body (37). The bar of a generally H-shaped tool assembly (52) comprises a bearing surface (53) running in the bearing surface (44). A crank portion (54) is connected to the control link (46) via crank pin (55).