Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: A service tag is generated and stored on a computer when a make-to-order computer is assembled. When a user receives a computer and attempts to access the internet, a unique number, the service tag, is provided by the computer to an internet service provider's (ISP's) host server. The host server provides the key to a proprietary server, such as a server operated by the manufacturer of the computer. The proprietary server compares the service tag number received from the ISP server to a list of valid service tag numbers. If the service tag number is valid the proprietary server returns a purchase plan to the ISP server, allowing the user to obtain previously agreed benefits. One embodiment provides internet access as the previously agreed benefits.