Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: A method, apparatus, and article of manufacture are disclosed that provide an efficient and non-ambiguous differentiation and subsequent selection of a single virtual element displayed in close proximity with multiple other virtual elements on a two-dimensional graphics display. A large number of virtual element selection elements are possible at a single two-dimensional display location of a virtual three-dimensional space. The differentiation tool displays a large number of selection possibilities in a small screen size and substantially linear format such that rapid and non-ambiguous graphic selections are possible.