Patents by Inventor Gary Ruvkun

Gary Ruvkun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION
    Publication number: 20250281550
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Application
    Filed: March 26, 2025
    Publication date: September 11, 2025
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary RUVKUN, J. Amaranath GOVINDAN, Elamparithi JAYAMANI
  • Compositions and methods for improving mitochondrial function
    Patent number: 12285446
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Grant
    Filed: July 12, 2023
    Date of Patent: April 29, 2025
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, J. Amaranath Govindan, Elamparithi Jayamani
  • METHODS AND COMPOSITIONS FOR INHIBITING DETOXIFICATION RESPONSE
    Publication number: 20250043286
    Abstract: Disclosed herein are compositions and methods for attenuating detoxification response and related symptoms thereof induced by translation defect. The compositions and methods herein are useful for attenuating detoxification response and/or treat related symptoms thereof in subjects comprising translation defect. The composition and methods herein are also useful for improving pharmacokinetics of a pharmaceutical compound.
    Type: Application
    Filed: July 9, 2024
    Publication date: February 6, 2025
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary RUVKUN, J. Amaranath GOVINDAN
  • Methods and compositions for inhibiting detoxification response
    Patent number: 12065648
    Abstract: Disclosed herein are compositions and methods for attenuating detoxification response and related symptoms thereof induced by translation defect. The compositions and methods herein are useful for attenuating detoxification response and/or treat related symptoms thereof in subjects comprising translation defect. The composition and methods herein are also useful for improving pharmacokinetics of a pharmaceutical compound.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: August 20, 2024
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, J. Amaranath Govindan
  • COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION
    Publication number: 20240082315
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Application
    Filed: July 12, 2023
    Publication date: March 14, 2024
    Applicant: The General Hospital Corporation
    Inventors: Gary RUVKUN, J. Amaranath Govindan, Elamparithi Jayamani
  • Compositions and methods for improving mitochondrial function
    Patent number: 11738056
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: August 29, 2023
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary Ruvkun, J. Amaranath Govindan, Elamparithi Jayamani
  • COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION
    Publication number: 20210213074
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Application
    Filed: March 9, 2021
    Publication date: July 15, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary RUVKUN, J. Amaranath GOVINDAN, Elamparithi JAYAMANI
  • METHODS AND COMPOSITIONS FOR INHIBITING DETOXIFICATION RESPONSE
    Publication number: 20210207141
    Abstract: Disclosed herein are compositions and methods for attenuating detoxification response and related symptoms thereof induced by translation defect. The compositions and methods herein are useful for attenuating detoxification response and/or treat related symptoms thereof in subjects comprising translation defect. The composition and methods herein are also useful for improving pharmacokinetics of a pharmaceutical compound.
    Type: Application
    Filed: March 22, 2021
    Publication date: July 8, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary Ruvkun, J. Amaranath Govindan
  • Methods and compositions for inhibiting detoxification response
    Patent number: 10988765
    Abstract: Disclosed herein are compositions and methods for attenuating detoxification response and related symptoms thereof induced by translation defect. The compositions and methods herein are useful for attenuating detoxification response and/or treat related symptoms thereof in subjects comprising translation defect. The composition and methods herein are also useful for improving pharmacokinetics of a pharmaceutical compound.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: April 27, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary Ruvkun, J. Amaranath Govindan
  • Compositions and methods for improving mitochondrial function
    Patent number: 10973860
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: April 13, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary Ruvkun, J. Amaranath Govindan, Elamparithi JAYAMANi
  • COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION
    Publication number: 20190255124
    Abstract: Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
    Type: Application
    Filed: March 6, 2019
    Publication date: August 22, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary RUVKUN, J. Amaranath Govindan, Elamparithi Jayamani
  • METHODS AND COMPOSITIONS FOR INHIBITING DETOXIFICATION RESPONSE
    Publication number: 20190024080
    Abstract: Disclosed herein are compositions and methods for attenuating detoxification response and related symptoms thereof induced by translation defect. The compositions and methods herein are useful for attenuating detoxification response and/or treat related symptoms thereof in subjects comprising translation defect. The composition and methods herein are also useful for improving pharmacokinetics of a pharmaceutical compound.
    Type: Application
    Filed: August 29, 2016
    Publication date: January 24, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary Ruvkun, J. Amaranath Govindan
  • Therapeutic and diagnostic tools for impaired glucose tolerance conditions
    Patent number: 7414169
    Abstract: Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: August 19, 2008
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, Koutarou Kimura, Garth Patterson, Scott Ogg, Suzanne Paradis, Heidi Tissenbaum, Jason Morris, Allison Koweek
  • Compositions and Methods That Enhance Rna Interference
    Publication number: 20080139492
    Abstract: The invention features nucleobase oligomeric compositions useful in enhancing RNA interference in a wide variety of cell types for the treatment of virtually any disease or disorder related to the overexpression of a gene or genes, as well as methods of identifying and using such compositions.
    Type: Application
    Filed: February 2, 2005
    Publication date: June 12, 2008
    Applicant: The General Hospital Corporation
    Inventors: Gary Ruvkun, Scott Kennedy
  • Methods and Compositions Relating to Lipid Accumulation
    Publication number: 20080064648
    Abstract: In general, this invention relates to nucleic acid and amino acid sequences involved in lipid accumulation, screening methods for identifying genes that regulate lipid accumulation, and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases.
    Type: Application
    Filed: June 16, 2004
    Publication date: March 13, 2008
    Applicant: The General Hospital Corporation
    Inventors: Gary Ruvkun, Ho Yi Mak
  • Polynucleotide and polypeptide fat metabolism regulators and uses thereof
    Publication number: 20070087378
    Abstract: In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat metabolism and the development of treatments for obesity and obesity-related diseases.
    Type: Application
    Filed: December 19, 2006
    Publication date: April 19, 2007
    Applicant: The General Hospital Corporation
    Inventors: Gary Ruvkun, Kaveh Ashrafi
  • Polynucleotide and polypeptide fat metabolism regulators and uses thereof
    Patent number: 7175999
    Abstract: In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat metabolism and the development of treatments for obesity and obesity-related diseases.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: February 13, 2007
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, Kaveh Ashrafi
  • AGE-1 polypeptides and related molecules and methods
    Patent number: 7094889
    Abstract: Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: August 22, 2006
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, Jason Morris, Heidi Tissenbaum
  • Methods and compositions of ecdysozoan molt inhibition
    Publication number: 20060178292
    Abstract: In general, this invention relates to nucleic acid and amino acid sequences involved in molting and the use of these sequences as targets for the development of compounds that disrupt Ecdysozoan molting, and are useful as insecticides, nematicides, and anti-parasitic agents.
    Type: Application
    Filed: December 31, 2003
    Publication date: August 10, 2006
    Applicant: The General Hospital Corporation
    Inventors: Gary Ruvkun, Alison Frand
  • Therapeutic and diagnostic tools for impaired glucose tolerance conditions
    Patent number: 7041437
    Abstract: Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: May 9, 2006
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, Scott Ogg