Abstract: The present invention relates to the ATR kinase inhibitor, 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine, for use in the treatment of a hyper-proliferative disease, characterized in that it is administered in an amount of from 10 mg to 160 mg per day, particularly in an amount of 60 to 160 mg per day. The present invention also relates to a pharmaceutical composition comprising 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine in an amount of from 5 mg to 80 mg and at least one pharmaceutically acceptable excipient. The present invention also relates to a process for manufacturing said pharmaceutical composition.

Abstract: Provided is a wood splitter having a support element, a first elongated element, a second elongated element, and wood splitting components. A support element may be a first elongated element and a second elongated element engaged to the first elongated element. The first elongated element may be subject to a first pre-stress load. The first pre-stress load may be a first moment. The a second elongated element may be engaged to the first elongated element and may be subject to a second pre-stress load. Wood splitting components may be engaged with at least one of a first elongated element or a second elongated element, may be adapted to operate to split wood, and may be adapted to apply an operational load during operation to the first elongated element. The operational load may at least partially relax the first moment.

Abstract: Provided is a wood splitter comprising a support element, a first elongated element, a second elongated element, and wood splitting components. A support element may comprise a first elongated element and a second elongated element engaged to said first elongated element. The a first elongated element may be subject to a first pre-stress load. The first pre-stress load may comprise a first moment. The a second elongated element may be engaged to the first elongated element and may be subject to a second pre-stress load. Wood splitting components may be engaged with at least one of a first elongated element or a second elongated element, may be adapted to operate to split wood, and may be adapted to apply an operational load during operation to the first elongated element. The operational load may at least partially relax the first moment.