Abstract: The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.

Abstract: A semiconductor device and a method of fabricating the same, includes vertically stacked layers on an insulator. Each of the layers includes a first dielectric insulator portion, a first metal conductor embedded within the first dielectric insulator portion, a first nitride cap covering the first metal conductor, a second dielectric insulator portion, a second metal conductor embedded within the second dielectric insulator portion, and a second nitride cap covering the second metal conductor. The first and second metal conductors form first vertically stacked conductor layers and second vertically stacked conductor layers. The first vertically stacked conductor layers are proximate the second vertically stacked conductor layers, and at least one air gap is positioned between the first vertically stacked conductor layers and the second vertically stacked conductor layers.

Abstract: The virtual supercomputer is an apparatus, system and method for generating information processing solutions to complex and/or high-demand/high-performance computing problems, without the need for costly, dedicated hardware supercomputers, and in a manner far more efficient than simple grid or multiprocessor network approaches. The virtual supercomputer consists of a reconfigurable virtual hardware processor, an associated operating system, and a set of operations and procedures that allow the architecture of the system to be easily tailored and adapted to specific problems or classes of problems in a way that such tailored solutions will perform on a variety of hardware architectures, while retaining the benefits of a tailored solution that is designed to exploit the specific and often changing information processing features and demands of the problem at hand.

Abstract: A Digital Subscriber Line Access Multiplexer (DSLAM) is modified to monitor when a line synchronizes (i.e. sets up a DSL connection) and to automatically generate a notification to be sent to a management device of the access network if the rate has changed from the last time the line synchronized.

Abstract: A critical path monitor having selectable data output modes provides additional information about critical path delay variation. A pulse is propagated through a synthesized path representing a critical path in a functional logic circuit and a synthesized path delay is measured by a monitoring circuit that detects the arrival of an edge of the pulse at the output of the synthesized delay. The measured delay is provided as a real-time output and a processed result of the measured delay is processed according to a data output mode selected from multiple selectable output modes, thereby providing different information describing the real-time data about critical path delay, such as a range of edge positions corresponding to a variation of the critical path delay.

Abstract: An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain. The cartridge holding the plurality of vials rotates relative to the stationary banks of valves and the waste tube system.

Abstract: A stator comprises a ferromagnetic core having teeth. The stator also comprises first and second insulator members. The first and second insulating members collectively encircle each of the teeth of the core. The first insulating member comprising a plurality of mounting bosses spaced circumferentially from each other about the axis. Each of the mounting bosses has first and second retaining surfaces. The first and second retaining surfaces face axially opposite directions from each other and are exposed and are unobstructed by the second insulating member.

Abstract: A computer-implemented method of introducing users of a service includes sending a suggestion to a first user of a service and suggesting an introduction of a second user to a third user of the service. The second and third users are both identified as contacts of the first user in a contact list of the first user and the second and third users satisfy predefined selection criteria with respect to shared contacts, comprising users identified in contact lists of both the second and third users. The method also includes receiving, from the first user, a response to the suggestion; and upon receiving a positive response to the suggestion from the first user, sending the introduction to at least one of the second and third users.

Abstract: A cryogenically cooled radiation shield device as well as an associated method are provided in order to shield an area, such as a space vehicle capsule, from radiation. The radiation shield device may have embedded cryogen storage. The radiation shield device may include inner and outer coil shells that extend about the area to be shielded. Each coil shell includes coils formed of a superconductive material and disposed within respective first conduits. The radiation shield device may also include a first storage tank configured to store a first cryogen liquid and disposed in fluid communication with the first conduits. The first storage tank is disposed between the inner and outer coil shells. The radiation shield device may further include a second conduit at least partially surrounding the inner and outer coil shells that is at least partially filled with a second cryogen liquid, different than the first cryogen liquid.

Abstract: A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided therein. The pedicle screw assembly also includes a tip portion including a body having a cutting edge and a shank extending from the body. The shank has an externally threaded region provided thereon that cooperates with the internally threaded region of the bore to permit movement of the tip portion relative to the body portion between extended and retracted positions.

Abstract: The present invention provides a system and method for an improved player tracking in a gaming environment. Certain embodiments include a plurality of radio frequency identification (RFID) readers for detecting a response signal from an RFID tag, an RFID tag generating a response signal including identification data in response to an interrogation signal transmitted by one of the plurality of RFID readers, and a location manager controlling transmission by the plurality of RFID readers according to at least one collision-avoidance scheme. The collision-avoidance scheme may include one or more of the following schemes: localized RFID reader managers coordinating electrical operation of the plurality of RFID readers, an active RFID reader transmitting the interrogation signal and a plurality of passive RFID readers listening for the response signal, an RFID reader multiplexed through a plurality of antennas, TDMA, CDMA, and/or quasi-random synchronization for the RFID readers, for example.

Abstract: A method and apparatus for transparently handling recurring correctable errors and uncorrectable errors in a mirrored memory system prevents costly system shutdowns for correctable memory errors or system failures from uncorrectable memory errors. When a high number of correctable errors are detected for a given memory location, a memory relocation mechanism in the hypervisor moves the data associated with the memory location to an alternate physical memory location transparently to the partition such that the partition has no knowledge that the physical memory actualizing the memory location has been changed. When a correctable error occurs, the memory relocation mechanism uses data from a partner mirrored memory block as a data source for the memory block with the uncorrectable error and then relocates the data to a newly allocated memory block to replace the memory block with the uncorrectable error.

Abstract: A technique for collecting and correlating locking data collects and correlates information on a plurality of programs waiting on or holding a plurality of resources in a multi-computer database system. The technique identifies a program executing on one computer of the multi-computer database system that is waiting on a resource. The technique also identifies a second program, executing on another computer, as the ultimate holder of the resource. An operator display screen displays information corresponding to the first program and the second program. The operator display screen may be switched between a multiline display format and a single line display format. The collection, identification, and display of the locking data is performed periodically, to allow the operator to discover locking problems and take a desired corrective action.

Abstract: Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.

Abstract: Pulse jet air cleaner systems components and methods are described. The features relate to air cleaner housings that include a cartridge receiving section. Features described relate to a possible two-stage construction, a pulse jet accumulator section, pulse jet equipment for cleaning a filter cartridge positioned within the air cleaner; evacuation valve arrangements for projection of dust from the air cleaners; and other example features. Methods of assembly and use are also provided.

Abstract: In a preferred method of formation embodiment, a metal foil or film is obtained or formed with micro-holes. The foil is anodized to form metal oxide. One or more self-patterned metal electrodes are automatically formed and buried in the metal oxide created by the anodization process. The electrodes form in a closed circumference around each microcavity in a plane(s) transverse to the microcavity axis, and can be electrically isolated or connected. Preferred embodiments provide inexpensive microplasma device electrode structures and a fabrication method for realizing microplasma arrays that are lightweight and scalable to large areas. Electrodes buried in metal oxide and complex patterns of electrodes can also be formed without reference to microplasma devices—that is, for general electrical circuitry.

Abstract: Software program or application can determine if the storage device it was launched from is connected to the host computer system on an internal bus or an external bus. The ability of a software application to determine from where it and the operating system was launched allows it to perform a plurality of actions based on the launch location such as limiting the functionality of an application depending on its launch location. If a software company does not want its software to be installed or executed from an external drive or executed on multiple computers then it can limit the users ability to moved the software from one computer to another on a portable drive connected through a USB or IEEE-1394 port.

Abstract: The adhesion between a low surface energy (i.e., nonpolar) material, e.g., a polyolefin such as polyethylene, and a high surface energy (i.e., polar) material, e.g., a polyester, polyurethane, polycarbonate or polylactic acid, is promoted by blending with the nonpolar material typically from 15 to less than 50 wt % of a diol-based thermoplastic polyurethane (d-TPU), e.g., a polydiene diol-based TPU, based on the combined weight of the nonpolar material and the d-TPU. The promoted adhesion allows for the effective painting, printing, over-molding or HF-welding of a nonpolar substrate, e.g., a polyolefin film, with a polar coating, e.g., a paint, ink, etc. Aqueous dispersions can also be made from the blend of nonpolar material and d-TPU.

Abstract: A waterfowl decoy apparatus is disclosed for attracting a waterfowl. The waterfowl decoy apparatus comprises a blade having a generally sinusoidal cross-section for defining a first concave portion, a second concave portion and an inflection axis. A dark pigment is on a first side of the blade. A light pigment is on a second side of the blade. A first end of a hanger is secured to an object. A swivel couples a second end of the hanger to a top edge of the blade for rotating the blade relative to the hanger. The flow of air contacts the blade for rotating the blade. The dark pigment and the light pigment create an oscillating image upon rotating of the blade for attracting the waterfowl.

Abstract: Systems and methods of rolling and unrolling secondary flooring surfaces, such as tall pile turf, are provided. The system includes a core onto which the secondary flooring surface is rolled, the core being coupled on both ends to a frame that moves along a primary surface. The system includes a drive system that allows for the conversion of the primary surface into a secondary flooring surface in a relatively short period of time. The drive system includes core adjustable speed drive units for controlling the speed and torque of the motors that drive the core, as well as frame adjustable speed drive units for controlling the speed of the movement of the frames along the primary surface. The core adjustable speed drive units control the torque of the core motors during roll up and control the speed of the core motors during roll out.