Patents by Inventor Gary Zabow
Gary Zabow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11745493Abstract: A process for making an ultra-conformal microprint by ultra-conformal microprint transferring includes: disposing a transfer moiety arranged in a microstructure on a transfer substrate; disposing a glassy transfer layer on the transfer moiety; forming a glassy composite; removing the glassy composite from the transfer substrate while maintaining the microstructure of the transfer moiety in the glassy transfer layer; disposing the glassy composite on a microprint substrate; ultra-conformally covering the microprint substrate with the glassy composite by heating the glassy composite so that it flows while maintaining the microstructure of the transfer moiety in the glassy transfer layer so that the microstructure is disposed on the microprint substrate; and removing the glassy transfer layer while leaving the transfer moiety disposed in the microstructure on the microprint substrate to form the ultra-conformal microprint including the transfer moiety arranged in the microstructure on the microprint substrate.Type: GrantFiled: August 7, 2020Date of Patent: September 5, 2023Assignee: GOVERNMENT OF THE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCEInventor: Gary Zabow
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Patent number: 11324840Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: GrantFiled: March 4, 2019Date of Patent: May 10, 2022Assignees: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES, THE USA, AS REPRESENTED BY THE SECRETARY OF COMMERCEInventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Publication number: 20220040970Abstract: A process for making an ultra-conformal microprint by ultra-conformal microprint transferring includes: disposing a transfer moiety arranged in a microstructure on a transfer substrate; disposing a glassy transfer layer on the transfer moiety; forming a glassy composite; removing the glassy composite from the transfer substrate while maintaining the microstructure of the transfer moiety in the glassy transfer layer; disposing the glassy composite on a microprint substrate; ultra-conformally covering the microprint substrate with the glassy composite by heating the glassy composite so that it flows while maintaining the microstructure of the transfer moiety in the glassy transfer layer so that the microstructure is disposed on the microprint substrate; and removing the glassy transfer layer while leaving the transfer moiety disposed in the microstructure on the microprint substrate to form the ultra-conformal microprint including the transfer moiety arranged in the microstructure on the microprint substrate.Type: ApplicationFiled: August 7, 2020Publication date: February 10, 2022Inventor: Gary Zabow
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Publication number: 20190262478Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: ApplicationFiled: March 4, 2019Publication date: August 29, 2019Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Patent number: 10350312Abstract: The present invention relates to magnetic contrast structures for magnetic resonance imaging, and methods of their use. The contrast structures include magnetic materials arranged as a pair of disk-shaped magnetic components with a space between a circular surface of each disk shape, or a tubular magnetic structure, a substantially cylindrical magnetic structure, a substantially spherical shell-formed magnetic structure, or a substantially ellipsoidal shell-formed structure, each defining a hollow region therein. The space and/or hollow region in the contrast structure creates a spatially extended region contained within a near-field region of the contrast structure over which an applied magnetic field results in a homogeneous field, such that nuclear magnetic moments of a second material when arranged within the spatially extended region precess at a characteristic Larmor frequency, whereby the contrast structure is adapted to emit a characteristic magnetic resonance signal of the magnetic material.Type: GrantFiled: June 12, 2015Date of Patent: July 16, 2019Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Sectretary of CommerceInventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Patent number: 10220103Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: GrantFiled: June 15, 2015Date of Patent: March 5, 2019Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Secretary of CommerceInventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Patent number: 10215825Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents. The invention also relates to a magnetic resonance sensor that alters it shape in response to a condition of an environment such that the condition may be detected.Type: GrantFiled: March 16, 2015Date of Patent: February 26, 2019Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Secretary of CommerceInventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John M Moreland
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Patent number: 10188755Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: GrantFiled: June 15, 2015Date of Patent: January 29, 2019Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The United States of America, as represented by the Secretary of CommerceInventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Publication number: 20150377997Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents. The invention also relates to a magnetic resonance sensor that alters it shape in response to a condition of an environment such that the condition may be detected.Type: ApplicationFiled: March 16, 2015Publication date: December 31, 2015Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John M. Moreland
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Publication number: 20150369895Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: ApplicationFiled: June 15, 2015Publication date: December 24, 2015Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Publication number: 20150367001Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: ApplicationFiled: June 15, 2015Publication date: December 24, 2015Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Publication number: 20150367002Abstract: The present invention relates to magnetic contrast structures for magnetic resonance imaging, and methods of their use. The contrast structures include magnetic materials arranged as a pair of disk-shaped magnetic components with a space between a circular surface of each disk shape, or a tubular magnetic structure, a substantially cylindrical magnetic structure, a substantially spherical shell-formed magnetic structure, or a substantially ellipsoidal shell-formed structure, each defining a hollow region therein. The space and/or hollow region in the contrast structure creates a spatially extended region contained within a near-field region of the contrast structure over which an applied magnetic field results in a homogeneous field, such that nuclear magnetic moments of a second material when arranged within said spatially extended region precess at a characteristic Larmor frequency, whereby the contrast structure is adapted to emit a characteristic magnetic resonance signal of the magnetic material.Type: ApplicationFiled: June 12, 2015Publication date: December 24, 2015Inventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Patent number: 9084820Abstract: A magnetic resonance contrast agent has a medium, and a contrast structure dispersed in the medium. The contrast structure comprises a magnetic material arranged to create a local region of a local magnetic field such that nuclear magnetic moments of a material when arranged within the local region precess at a characteristic Larmor frequency about a total magnetic field in the local region while in use, the characteristic Larmor frequency being identifiable with the contrast structure, and the total magnetic field in the local region being a substantially spatially uniform magnetic field.Type: GrantFiled: April 20, 2009Date of Patent: July 21, 2015Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health, The United States of America, Represented by the Secretary of CommerceInventors: Gary Zabow, Stephen Dodd, Alan Koretsky, John Moreland
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Patent number: 9084819Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: GrantFiled: April 2, 2010Date of Patent: July 21, 2015Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health, THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF COMMERCEInventors: Gary Zabow, Stephen Dodd, Alan Korelsky, John M. Moreland
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Publication number: 20110144478Abstract: A magnetic resonance contrast agent has a medium, and a contrast structure dispersed in the medium. The contrast structure comprises a magnetic material arranged to create a local region of a local magnetic field such that nuclear magnetic moments of a material when arranged within said local region precess at a characteristic Larmor frequency about a total magnetic field in the local region while in use, the characteristic Larmor frequency being identifiable with the contrast structure, and the total magnetic field in the local region being a substantially spatially uniform magnetic field.Type: ApplicationFiled: April 20, 2009Publication date: June 16, 2011Inventors: Gary Zabow, Stephen Dodd, Alan Konstsky, John Moreland
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Publication number: 20110014129Abstract: The present invention relates to a magnetic resonance structure with a cavity or a reserved space that provides contrast and the additional ability to frequency-shift the spectral signature of the NMR-susceptible nuclei such as water protons by a discrete and controllable characteristic frequency shift that is unique to each MRS design. The invention also relates to nearly uniform solid magnetic resonance T2* contrast agents that have a significantly higher magnetic moment compared to similarly-sized existing MRI contrast agents.Type: ApplicationFiled: April 2, 2010Publication date: January 20, 2011Inventors: Gary Zabow, Stephen Dodd, Alan Korelsky, John M. Moreland
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Publication number: 20020166800Abstract: The invention provides systems and methods of manipulating biological or chemical species. The species may be attached to a magnetic particle which is manipulated using micro-magnetic fields. In some cases, the magnetic fields are generated by current carrying wires that are patterned on a substrate. The magnetic fields define channels on the surface of the substrate in which the magnetic particles and attached species may be transported, positioned and stored. Thus, the systems and methods can manipulate biological or chemical species on a microscale (e.g., less than 5 cm). Applications of the systems and methods are in, but are not limited to, the fields of biotechnology, microanalysis, and microsynthesis.Type: ApplicationFiled: May 11, 2001Publication date: November 14, 2002Inventors: Mara G. Prentiss, Gary Zabow, Tao Deng, Mala Lakshmi Radhakrishnan, George M. Whitesides
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Publication number: 20020166760Abstract: The invention provides systems and methods of manipulating biological or chemical species. The species may be attached to a magnetic particle which is manipulated using micro-magnetic fields. In some cases, the magnetic fields are generated by current carrying wires that are patterned on a substrate. The magnetic fields define channels on the surface of the substrate in which the magnetic particles and attached species may be transported, positioned and stored. In other cases, the magnetic fields are generated by magnetic features located within the channels on the surface of the substrate. Thus, the systems and methods can manipulate biological or chemical species on a microscale (e.g., less than 5 cm). Applications of the systems and methods are in, but are not limited to, the fields of biotechnology, microanalysis, and microsynthesis.Type: ApplicationFiled: November 30, 2001Publication date: November 14, 2002Inventors: Mara G. Prentiss, Gary Zabow, Tao Deng, Mala Lakshmi Radhakrishnan, George M. Whitesides
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Publication number: 20020001855Abstract: The invention relates to a new method for conducting parallel manipulations of biological entities with emphasis on measurements of binding strengths between, or elastic strengths of, various biological molecules. In particular, the invention involves the generation and use of high magnetic fields and in particular high magnetic field gradients over extended areas using electromagnetic or permanent magnets in one- or two-dimensional grids, which can be used to measure simultaneously multiple binding interactions. The binding interactions may all be the same or may each be different from the others.Type: ApplicationFiled: March 22, 2001Publication date: January 3, 2002Inventors: Mara G. Prentiss, Gary Zabow