Patents by Inventor Gary Stiles

Gary Stiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Irreversible inhibitors of adenosine receptors
    Patent number: 5545627
    Abstract: Irreversible ligands for adenosine receptors are derived from agonist and antagonist functionalized congeners which contain electrophilic acylating and alkylating groups for reaction at nucleophilic residues of adenosine receptors. The ligands are based on 8-aryl-substituted xanthines as antagonists and on N.sup.6 -substituted adenosine as agonists.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: August 13, 1996
    Assignees: The United States of America as represented by the Department of Health and Human Services, Duke University
    Inventors: Kenneth A. Jacobson, Gary Stiles
  • Irreversible inhibitors of adenosine receptors
    Patent number: 5298508
    Abstract: Irreversible ligands for adenosine receptors are derived from agonist and antagonist functionalized congeners which contain electrophilic acylating and alkylating groups for reaction at nucleophilic residues of adenosine receptors. The ligands are based on 8-aryl-substituted xanthines as antagonists and on N.sup.6 -substituted adenosine as agonists, wherein the electrophlic group may be, for example, isothiocyanate and N-hydroxysuccinimide esters.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: March 29, 1994
    Assignees: The United States of America as represented by the Department of Health and Human Services, Duke University
    Inventors: Kenneth A. Jacobson, Gary Stiles