Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: A resistance assembly for a hydraulic resistance exercise apparatus includes a single-action hydraulic cylinder having a longitudinal axis and extending from a first end to a second end. The single-action cylinder provides resistance to compression of the cylinder, one end toward the other, but provides little or no resistance to extension of the cylinder, one end away from the other. A first compression linkage compresses the hydraulic cylinder in response to movement of a first exercise resistance lever in a first direction. A second compression linkage compresses the hydraulic cylinder in response to movement of a second exercise resistance lever in a second direction directly opposed to the first direction. An engagement exercise lever includes an engagement pin for selectively engaging the engagement exercise lever to move in fixed relation to one or the other the first or second exercise levers in both the first and second direction.

Abstract: An exercise apparatus (10) includes a hydraulic resistance member (50) with a single sided hydraulic cylinder (53) for pumping fluid through a fluid circuit (80). Lever members (31, 32) pivot in a common plane and extend outward to embrace the hydraulic resistance member (50) between them. Stop members (221,223) limit movement of the lever members (31, 32), and biasing member (230) biases 10 the lever members (31,32) apart. An immobilizing member (40) may selectively immobilize either one of the lever members (31, 32). An extension arm (17) supports an exercise member (16) which may move along an exercise stroke only by pumping cylinder (53). The fluid circuit (80) allows fluid to flow from the cylinder (53) only when pressure in the cylinder (53) exceeds a selected pressure corresponding to a selected exercising force determined in accordance with the position of the member (16) along the exercise stroke by a control linkage (100). During the return stroke, no exercising force is required.

Abstract: A hydraulic exercise apparatus includes a hydraulic pump for pumping fluid through a fluid circuit in response to movement of an exercise member along an exercise stroke in such a manner that the force required to move the exercise member is dependent upon the pressure of fluid pumped. The fluid circuit includes valve means for allowing fluid to flow through the circuit only when a fluid pressure exceeds a selected pressure. The hydraulic exercise apparatus further includes pressure selection means for determining the selected pressure in accordance with the position of the exercise member along the exercise stroke.

Abstract: A support leg for trailer tongues which comprises an L-shaped ground support leg having a horizontal portion of square cross-section, a leg mounting bracket having a hollow cylindrical interior capped at one end and open at the other end with a circular cross-section of sufficient diameter to telescopically and rotatively receive the horizontal leg portion and terminating at its closed end in an internal leg-locking cavity of square cross-section, said internal cavity being adapted to telescoping receive said horizontal leg portion and restrain said horizontal leg portion against rotative movement, whereby said horizontal leg portion may be withdrawn from said internal leg locking cavity and rotate in said hollow cylindrical interior from a retracted to an extended position and vice versa and then telescopically inserted back into the internal cavity for locking engagement in the new position, a tension spring to resist telescoping disengagement of said leg horizontal portion from the internal leg locking cav