Patents by Inventor Gary Thomas Borrett

Gary Thomas Borrett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel processes for the preparation of 4-phenylpiperidine derivatives
    Publication number: 20040087795
    Abstract: A process for preparing compound (E) from compound (A), with or without isolation of intermediate products, characterised by one or more of the following steps:
    Type: Application
    Filed: June 24, 2003
    Publication date: May 6, 2004
    Inventors: Gary Thomas Borrett, Michael Fedouloff, Mark Jason Hughes, Andrew Colin Share, John Bryce Strachan, Peter Szeto, Martyn Voyle
  • Enantiomer of carbazole derivative as 5-HT1-like agonists
    Patent number: 5962501
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: October 5, 1999
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • Process for preparing enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
    Patent number: 5917054
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: January 6, 1997
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • Process for the preparation of azabicyclic derivatives
    Patent number: 5808075
    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R.sub.1 represents (a) in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; and R.sub.3 is CN; said process comprising reacting a compound of formula (II) wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: September 15, 1998
    Inventors: Steven Mark Bromidge, Martyn Voyle, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Gary Thomas Borrett
  • Process for the preparation of azabicycloc derivatives
    Patent number: 5773619
    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 represents ##STR2## in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1;R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; andR.sub.3 is CN;said process comprising reacting a compound of formula (II): ##STR3## wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 30, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Mark Bromidge, Martyn Voyle, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Gary Thomas Borrett
  • Derivatives of quinuclidine n-oxide as muscarinic receptor ligands
    Patent number: 5675007
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof (I) wherein R.sub.1 represents (a), R.sub.2 is a group OCH.sub.3, and R.sub.3 is cyano, for use in the treatment and/or prophylaxis of dementia in mammals.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: October 7, 1997
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John Keogh, Gary Thomas Borrett, Steven Mark Bromidge, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Martyn Voyle
  • Enantiomers of carbazole derivatives as 5-HT.sub. 1-like agonists
    Patent number: 5650426
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 22, 1997
    Assignee: SmithKline Beecham plc
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young