Patents by Inventor Gary S. Firestein

Gary S. Firestein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapy for cellular accumulation in chronic inflammatory diseases
    Publication number: 20040116372
    Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.
    Type: Application
    Filed: November 18, 2003
    Publication date: June 17, 2004
    Applicant: The Regents of the University of California
    Inventors: Gary S. Firestein, Nathan J. Zvaifler, Douglas R. Green
  • Therapy for cellular accumulation in chronic inflammatory diseases
    Patent number: 6747013
    Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: June 8, 2004
    Assignees: The Regents of the University of California, La Jolla Institute for Allergy and Immunology
    Inventors: Gary S. Firestein, Nathan J. Zvaifler, Douglas R. Green
  • Methods of ameliorating arthritis by modulating JNK signalsome activity
    Publication number: 20030068660
    Abstract: Methods for identifying an agent that modulates JNK signalsome mediated signal transduction are provided. As provided are methods of ameliorating an arthritis in a subject by inhibiting JNK signalsome activity in cells of the subject.
    Type: Application
    Filed: September 10, 2002
    Publication date: April 10, 2003
    Inventor: Gary S. Firestein
  • THERAPY FOR CELLULAR ACCUMULATION IN CHRONIC INFLAMMATORY DISEASES
    Publication number: 20020031496
    Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.
    Type: Application
    Filed: July 29, 1999
    Publication date: March 14, 2002
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: GARY S. FIRESTEIN, NATHAN J. ZVAIFLER, DOUGLAS R. GREEN
  • Methods for treating arthritis by administering an apoptosis regulator
    Patent number: 6004942
    Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: December 21, 1999
    Assignee: The Regents of the University of California
    Inventors: Gary S. Firestein, Nathan J. Zvaifler, Douglas R. Green
  • Methods for treating adenosine kinase related conditions
    Patent number: 5646128
    Abstract: Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: July 8, 1997
    Assignee: Gensia, Inc.
    Inventors: Gary S. Firestein, Bheemarao G. Ugarkar, Leonard P. Miller, Harry E. Gruber, David A. Bullough, Mark D. Erion, Angelo J. Castellino, Clinton E. Browne