Abstract: A heat exchanger includes a shell with a longitudinal axis and helical baffles inside the shell and arranged along the longitudinal axis in an alternating pattern of a first baffle followed by a second baffle of the helical baffles. Each helical baffle includes first holes and second holes that receive tubes. The second holes have a diameter larger than the first holes or there is a clearance between the second holes and the tubes that is greater than a clearance between the first holes and the tubes to intentionally induce an increase in a leakage stream in the spaces between the second holes and the tubes. Such increase in the leakage stream maintains a relatively constant rate of heat transfer while reducing pressure drop, thereby resulting in an improved heat transfer to pressure drop ratio for the heat exchanger.

Abstract: The invention relates to peptides, proteins, nucleic acids, and cells for use in immunotherapeutic methods. In particular, the invention relates to the immunotherapy of cancer. The invention provides T cell receptors (TCRs), tumor infiltrating lymphocytes (TILs), and vaccines that recognize HERV-K. The invention provides TCR sequences generated from tumor infiltrating lymphocytes that recognize HERV-K antigens as peptides bound to the Major Histocompatibility Complex (MHC), resulting in an interaction between the HLA-peptide complex and the CDS TCR. Peptides bound to molecules of the MHC, or peptides as such, can also be targets of antibodies, soluble TCRs, and other binding molecules.

Abstract: This invention relates to a process for making phenolic fatty acid compounds having a reduced phenolic ester content. The invention also relates to method for chemically bonding a phenolic resin with a non-phenolic polymer (e.g., a synthetic fabric). The method comprises contacting a phenolic fatty acid compound with a non-phenolic polymer to introduce a hydroxy phenyl functional group into the non-phenolic polymer; and reacting the hydroxy phenyl functional group contained in the non-phenolic polymer with a phenolic resin or a phenolic crosslinker composition capable of forming a phenolic resin, to chemically bond the phenolic resin with the non-phenolic polymer. The invention is particularly useful for making a synthetic fabric-reinforced article, such as synthetic fabric-reinforced rubber article, circuit board substrate, or fiberglass.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions and compositions of photoreactive compounds. An aspect of the present disclosure provides for autophagy enhancing agents capable of treating or preventing diseases, disorders, or conditions in which autophagy is implicated.

Abstract: A method includes error encoding data to produce a plurality of data slices. Metadata is determined for a data slice of the plurality of data slices. The metadata is stored in a metadata storage tree. The data slice is stored in a slice storage location indicated by the metadata. Based on determining to access the data slice, the metadata for the data slice is accessed in the metadata storage tree to determine the slice storage location for the data slice, and the data slice is accessed in the slice storage location based on determining the slice storage location for the data slice via accessing the metadata storage tree.

Abstract: A method and system for controlling a power supply rail. The method includes adjusting a power supply rail for circuit component(s) to a first setting. The method includes determining voltage sample(s) by sampling an input voltage corresponding to an input signal. The method also includes determining whether the voltage sample(s) breach a first or second voltage threshold. Additionally, the method includes adjusting the power supply rail to a second setting if a predetermined quantity of the voltage sample(s) breach the first voltage threshold, wherein a magnitude of the second setting equals or is greater than a magnitude of the first setting; and adjusting the power supply rail to a third setting if the voltage sample(s) are captured during at least a threshold amount of time and do not breach the second voltage threshold. The magnitude of the first setting is greater than a magnitude of the third setting.

Abstract: A game engine is configured to accept human intelligence tasks as in-game content and present the in-game content to the game player. A method performed by the game engine enables performance of human intelligence tasks, such as visual discrimination, in a video game context. The game engine may receive a definition of human intelligence tasks from one or more remote sources. The game engine may present the human intelligence tasks to multiple video game participants as in-game content. The game engine defines and enables game play rules for the in-game content. The game play rules set parameters for the multiple video game participants to perform the human intelligence tasks to achieve desired results. The game engine may award each of the multiple video game participants an improved game score upon successful performance of the human intelligence tasks in accordance with the game play rules. The game engine may measure success by consistency in responses between different participants or trials.

Abstract: One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.

Abstract: A system and method for controlling an ignition system. An ignition coil assembly has an ignition transformer with primary and secondary windings and a local control unit. A spark apparatus is connected with the secondary winding of the ignition transformer. The local control unit is adapted to regulate ignition timing of the ignition transformer for generating a spark at the spark apparatus to ignite a fuel-air mixture in an engine cylinder. A central control unit is in electronic communication with the local control unit for monitoring the ignition transformer.

Abstract: A refuse collection system includes a lift system, a sensor, and a processing circuit. The lift system is configured to lift a refuse container and empty refuse therein into a receptacle of the refuse vehicle. The processing circuit is configured to receive a signal from the sensor, detect a thermal event based on the signal, and control the lift system to stop lifting the refuse container in response to the thermal event being detected.

Abstract: A neuro-symbolic retrieval augmented generation hybrid method includes detecting an incomplete entigen group within a knowledge database. The incomplete entigen group includes entigens and one or more entigen relationships between at least some of the entigens. The incomplete entigen group represents knowledge of a topic. The method further includes obtaining additive content for the topic based on the incomplete entigen group and generating an additive entigen group based on the additive content. The method further includes updating the incomplete entigen group utilizing the additive entigen group to produce an updated entigen group. The method further includes indicating that the updated entigen group has an un-curated status when the additive entigen group conflicts with the incomplete entigen group.

Abstract: A point-of-sale device, including a tamper detection circuit, a processor, and a memory is provided. The tamper detection circuit includes a light sensor. The light sensor includes a phototransistor. The tamper detection circuit is configured to provide a light detection signal based on incident light received by the light sensor. The processor is configured to generate a tamper signal based on the light detection signal. The processor is further configured to initiate a tamper event response according to the tamper signal. The tamper event response may erase a memory or trigger an alarm. The point-of-sale device further includes a substantially opaque internal housing. The internal housing may be substantially opaque. The tamper detection circuit, the processor, and the memory may be arranged within the internal housing.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A vehicle brake system includes a back plate that may support a composite pad, and at least one conditioning insert coupled to the back plate and that may contact a surface of a wheel during a braking event and thereby to condition at least a portion of the surface of the wheel. Optionally, the back plate can define a U-shaped coupler that is centrally located and has two ends that are distal from the coupler. The back plate can have a centerline extending from a first end of the ends to a second end of the ends while passing through a center of the back plate, and the at least one conditioning insert can be disposed off of the centerline so as to not be centrally disposed.

Abstract: A system includes a platform configured to receive a video recording of a flight path of an object and initiate back-end processing of the video recording. The back-end processing may include data modeling, object detection operations, normalizing operations, adjusting normalize data based on meta_camera specifications to compensate for limitations of the user device used to create the video recording, and applying mathematical techniques to the adjusted data to derive metrics relating to the flight path of the object and to generate an enhanced video clip of the flight path. In an embodiment, the back-end processing may further include generating a trace line of the flight path of the object, adding the trace line to the enhanced video clip, transmitting the enhanced video clip and the metrics to the user device, and storing the enhanced video clip and the metrics in back-end storage.

Abstract: A mobile processing system is disclosed for the removal of radioactive contaminants from nuclear process wastewater. The system is fully scalable, modular, and portable allowing the system to be fully customizable according to site-specific remediation requirements. It is designed to be both transported and operated from standard sized intermodal containers or custom designed enclosures for increased mobility between sites and on-site, further increasing the speed and ease with which the system may be deployed. Additionally, the system is completely modular wherein the various modules perform different forms or stages of wastewater remediation and may be connected in parallel and/or in series. Depending on the needs of the site, one or more different processes may be used. In some embodiments, one or more of the same modules may be used in the same operation.

Abstract: A disposable air and water (AW) valve assembly and suction valve assembly for an EUS instrument. The AW assembly includes an AW valve and an endcap for receiving the AW valve therebetween. The AW valve includes an AW stem connected to a valve stem. The suction valve assembly includes a suction valve disposed in a suction endcap. The suction valve also includes a valve stem. The valve stem is disposed between a suction valve opening such that portions of the valve stem extend beyond opposed ends of the suction endcap. The suction valve is formed from a suction stem and a piston connected to the suction stem.

Abstract: There is provided a system, apparatus and methods for enhancing the illumination of structures of the eye using predetermined scan patterns of an illuminating light beam. The systems, apparatus and methods further provide for obtaining enhanced single images of multiple structures of the eye.

Abstract: The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels.

Abstract: The disclosure relates to piezoelectric apparatus containing ionic liquids. The piezoelectric apparatus includes a chamber defining an internal volume containing an ionic liquid therein. The ionic liquid can generate a voltage or current upon application of force to the chamber or cell, thus exhibiting a piezoelectric effect. The ionic liquid also can deform upon application of a voltage to the ionic liquid, thus exhibiting a converse piezoelectric effect. The piezoelectric apparatus further includes first and second electrodes in contact with the ionic liquid at first and second locations, such as at opposing locations in the chamber with the ionic liquid positioned between the electrodes. The piezoelectric apparatus, depending on whether it is configured to exhibit a piezoelectric effect or a converse piezoelectric effect, can form or otherwise be a component of various energy or sensing devices, such as an energy harvester, force sensor, piezo-pneumatic device or actuator, optical sensor, etc.