Patents by Inventor Gary To

Gary To has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of &mgr;-amyloid peptide aggregation
    Patent number: 6610658
    Abstract: Compounds that modulate natural &bgr; amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a &bgr; amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a &bgr; amyloid peptide, preferably a retro-inverso isomer of A&bgr;17-21. In certain embodiments, the peptide is modified at the: amino-terminus, carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 26, 2003
    Assignee: Praecis Pharmaceuticals Inc.
    Inventors: Mark A. Findeis, Kathryn Phillips, Gary L. Olson, Christopher Self
  • Apparatus and method for feeding filler wire in a welding operation
    Patent number: 6610958
    Abstract: An apparatus (105) and method are provided for feeding wire (135) to a tip (120) of a torch (115) in a welding system (100). The apparatus (105) includes a drive mechanism (150) attached to the torch (115), and a guide assembly (155) attached to the drive mechanism. The guide assembly (155) includes a bracket (180) by which it is attached to the drive mechanism (150), a wire guide (185) through which the wire (135) is passed, and first and second adjustors (270A, 270B) to position the wire guide relative to the tip (120). The guide assembly (155) is configured to pass the wire (135) in a straight line from the drive mechanism (150) to the tip (120). In one embodiment, the adjustors (270A, 270B) include gimbals (275) supporting the wire guide (185). Each gimbal (275) is attached to a screw (280) passing through an opening in an arm (285) projecting from the bracket (180) of the guide assembly (155).
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: August 26, 2003
    Assignee: Precision Welding Technologies, Inc.
    Inventor: Gary A. Stricklen
  • Method and system for proofreading and correcting dictated text
    Patent number: 6611802
    Abstract: A method of proofreading and correcting dictated text contained in an electronic document comprises the steps of: selecting proofreading criteria for identifying textual errors contained in the electronic document; playing back each word contained in the electronic document; and, marking as a textual error each played back word in nonconformity with at least one of the proofreading criteria. The method can further comprise the step of editing each the marked textual error identified in the marking step. In particular, the editing step can include reviewing each the marked textual error identified in the marking step; accepting user specified changes to each marked textual error reviewed in the reviewing step; and, unmarking each marked textual error corrected by the user in the accepting step.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: August 26, 2003
    Assignee: International Business Machines Corporation
    Inventors: James R. Lewis, Barbara E. Ballard, Gary R. Hanson, Kerry A. Ortega, Ronald E. Vanbuskirk, Arthur Keller
  • Cloned genes encoding reverse transcriptase lacking RNase H activity
    Patent number: 6610522
    Abstract: The invention relates to a gene which encodes reverse transcriptase having DNA polymerase activity and substantially no RNase H activity. The invention also relates to vectors containing the gene and hosts transformed with the vectors of the invention. The invention also relates to a method of producing reverse transcriptase having DNA polymerase activity and substantially no RNase H activity by expressing the reverse transcriptase genes of the present invention in a host. The invention also relates to a method of producing cDNA from mRNA using the reverse transcriptase of the invention. The invention also relates to a kit for the preparation of cDNA from mRNA comprising the reverse transcriptase of the invention.
    Type: Grant
    Filed: December 24, 1998
    Date of Patent: August 26, 2003
    Assignee: Invitrogen Corporation
    Inventors: Michael Leslie Kotewicz, Gary Floyd Gerard
  • Article holding device for a cooler
    Patent number: 6609626
    Abstract: An article holding device for a cooler for removably positioning on a cooler for transportation items with the cooler. The article holding device for a cooler includes a top panel having a peripheral edge. A peripheral panel is attached to and extends along the peripheral edge such that a front panel, a back panel, and a pair of side panels are defined. The top panel is positionable on a cover of a cooler such that the peripheral panel generally covers walls of the cooler. A plurality of pockets is attached to the peripheral panel. Each of the pockets has an opening facing upwardly toward the top panel.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: August 26, 2003
    Inventors: Gary Young, Jim Young, Ray Young, Danny Young
  • Neurotherapeutic clavulanate composition and method
    Patent number: 6610681
    Abstract: Administration of clavulanic acid and related compounds at low dosages provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced cognition believed to be mediated by inhibition of neurogenic enzyme activity. Therapeutic methods for using such compounds and their pharmaceutical formulations are described.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: August 26, 2003
    Assignee: Revaax Pharmaceuticals, LLC
    Inventor: Gary A. Koppel
  • Selective call transceiver and method of re-registering same
    Patent number: 6611197
    Abstract: A method for re-establishing communication between a base station (102) that transmits on a forward channel, and a subscriber unit (108) that has temporarily lost the forward channel, uses the concept of a re-registration interval. The base station (102) transmits, to subscriber units (106, 108) in its area, a signal indicating the duration of a re-registration interval. A subscriber unit that has temporarily lost the forward channel determines whether the duration of such loss exceeds the re-registration interval. If the interval is exceeded, the subscriber unit sends a re-registration signal to the base station on a reverse channel. A selective call transceiver (400) is programmed to operate as a subscriber unit that uses the re-registration interval.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: August 26, 2003
    Assignee: Motorola, Inc.
    Inventors: Douglas I. Ayerst, Robert Gary Goodman, James A. Starkweather
  • Method and apparatus for generating consistent image registration
    Patent number: 6611615
    Abstract: The present invention provides a method and apparatus for generating inversely related forward and reverse image transformations in any image registration technique with ambiguous correspondence based upon the joint estimation of the transformation. Accordingly, two image data sets are received, a source and a target. Current sets of forward and reverse displacement fields are initialized. From the current set of forward and reverse displacement fields, the consistent forward transformation and the consistent reverse transformation are jointly estimated. These transformations are outputted.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: August 26, 2003
    Assignee: University of Iowa Research Foundation
    Inventor: Gary E. Christensen
  • Method and system for estimating gas production by a landfill or other subsurface source
    Patent number: 6611760
    Abstract: A new and useful method and system for estimating LFG generation and gas permeability in a landfill or other subsurface-gas producing body of material is provided. The gas generation rate in a portion of a landfill or other subsurface-gas producing body of material is estimated by obtaining a time history record of atmospheric pressure that is representative of atmospheric pressure at a surface boundary of the portion of the landfill or the subsurface gas producing body of material, measuring the gas pressure at least at one selected location at the landfill (or subsurface body of material) site over a time period that is included in the time history record, and using the atmospheric pressure and the measured gas pressure over the time period to estimate LFG generation rate and gas permeability of the portion of the landfill or the subsurface gas producing body of material.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: August 26, 2003
    Assignee: Hydro Geo Chem, Inc.
    Inventors: Harold W. Bentley, Gary R. Walter, Stewart J. Smith, Jinshan Tang, Christian T. Williamson
  • Adeno associated virus vectors for the treatment of a cardiomyopathy
    Patent number: 6610290
    Abstract: The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: August 26, 2003
    Assignees: Avigen, Inc., Johns Hopkins University
    Inventors: Gregory M. Podsakoff, Paul D. Kessler, Barry J. Byrne, Gary J. Kurtzman
  • Recombinational cloning using nucleic acids having recombination sites
    Publication number: 20030157716
    Abstract: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).
    Type: Application
    Filed: November 2, 2001
    Publication date: August 21, 2003
    Inventors: James L. Hartley, Michael A. Brasch, Gary F. Temple, Donna K. Fox
  • New compounds
    Publication number: 20030158202
    Abstract: The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
    Type: Application
    Filed: June 11, 2002
    Publication date: August 21, 2003
    Inventors: Patrizia Caldirola, Gary Johansson, Andrew Mott, Katarina Beierlien, Markus Thor, Lars Tedenborg, Ulf Bremberg, Annika Jenmalm Jensen
  • Neurotherapeutic composition and method therefor
    Publication number: 20030158172
    Abstract: Neurotherapeutically pharmaceutical effective compositions are prepared using carboxypeptidase E inhibitors. One class of carboxypeptidase E inhibitors found to exhibit significant neurotropic activity are &bgr;-lactam compounds, particularly penam and cephem &bgr;-lactam antibiotics and non-antibiotic derivatives thereof.
    Type: Application
    Filed: August 20, 2002
    Publication date: August 21, 2003
    Inventors: Gary A. Koppel, Michael O. Chaney
  • Anti-microbial utility and kitchen wipe utilizing metallic silver as an oligodynamic agent
    Publication number: 20030157147
    Abstract: A long-lasting antimicrobial wipe using metallic silver as the oligodynamic agent. The wipe has an outer layer of a flexible textile fabric having metallic silver deposited thereon, bonded to an inner layer of a fibrous water-retaining material. The silver is preferably deposited on the textile fabric by electroless coating, to provide efficient coverage of all available surfaces.
    Type: Application
    Filed: February 15, 2002
    Publication date: August 21, 2003
    Inventors: William Hoge, Gary Winch, David Yearsley
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Publication number: 20030157089
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Application
    Filed: May 9, 2002
    Publication date: August 21, 2003
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Robert A. Henderson, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A.W. Skeiky, William T. Hepler, John Hural, Patricia D. McNeill, Raymond L. Houghton, Carlota Vinals y de Bassols, Teresa M. Foy, Yoshihiro Watanabe, Madeleine Joy Meagher, Ta Deng
  • Antigen arrays for treatment of allergic eosinophilic diseases
    Publication number: 20030157479
    Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses.
    Type: Application
    Filed: November 7, 2002
    Publication date: August 21, 2003
    Inventors: Martin Bachmann, Gary Jennings, Ivo Sonderegger
  • ULTRASOUND ASSEMBLY FOR USE WITH LIGHT ACTIVATED DRUGS
    Publication number: 20030157024
    Abstract: A kit and method for causing tissue death within a tissue site is disclosed. The kit includes a media with a light activated drug activatable upon exposure to a particular level of ultrasound energy. The kit also includes a catheter with a lumen coupled with a media delivery port through which the light activated drug can be locally delivered to the tissue site. The ultrasound transducer is configured to transmit the level of ultrasound energy which activates the light activated drug with sufficient power that the ultrasound energy can penetrate the tissue site.
    Type: Application
    Filed: November 26, 2002
    Publication date: August 21, 2003
    Inventors: Katsuro Tachibana, Shunro Tachibana, James R. Anderson, Gary Lichttenegger
  • Molecular torches
    Publication number: 20030157542
    Abstract: The present invention features “molecular torches” and the use of molecular torches for detecting the presence of a target nucleic acid sequence. Molecular torches contain a target binding domain, a target closing domain, and a joining region. The target binding domain is biased towards the target sequence such that the target binding domain forms a more stable hybrid with the target sequence than with the target closing domain under the same hybridization conditions. The joining region facilitates the formation or maintenance of a closed torch.
    Type: Application
    Filed: January 27, 2003
    Publication date: August 21, 2003
    Inventors: Michael M. Becker, Gary P. Schroth
  • Measurement marking, scribing and scoring device
    Publication number: 20030154615
    Abstract: A measurement marking and scoring device includes a platform configured to be affixed to a base of a tape measure. A marking member extends from the platform and defines a sharpened edge or point marking surface at a lower end thereof. An alignment tab extends from the marking member so as to be positioned over indicia of a tape extended from the tape measure so that measurement marks or score lines can be created on a working surface upon application of pressure to the marking member or tape measure. In another form, the device is integrally formed into a tape measure such that the marking member extends from a front edge of the tape measure.
    Type: Application
    Filed: December 17, 2002
    Publication date: August 21, 2003
    Inventor: Gary Landon Worthington
  • Cargo restraining device
    Patent number: D478857
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: August 26, 2003
    Assignee: Logistick, Inc.
    Inventors: Donald H. Petersen, John W. Doster, Gary Zachrich, John Townsend