Abstract: Provided herein are methods of treating ocular cancer such as uveal melanoma, orbital lymphoma, retinoblastoma, and medulloepithelioma using antibodies and bispecific antigen-binding molecules that bind MET or antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different epitopes of the extracellular domain of human MET. The ADCs comprise the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety. The antibodies and bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. A subject having ocular cancer, for example, an uveal melanoma expressing c-Met, can be treated by administering to the subject an antibody, a bispecific antigen-binding molecule, or an ADC thereof.

Abstract: Disclosed are systems, methods, and products for creating, organizing, storing, archiving and publishing content and data points on a real-time basis based on multiple inputs from different sources, including the creation of content and data within the application, the creation of related or summary content and data on social media platforms, the facilitation of non-curated external interactions on social media platforms about, or related to, the curated content and data, and the inclusion of content and data extracted from social media platforms in response to related or summary content and data. The system, methods and products permit variable content moderation during the content creation process dependent on assigned roles. These systems and methods permit assignment of roles for the purpose of curated interactions and allow for content from multiple content providers to be juxtaposed in a dialogue or interview or debate format rather than individual, concatenated feeds.

Abstract: The present disclosure describes systems and methods for a patient arm support system for medical procedures such as radial catheterization. The support system has a body support board upon which a patient's body rests and an arm support board upon which the patient's arm rests. A pivot plate is provided that is connected to the body support board by a radial pivot hinge such that the pivot plate is rotatable throughout various rotational angles, (?), relative to the body support board. The support system may have an elevational hinge connecting the pivot plate and the arm support board such that the arm support board can be elevated an elevational angle (?) from the pivot plate. The support system may have an arm board stand. The support system may have a rotational bearing material between the pivot plate and the body support board.

Abstract: An airborne substance detector includes an air intake that sweeps through a fixed area, and a fan that draws air toward an effluence detection device that analyzes the air for one or more substances, such as explosives. The air intake may be a series of tubes of a rotary gate, with multiple sets of tubes that rotate about a central axis. The fan or blower draws air through holes in the tubes, and through a manifold that directs air to the effluence detection device from a single set of tubes at a time. In addition the detector may include a heater that may enhance vaporization of substances to be detected. The effluence detection device, the manifold, and the fan may be located in an enclosure at the top of the rotary gate. After detection, a decontamination procedure may be initiated to purge the system of the substance that was detected.

Abstract: An airborne substance detector includes an air intake that sweeps through a fixed area, and a fan that draws air toward a effluence detection device that analyzes the air for one or more substances, such as explosives. The air intake may be a series of tubes of a rotary gate, with multiple sets of tubes that rotate about a central axis. The fan or blower draws air through holes in the tubes, and through a manifold that directs air to the effluence detection device from a single set of tubes at a time. In addition the detector may include a heater that may enhance vaporization of substances to be detected. The effluence detection device, the manifold, and the fan may be located in an enclosure at the top of the rotary gate. After detection, a decontamination procedure may be initiated to purge the system of the substance that was detected.

Abstract: An apparatus, system and method for multi-orientation single or two phase coldplate with positive flow characteristics is disclosed. In representative embodiments and applications, the present invention generally provides improved methods and systems for cooling through fluid cooled coldplates.

Abstract: The present invention relates to heat exchangers, and more particularly to a heat exchange apparatus configured to operate in a free air stream. In an embodiment, a heat exchange apparatus configured to operate in a free air stream includes a heat exchange structure having a shape configured to conform to a body of a vehicle when in a stowed condition; and a deployment mechanism for moving the heat exchange structure to a deployed condition external to the vehicle. The heat exchange structure has a curved surface that is concave into the air stream when the heat exchange structure is in the deployed condition.

Abstract: The present invention relates to heat exchangers, and more particularly to a heat exchange apparatus configured to operate in a free air stream. In an embodiment, a heat exchange apparatus configured to operate in a free air stream includes a heat exchange structure having a shape configured to conform to a body of a vehicle when in a stowed condition; and a deployment mechanism for moving the heat exchange structure to a deployed condition external to the vehicle. The heat exchange structure has a curved surface that is concave into the air stream when the heat exchange structure is in the deployed condition.

Abstract: The present invention relates to heat exchangers, and more particularly to a heat exchange structure configured to operate in an air stream. In one embodiment, a heat exchange structure configured to operate in an air stream includes coolant flow portions, each of the coolant flow portions having at least one substantially closed surface directed into the air stream; and air flow portions disposed between adjacent coolant flow portions for receiving air from the air stream, the air flow portions having air passages directed into the air stream; the substantially closed surface of the coolant flow portions having an aerodynamic shape.

Abstract: The invention provides methods and systems for guiding an interventional medical procedure using ultrasound imaging. Using improved image fusion techniques, the invention provides an improved method for the treatment of a flexible target volume and/or flexible surrounding structures.

Abstract: An apparatus, system and method for multi-orientation single or two phase coldplate with positive flow characteristics is disclosed. In representative embodiments and applications, the present invention generally provides improved methods and systems for cooling through fluid cooled coldplates.

Abstract: Disclosed is a method and system for determining the location of at least one of a plurality of uniquely-identified transducers within one of a plurality of known areas (210-270). The method comprises the steps of receiving information from at least one sensor selected from a plurality of first (211, 212, 216) and second sensors (218, 228, 238), wherein the first sensors (211, 212, 216) are distributed within the plurality of known areas, and the second sensors are located between adjacent ones of the plurality of known areas (220, 240), the information including at least a transducer-unique identification, associating the received information based on the transducer identification, and determining the location based on the information received by at least one of the first sensors. In one aspect the information is a signal strength. In another aspect of the invention, the location may be determined based on information received by a plurality of the first sensors.

Abstract: A nightlight according to the invention may comprise a base; a lighting device on the base; and a power source in the base for the lighting device; an outer housing mounted on the base and surrounding the lighting device, having a window through which light can project from the lighting device; an image support within the outer housing for holding at least one image between the lighting device and the window, whereby the image is illuminated by the lighting device and visible through the window. The image support may be rotatably mounted within the outer housing, and capable of supporting a plurality of images and of being selectively rotated into a position for displaying a selected one of the images through the window. The image support may be a cylindrical drum. The image support may be rotatable by a ring which is accessible by a user for manually rotating the drum. The image may be a pictorial image or may be formed by perforations formed in the image support.

Abstract: In an ultrasonic diagnostic imaging system which scans a volumetric region, the sampling bandwidth or spatial resolution is matched to the achievable transducer resolution determined by the aperture size and the wavelength and the desired output bandwidth or volume imaging rate. In an illustrated embodiment this is done by controlling the spatial point spread function of the beams used to scan the volumetric region to provide a more optimal relationship between the acoustic sampling resolution, the desired output line density, and the volume imaging rate. The benefits of this optimization can be to maximize the information content and information movement efficiency by not acquiring more resolution than can be utilized, and to provide a more optimal sampling function, using the aperture function to limit the spatial bandwidth.

Abstract: An apparatus includes a thermally conductive section with a side facing approximately parallel to an axis and adapted to be thermally coupled to a circuit component, and includes a fluid supply section which directs a fluid flow along the axis toward an opposite side of the thermally conductive section. The thermally conductive section splits the fluid flow into a plurality of flow portions which each flow through the thermally conductive section in a direction approximately parallel to a plane perpendicular to the axis, the flow portions exiting the thermally conductive section at a plurality of respective locations disposed along a substantial portion of the periphery of the thermally conductive section.

Abstract: A pneumatic locking swivel caster comprises a swivel caster and a locking device which may be activated by fluid pressure. The swivel caster may be a dual wheel swivel caster. An improved theatrical prop or scenery element comprises a pneumatic locking swivel caster and a control system. The control system may comprise a tank filled with pressurized air and a control valve. A pneumatic locking swivel caster may be locked into position by activating the control valve and pressuring the caster with air. The pneumatic locking swivel caster may comprise a triple swivel caster adapted such that all three sets of wheels are locked by air pressure.

Abstract: According to one embodiment of the invention a method for cooling a structure includes flowing a saturated refrigerant through one or more passageways in the structure while maintaining the refrigerant at a substantially constant pressure. The method also includes evaporating at least a portion of the refrigerant at a substantially constant temperature throughout the passageways in the structure.

Abstract: A portable computer includes a housing containing a circuit component, and a temperature adjusting arrangement which has a thermally conductive section with a side facing approximately along an axis and thermally coupled to the component. A fluid supply section directs a fluid flow along the axis and the thermally conductive section splits the fluid flow into a plurality of flow portions which each flow through the thermally conductive section in a direction approximately parallel to a plane perpendicular to the axis, the flow portions exiting the thermally conductive section at a plurality of respective locations disposed along a substantial portion of the periphery of the thermally conductive section.

Abstract: A diagnostic ultrasonic imaging system includes a scanhead having a plurality of transducer elements. A signal combiner, such a time-division multiplexer or a frequency-division multiplexer, is coupled to each of the transducer elements. The signal combiner combines the signals from the transducer elements into a composite signal and couples the composite signal to an ultrasonic processor through a wire or other communication link. A signal separator, such as a time-division demultiplexer or a frequency-division demultiplexer, is coupled to the link and recovers from the composite signal each of the signals from the transducer elements.

Abstract: A receive beamformer, and ultrasound system incorporating such a receive beamformer, is constructed to implement multi-bit analog to digital conversion in such a way that the need for gain control in the channel architecture preceding the digital conversion circuitry is obviated. Accordingly, the beamformer and any ultrasound system incorporating it may realize a rigorous level of ADC performance at desirable output rates, and a lower cost. Preferably, the invention construction realizes a level of performance by which CW Doppler may be digitized in the same manner as very wide-band pulsed-wave signals.