Abstract: The present disclosure is directed to compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions. Methods include administering a pharmaceutical composition comprising an autophagy modulating agent selected from formulas as defined herein.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions and compositions of photoreactive compounds. An aspect of the present disclosure provides for autophagy enhancing agents capable of treating or preventing diseases, disorders, or conditions in which autophagy is implicated.

Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.

Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.

Abstract: Improved methods, systems, and software are provided for facilitating debt collection by utilizing a non-term life insurance policy for making payments due by debtors to creditors. The life insurance policy can be implemented as, or in conjunction with, a sinking fund for maintaining premium payments received from a debtor under the policy. Periodic and/or lump sum payments to the creditor on behalf of the debtor can be made from the sinking fund, allowing the creditor to receive satisfaction of the debt. Various features can be implemented to provide for the entire amount of debt owed by the debtor to the creditor and further provide cash flow to the creditor after an initial period of contribution. In the event of death of the debtor, the creditor can receive full payment for the outstanding debt.

Abstract: This invention relates to polymers for self-polishing marine antifouling coatings. More particularly, the invention relates to polymer binders, which provide an erosion rate in seawater that is suitable for use in marine antifouling coatings. These polymer binders contain pendant benzylsilylacrylate groups. Additionally it was found that marine antifouling coatings could be formed with lower silyl acrylate levels using the monomers of the invention, and still achieve a suitable erosion rate in seawater.

Abstract: The present invention relates to triorgano phosphites, triorgano amines, heteroaromatic nitrogen compounds, and carbodiimides used as stabilizers for hydrolyzable organic binders. The stabilizers help to prevent viscosity thickening of polymeric binders containing carboxylic ester groups. Without stabilization, the binders can rapidly thicken when exposed to moisture air. The stabilized organic binders of the invention are especially useful for formulating marine antifoulant coatings.

Abstract: The present invention relates to environmentally sensitive organic binders stabilized by maleic anhydride and its derivatives. The unstabilized binders can rapidly hydrolyze and thicken when exposed to the environment, and especially to moisture. Maleic anhydride and its derivatives act to stabilize these binders. The stabilized organic binders of the invention are especially useful for forming marine antifoulant coatings.

Abstract: A self-contained electronic unit includes a physically manipulable housing such as a mouse, a feedback device, and processing electronics. The housing is constructed to be moved in its entirety during use by a user. The feedback device is incorporated into the housing and is configured to communicate, to the user, movement of a virtual object within a virtual environment. The processing electronics are incorporated into the housing, and are configured to generate the virtual environment, to respond to movement of the housing in its entirety, without regard to relative movement of the housing with respect to any stationary attached hardware, by causing movement of the virtual object within the virtual environment. A trackball is contained within the mouse housing, and the processing electronics are configured to respond to direct physical manipulation of the trackball by a user to cause movement of the virtual object within the virtual environment.