Patents by Inventor Gary S. David

Gary S. David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120238466
    Abstract: In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may be singulated to be read by the optical detector one at a time.
    Type: Application
    Filed: May 23, 2012
    Publication date: September 20, 2012
    Applicant: IRORI TECHNOLOGIES, INC.
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Patent number: 8219327
    Abstract: In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may besingulated to be read by the optical detector one at a time.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: July 10, 2012
    Assignee: Irori Technologies, Inc.
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Publication number: 20110237459
    Abstract: In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may be singulated to be read by the optical detector one at a time.
    Type: Application
    Filed: June 10, 2011
    Publication date: September 29, 2011
    Applicant: NEXUS BIOSYSTEMS, INC.
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Publication number: 20110212857
    Abstract: In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may besingulated to be read by the optical detector one at a time.
    Type: Application
    Filed: May 2, 2011
    Publication date: September 1, 2011
    Applicant: NEXUS BIOSYSTEMS, INC.
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Patent number: 7935659
    Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: May 3, 2011
    Assignee: Nexus Biosystems, Inc.
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Patent number: 6372428
    Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: April 16, 2002
    Assignee: Discovery Partners International, Inc.
    Inventors: Michael P. Nova, Andrew E. Senyei, Gary S. David
  • Patent number: 6331273
    Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 18, 2001
    Assignee: Discovery Partners International
    Inventors: Michael P. Nova, Andrew E. Senyei, Gary S. David
  • Patent number: 6319668
    Abstract: Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: November 20, 2001
    Assignee: Discovery Partners International
    Inventors: Michael P. Nova, Hanan Potash, Xiao-Yi Xiao, Zahra Parandoosh, Gary S. David
  • Patent number: 6306975
    Abstract: Methods for irradiation induced graft polymerization of a monomers, such as styrenes, onto fluoropolymers are provided. The methods, which involve either the use of acids, preferably mineral acids, or creating a rough surface on the fluoropolymer, provide higher levels of grafting of the copolymer than grafting in the absence of the acid or of the rough surface on the fluoropolymer. Also provided are grafted copolymers produced by the methods. Methods for increasing the performance of solid phase assays, such as scintillation proximity assays, are also provided.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: October 23, 2001
    Assignee: Irori
    Inventors: Chanfeng Zhao, John E. Lillig, Robert Neeper, Gordon W. Hudson, Anthony W. Czarnik, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Patent number: 6025129
    Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: February 15, 2000
    Assignee: Irori
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David
  • Patent number: 6017496
    Abstract: Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: January 25, 2000
    Assignee: Irori
    Inventors: Michael P. Nova, Zahra Parandoosh, Andrew E. Senyei, Xiao-Yi Xiao, Gary S. David, Yozo Satoda, Chanfeng Zhao, Hanan Potash
  • Patent number: 5961923
    Abstract: Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: October 5, 1999
    Assignee: Irori
    Inventors: Michael P. Nova, Zahra Parandoosh, Andrew E. Senyei, Xiao-Yi Xiao, Gary S. David, Yozo Satoda, Chanfeng Zhao, Hanan Potash
  • Patent number: 5925562
    Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 20, 1999
    Assignee: Irori
    Inventors: Michael P. Nova, Andrew E. Senyei, Gary S. David
  • Patent number: 5439829
    Abstract: A chelating agent is covalently bonded to a biologically active molecule such as an enzyme or antibody, the biologically active molecule is contacted with a support containing a bound transition metal ion whereby the metal ion is chelated by the chelating agent and the oxidation state of the metal ion is changed by treatment with an oxidizing or a reducing agent to provide a kinetically inert: oxidation state to immobilize the biologically active molecule on the support. The transition metal ion is preferably Co(II), Cr(II) or Ru(III) and the oxidation state of the metal ion is changed to Co(III), Cr(III) or Ru(II), respectively. The chelating agent can be iminodiacetic acid, nitrilotriacetic acid, terpyridine, bipyridine, triethylenetetraamine, biethylenetriamine, 1,4,7-triazacyclonane or a chelating peptide. Certain chelating agents can immobilize more than one biologically active molecule at a metal ion site on the support.
    Type: Grant
    Filed: January 24, 1992
    Date of Patent: August 8, 1995
    Assignees: Eli Lilly and Company, Hybritech Incorporated
    Inventors: Leslie D. Anderson, James A. Cook, Gary S. David, Susan M. Hochschwender, Mary S. Kasher, Michele C. Smith, Willem P. C. Stemmer
  • Patent number: 4722892
    Abstract: Monoclonal Antibodies which are specific for a complex of a chelating agent and a metallic ion are described. The antibody has an association constant (K.sub.a) for the complex which is at least about ten times greater than the K.sub.a for the chelating agent alone or its complex with another metal.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: February 2, 1988
    Inventors: Claude F. Meares, Gary S. David
  • Patent number: 4486530
    Abstract: "Two-site" or "sandwich" immunometric assay techniques for determination of the presence and/or concentration of antigenic substances in fluids using monoclonal antibodies are described and compared to conventional assays using polyclonal antibodies. Also described are inhibition assays using complexes of antigens with a monoclonal antibody.
    Type: Grant
    Filed: June 24, 1981
    Date of Patent: December 4, 1984
    Assignee: Hybritech Incorporated
    Inventors: Gary S. David, Howard E. Greene
  • Patent number: 4376110
    Abstract: "Two-site" or "sandwich" immunometric assay techniques for determination of the presence and/or concentration of antigenic substances in fluids using monoclonal antibodies. One monoclonal antibody is presented in a soluble labeled form and a second monoclonal antibody is presented bound to a solid carrier; the soluble and bound monoclonal antibodies may be the products of either the same or different cell lines. Each monoclonal antibody has an affinity for the antigenic substances of at least about 10.sup.8 liters/mole.
    Type: Grant
    Filed: August 4, 1980
    Date of Patent: March 8, 1983
    Assignee: Hybritech, Incorporated
    Inventors: Gary S. David, Howard E. Greene