Abstract: Toric contact lenses employing a stabilization mechanism to minimize the effect of asymmetric eyelid bias in settled orientation of the toric contact lens, and related methods of design. The toric contact lens includes stabilization zones that are each disposed horizontal sides of the lens periphery of the contact lens between its central optic zone and the lens edge. To minimize the effect of asymmetric bias of an eyelid of a patient wearer on the alignment of the toric contact lens to the principal meridians of the eye, the portion of the contour lines in the stabilization zones that are configured to intersect with an upper eyelid margin in wear are oriented to a target upper eyelid margin shape of a target upper eyelid of an average patient wearer. In this manner, the stabilization zone of the toric contact lens is more desensitized to any asymmetric shape of the wearer's eyelid.

Abstract: An intraocular lens (IOL) injector cartridge having one or more modifications from conventional designs which reduce stress and strain in the optic of the IOL during passage through the cartridge. One change includes adding axially-oriented ribs in a funnel portion of the cartridge to enable the cartridge wall to flex outward during passage of the IOL, which is compressed to a great degree in the cartridge lumen. Another modification involves providing a longitudinal step along a segment of the inner lumen which biases one free edge of the optic to tuck or dive under the other free edge and encourage spiral folding as the IOL progresses along the gradually narrowing lumen. The third option is modifying the shape of the lumen within the extreme distal end of the cartridge where the lumen is smallest so that it is neither circular nor oval. Each or all of these modifications may be incorporated into a single cartridge.

Abstract: A method of operating an Internet of Things (IoT) device, the IoT device capable of communicating with a third-party system in order to perform an autonomous task subject to authorisation by an IoT authorisation device, the method comprising: sending operating parameters relating to the autonomous task to a user for approval; receiving user-approved operating parameters for the autonomous task; configuring the IoT device to perform the autonomous task within the user approved operating parameters; registering the user approved operating parameters with the IoT device management server to enable the IoT authorisation device to check that the IoT device is operating within the user-approved operating parameters when it performs an autonomous task with the third-party system.

Abstract: Ophthalmic lenses are described herein. An example ophthalmic lens may comprise a first surface. The example ophthalmic lens may comprise a second surface disposed opposite the first surface. The second surface may be configured to abut at least a portion of an eye of a wearer. The example ophthalmic lens may comprise a lens stabilization zone disposed adjacent the first surface. At least a contour of the lens stabilization zone may be configured to minimize a recovery time for the ophthalmic lens to orient to a resting position from a misaligned position.

Abstract: The invention provides an improved rotationally stabilized contact lens design and method of designing such a lens which minimizes stabilization time of the lens while maximizing the lens on-eye comfort. The lens and the method of designing the lens further improves upon an earlier method which utilizes and combines non-circularity and thickness differential aspects which results in equivalent or minimized stabilization time, ease of insertion and manufacturability as well as maximum comfort that is improved over that of what either aspect can achieve independently. This further improvement of stiffness profile is achieved by optimizing and selectively addressing thickness differential both diametrically and circumferentially in a non-round lens design.

Abstract: Ophthalmic lenses are described herein. An example ophthalmic lens may comprise a first surface. The example ophthalmic lens may comprise a second surface disposed opposite the first surface. The second surface may be configured to abut at least a portion of an eye of a wearer. The example ophthalmic lens may comprise a lens stabilization zone disposed adjacent the first surface. At least a contour of the lens stabilization zone may be configured to minimize a recovery time for the ophthalmic lens to orient to a resting position from a misaligned position.

Abstract: Ophthalmic lenses are described herein. An example ophthalmic lens may comprise a first surface. The example ophthalmic lens may comprise a second surface disposed opposite the first surface. The second surface may be configured to abut at least a portion of an eye of a wearer. The example ophthalmic lens may comprise a lens stabilization zone disposed adjacent the first surface. At least a contour of the lens stabilization zone may be configured to minimize a recovery time for the ophthalmic lens to orient to a resting position from a misaligned position.

Abstract: The invention provides an improved rotationally stabilized contact lens design and method of designing such a lens which minimizes stabilization time of the lens while maximizing the lens on-eye comfort. The lens and the method of designing the lens further improves upon an earlier method which utilizes and combines non-circularity and thickness differential aspects which results in equivalent or minimized stabilization time, ease of insertion and manufacturability as well as maximum comfort that is improved over that of what either aspect can achieve independently. This further improvement of stiffness profile is achieved by optimizing and selectively addressing thickness differential both diametrically and circumferentially in a non-round lens design.

Abstract: A dose control mechanism for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger and a longitudinally extending channel of a housing. The engaging screw thread arrangement includes at least one thread segment and a pitch guide including a variable pitch thread. At least a portion of the longitudinally extending channel of the housing including one of the pitch guide and the at least one thread segment, and the plunger includes the other of the pitch guide and the at least one thread segment. The plunger resides at least partially within the housing with the at least one thread segment engaged with the pitch guide. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle.

Abstract: A dose control mechanism for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger and a longitudinally extending channel of a housing. The engaging screw thread arrangement includes at least one thread segment and a pitch guide including a variable pitch thread. At least a portion of the longitudinally extending channel of the housing including one of the pitch guide and the at least one thread segment, and the plunger includes the other of the pitch guide and the at least one thread segment. The plunger resides at least partially within the housing with the at least one thread segment engaged with the pitch guide. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle.

Abstract: A process for preparing a polymer of an ethylenically unsaturated monomer, in which the monomer is obtainable from a biocatalysed reaction or a fermentation process, and wherein the monomer contains cellular material and/or components of a fermentation broth, forming the polymer by polymerizing the ethylenically unsaturated monomer or a monomer mixture comprising the ethylenically unsaturated monomer, wherein there is substantially no removal of the cellular material and/or components of the fermentation broth from the ethylenically unsaturated monomer.

Abstract: A multi-optic accommodating intraocular lens (A-IOL) for implantation in a capsular bag of an eye having an optical axis, includes a posterior component, an anterior component that is translatable relative to the posterior component along an optical axis of the A-IOL, and a biasing element that joins at least a portion of the anterior component and at least a portion of the posterior component. The A-IOL is quantitatively characterized by an axial compression characteristic such as a spring constant or an axial restoring force. The axial compression characteristic is capable of keeping the components sufficiently vaulted apart for enabling near vision yet weak enough to allow the eye's accommodative mechanism to pull the optics close together for distance vision.

Abstract: A multi-component accommodating intraocular lens (AIOL), comprising a recessed anterior optical element, a posterior component, and at least two longitudinal haptics each coupled to at least a portion of the anterior optic and at least a portion of the posterior component. Each haptic has an anterior most-portion that is disposed more anteriorly than a corresponding portion of an edge of the anterior optical element.

Abstract: A process for preparing a polymer of an ethylenically unsaturated monomer, in which the monomer is obtainable from a biocatalysed reaction or a fermentation process, and wherein the monomer contains cellular material and/or components of a fermentation broth, forming the polymer by polymerising the ethylenically unsaturated monomer or a monomer mixture comprising the ethylenically unsaturated monomer, wherein there is substantially no removal of the cellular material and/or components of the fermentation broth from the ethylenically unsaturated monomer.

Abstract: A multi-component accommodating intraocular lens (A-IOL) for implantation in a capsular bag of an eye having an optical axis, includes an anterior optical element and a posterior component that are connected by at least one compressible haptic. The compressible haptic, by definition, has a deformation feature that is resiliently deformable. The deformation feature allows the nominal overall diameter of the A-IOL to dynamically vary over a selected range in response to a capsular bag dimension that is different than that of an average population value, or in response to a change in the size and/or shape of the capsular bag due to post-operative capsular bag shrinkage, without substantially changing the separation distance between the anterior and posterior components of the A-IOL absent an intended accommodating force. Methods are also disclosed.

Abstract: A thin intraocular lens for inhibiting posterior capsular opacification (PCO) includes an optic having a sharp edge which extends posteriorly and between a posterior concave region and an outer-most peripheral edge surface that extends parallel to the optical axis.

Abstract: The present invention provides a holder/package for supporting a two optic accommodating intraocular lens device. The holder/package is capable of holding the device, for example while taking measurements or performing manufacturing process steps on the device and/or for packaging and shipping of the device. In a preferred embodiment, the holder/package supports the device along first and second haptics thereof with the optics substantially untouched by the holder/package.

Abstract: A method, lens and assembly are disclosed for making a dual optic AIOL from a lens blank having first and second optics and at least one haptic extending therebetween larger in area than the haptic(s) of the finished AIOL. Material is removed from the semi-finished haptic to form the finished haptic of any desired configuration.