Abstract: The present invention provides a simple, inexpensive apparatus for and method of capturing biological or other material from sample suspensions on a collection surface and for depositing captured material on a receiving surface, such as a microscope slide, for observation and analysis. Accordingly, cytological material may be deposited in near mono-layers for the detection of disease. In one embodiment of the present invention, density gradients of material are captured and deposited, thus providing a desired range of concentrations for examination. In another embodiment multiple depositions or multiple slides may be made from the same sample suspension. The method and apparatus to exploit this new method are both presented for various applications. The dimensions of material captured and deposited may be controlled and used in conjunction with microscope slides that confine material to specific regions of interest.

Abstract: The present invention is a method of identifying and assessing DNA euchromatin in biological cells. The amount and/or distribution of DNA euchromatin generally relates to RNA/protein synthesis, which may change in certain conditions, such as disease, and/or cellular response to environmental and/or chemical agents. The present invention detects the potential presence of disease by assessing DNA euchromatin in ostensibly normal cells and similarly provides means to monitor and assess treatment response. The present invention may also be used to assess how application (or removal) of influences, such as environment, radiation, chemical agents, medications, herbs, vitamins, etc., interact to effect cells, establishing uses in monitoring wellness and pharmacological screening. Additional uses include assessing age related disorders, allergies, infections, Alzheimer's disease, ‘Time of Death’, chronic fatigue syndrome, etc.

Abstract: A syringe device incorporating ridges that cause resistive changes to the movement of the syringe gasket or plunger, thereby providing user feedback as to the position and speed of plunger movement. Such user feedback may be useful in stressful situations, under poor lighting conditions or in other unfavorable circumstances. Additionally, in certain embodiments these ridges may aid in accurate dispension or allow the syringe to derive additional functionality, such as performing as a vacuum source. Ridges can be protrusions such as tabs, bubbles or continuous rings for single or repeated use or these ridges may be formed as indentations. Ridges may be formed in patterns, in various sizes and shapes or these ridges may be mixed and matched as required or desired. Ridges may also be formed from a soluble material and the resistive change may itself provide indication that the material has been substantially dissolved and dispensed.

Abstract: The present invention is a filter apparatus with methods to capture a desired amount of material suspended in a liquid or gas for monolayer deposition, analysis or other uses. Novel filter devices are employed to capture material which may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs sensors to sense pressure and adjust, halt or otherwise control sample flow. The pressure sensor essentially monitors the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. A separate valve or valve integrated with pressure sensing provides a means to adjust sample flow.

Abstract: The present invention is a disc media storage and retrieval system for safely and efficiently storing and conveniently retrieving specific disc media from a plurality of disc media stacked on a central column or spindle. Modified disc media are rotationally aligned on the spindle using corresponding alignment protrusion(s) formed on the spindle and notch(es) on the inner chuck hole of the disc. Accordingly, disc media is further modified with the addition of indexing notches on the outer circumference of the disk, such that each disc within the system is provided a unique notched-index. The aligned stack is protected by a cover member that forms a disc lifting device. A disc of interest is indexed and retrieved from the stack by rotating the cover member relative to the disc stack thereby aligning the disc notch-index with the lifting device. When the cover member is raised, the lifting device separates the stack at the disc of interest.

Abstract: The present invention is a disc media storage and retrieval system for safely and efficiently storing and conveniently retrieving specific disc media from a plurality of disc media stacked on a central column or spindle. Modified disc media are rotationally aligned on the spindle using corresponding alignment protrusion(s) formed on the spindle and notch(es) on the inner chuck hole of the disc. Accordingly, disc media is further modified with the addition of indexing notches on the outer circumference of the disk, such that each disc within the system is provided a unique notched-index. The aligned stack is protected by a cover member that forms a disc lifting device. A disc of interest is indexed and retrieved from the stack by rotating the cover member relative to the disc stack thereby aligning the disc notch-index with the lifting device. When the cover member is raised, the lifting device separates the stack at the disc of interest.

Abstract: The present invention is a method of identifying and assessing DNA euchromatin in biological cells. The amount and/or distribution of DNA euchromatin generally relates to RNA/protein synthesis, which may change in certain conditions, such as disease, and/or cellular response to environmental and/or chemical agents. The present invention detects the potential presence of disease by assessing DNA euchromatin in ostensibly normal cells and similarly provides means to monitor and assess treatment response. The present invention may also be used to assess how application (or removal) of influences, such as environment, radiation, chemical agents, medications, herbs, vitamins, etc., interact to effect cells, establishing uses in monitoring wellness and pharmacological screening. Additional uses include assessing age related disorders, allergies, infections, Alzheimer's disease, ‘Time of Death’, chronic fatigue syndrome, etc.

Abstract: The present invention is a filter apparatus with methods to capture a desired amount of material suspended in a liquid or gas for monolayer deposition, analysis or other uses. Novel filter devices are employed to capture material which may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs means to sense pressure and adjust, halt or otherwise control sample flow. The pressure sensor essentially monitors the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. A separate valve or valve integrated with pressure sensing provides a means to adjust sample flow.

Abstract: The present invention is a filter device with methods to capture a desired amount of material suspended in a liquid or gas. These filter capture methods may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs means to sense pressure and thereby respond to pressure changes associated with the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. Additionally, the filter device employs a means to halt or otherwise adjust sample flow when such a predetermined pressure is sensed.

Abstract: A syringe device incorporating ridges that cause resistive changes to the movement of the syringe gasket or plunger, thereby providing user feedback as to the position and speed of plunger movement. Such user feedback may be useful in stressful situations, under poor lighting conditions or in other unfavorable circumstances. Additionally, in certain embodiments these ridges may aid in accurate dispension or allow the syringe to derive additional functionality, such as performing as a vacuum source. Ridges can be protrusions such as tabs, bubbles or continuous rings for single or repeated use or these ridges may be formed as indentations. Ridges may be formed in patterns, in various sizes and shapes or these ridges may be mixed and matched as required or desired. Ridges may also be formed from a soluble material and the resistive change may itself provide indication that the material has been substantially dissolved and dispensed.

Abstract: The present invention provides a simple, inexpensive apparatus for and method of capturing biological or other material from sample suspensions on a collection surface and for depositing captured material on a receiving surface, such as a microscope slide, for observation and analysis. Accordingly, cytological material may be deposited in near mono-layers for the detection of disease. In one embodiment of the present invention, density gradients of material are captured and deposited, thus providing a desired range of concentrations for examination. In another embodiment multiple depositions or multiple slides may be made from the same sample suspension. The method and apparatus to exploit this new method are both presented for various applications. The dimensions of material captured and deposited may be controlled and used in conjunction with microscope slides that confine material to specific regions of interest.

Abstract: The present invention is a non-coherent optical fiber apparatus that may be used for imaging. Methods are described to produce geometric mapping data for an optical fiber apparatus. Images may be transmitted, reconstructed (using mapping data for the apparatus) and displayed. In addition, one or more fiber characteristics may be measured and used in conjunction with mapping data to further improve or correct the geometric, photometric or spectral content of images. The apparatus data described may be provided, by a manufacturer, for example, in raw form, or this data may be may be provided in a manner that is more user transparent, such as incorporating it into various image processing algorithms.

Abstract: A deterrent device comprises a portable container having a cavity disposed therein and an actuator mechanism disposed within the cavity. An inflatable deterrent extends outwardly from the actuator mechanism, the inflatable deterrent is substantially contained within the cavity in a non-operative configuration. The actuator mechanism is activated by an operator to attain an operative configuration in which the actuator mechanism inflates the inflatable deterrent outwardly from the container, an assailant being deterred by the inflated inflatable deterrent.