Patents by Inventor Gary Zabow

Gary Zabow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190262478
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Application
    Filed: March 4, 2019
    Publication date: August 29, 2019
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Patent number: 10350312
    Abstract: The present invention relates to magnetic contrast structures for magnetic resonance imaging, and methods of their use. The contrast structures include magnetic materials arranged as a pair of disk-shaped magnetic components with a space between a circular surface of each disk shape, or a tubular magnetic structure, a substantially cylindrical magnetic structure, a substantially spherical shell-formed magnetic structure, or a substantially ellipsoidal shell-formed structure, each defining a hollow region therein. The space and/or hollow region in the contrast structure creates a spatially extended region contained within a near-field region of the contrast structure over which an applied magnetic field results in a homogeneous field, such that nuclear magnetic moments of a second material when arranged within the spatially extended region precess at a characteristic Larmor frequency, whereby the contrast structure is adapted to emit a characteristic magnetic resonance signal of the magnetic material.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: July 16, 2019
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Sectretary of Commerce
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Patent number: 10220103
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: March 5, 2019
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Secretary of Commerce
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Patent number: 10215825
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents. The invention also relates to a magnetic resonance sensor that alters it shape in response to a condition of an environment such that the condition may be detected.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: February 26, 2019
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Secretary of Commerce
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John M Moreland
  • Patent number: 10188755
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 29, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Secretary of Commerce
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Publication number: 20150377997
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents. The invention also relates to a magnetic resonance sensor that alters it shape in response to a condition of an environment such that the condition may be detected.
    Type: Application
    Filed: March 16, 2015
    Publication date: December 31, 2015
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John M. Moreland
  • Publication number: 20150367001
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 24, 2015
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Publication number: 20150369895
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 24, 2015
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Publication number: 20150367002
    Abstract: The present invention relates to magnetic contrast structures for magnetic resonance imaging, and methods of their use. The contrast structures include magnetic materials arranged as a pair of disk-shaped magnetic components with a space between a circular surface of each disk shape, or a tubular magnetic structure, a substantially cylindrical magnetic structure, a substantially spherical shell-formed magnetic structure, or a substantially ellipsoidal shell-formed structure, each defining a hollow region therein. The space and/or hollow region in the contrast structure creates a spatially extended region contained within a near-field region of the contrast structure over which an applied magnetic field results in a homogeneous field, such that nuclear magnetic moments of a second material when arranged within said spatially extended region precess at a characteristic Larmor frequency, whereby the contrast structure is adapted to emit a characteristic magnetic resonance signal of the magnetic material.
    Type: Application
    Filed: June 12, 2015
    Publication date: December 24, 2015
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Patent number: 9084819
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: July 21, 2015
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health, THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Gary Zabow, Stephen Dodd, Alan Korelsky, John M. Moreland
  • Patent number: 9084820
    Abstract: A magnetic resonance contrast agent has a medium, and a contrast structure dispersed in the medium. The contrast structure comprises a magnetic material arranged to create a local region of a local magnetic field such that nuclear magnetic moments of a material when arranged within the local region precess at a characteristic Larmor frequency about a total magnetic field in the local region while in use, the characteristic Larmor frequency being identifiable with the contrast structure, and the total magnetic field in the local region being a substantially spatially uniform magnetic field.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: July 21, 2015
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health, The United States of America, Represented by the Secretary of Commerce
    Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
  • Publication number: 20110144478
    Abstract: A magnetic resonance contrast agent has a medium, and a contrast structure dispersed in the medium. The contrast structure comprises a magnetic material arranged to create a local region of a local magnetic field such that nuclear magnetic moments of a material when arranged within said local region precess at a characteristic Larmor frequency about a total magnetic field in the local region while in use, the characteristic Larmor frequency being identifiable with the contrast structure, and the total magnetic field in the local region being a substantially spatially uniform magnetic field.
    Type: Application
    Filed: April 20, 2009
    Publication date: June 16, 2011
    Inventors: Gary Zabow, Stephen Dodd, Alan Konstsky, John Moreland
  • Publication number: 20110014129
    Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.
    Type: Application
    Filed: April 2, 2010
    Publication date: January 20, 2011
    Inventors: Gary Zabow, Stephen Dodd, Alan Korelsky, John M. Moreland
  • Publication number: 20020166800
    Abstract: The invention provides systems and methods of manipulating biological or chemical species. The species may be attached to a magnetic particle which is manipulated using micro-magnetic fields. In some cases, the magnetic fields are generated by current carrying wires that are patterned on a substrate. The magnetic fields define channels on the surface of the substrate in which the magnetic particles and attached species may be transported, positioned and stored. Thus, the systems and methods can manipulate biological or chemical species on a microscale (e.g., less than 5 cm). Applications of the systems and methods are in, but are not limited to, the fields of biotechnology, microanalysis, and microsynthesis.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 14, 2002
    Inventors: Mara G. Prentiss, Gary Zabow, Tao Deng, Mala Lakshmi Radhakrishnan, George M. Whitesides
  • Publication number: 20020166760
    Abstract: The invention provides systems and methods of manipulating biological or chemical species. The species may be attached to a magnetic particle which is manipulated using micro-magnetic fields. In some cases, the magnetic fields are generated by current carrying wires that are patterned on a substrate. The magnetic fields define channels on the surface of the substrate in which the magnetic particles and attached species may be transported, positioned and stored. In other cases, the magnetic fields are generated by magnetic features located within the channels on the surface of the substrate. Thus, the systems and methods can manipulate biological or chemical species on a microscale (e.g., less than 5 cm). Applications of the systems and methods are in, but are not limited to, the fields of biotechnology, microanalysis, and microsynthesis.
    Type: Application
    Filed: November 30, 2001
    Publication date: November 14, 2002
    Inventors: Mara G. Prentiss, Gary Zabow, Tao Deng, Mala Lakshmi Radhakrishnan, George M. Whitesides
  • Publication number: 20020001855
    Abstract: The invention relates to a new method for conducting parallel manipulations of biological entities with emphasis on measurements of binding strengths between, or elastic strengths of, various biological molecules. In particular, the invention involves the generation and use of high magnetic fields and in particular high magnetic field gradients over extended areas using electromagnetic or permanent magnets in one- or two-dimensional grids, which can be used to measure simultaneously multiple binding interactions. The binding interactions may all be the same or may each be different from the others.
    Type: Application
    Filed: March 22, 2001
    Publication date: January 3, 2002
    Inventors: Mara G. Prentiss, Gary Zabow