Patents by Inventor Gatis Plume

Gatis Plume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of heterocyclic alkylamide derivatives
    Patent number: 5432284
    Abstract: The present invention relates to a novel process for the preparation of heterocyclic alkylamide derivatives having the following formula: ##STR1## and the pharmaceutically acceptable acid addition salt thereof wherein X represents halo, alkyl having 1 to 6 carbon atoms, hydrido, trifluoromethyl, phenyl, or lower alkoxy having 1 to 6 carbon atoms; Y represents the group --CN or --CONH.sub.2 ; R.sub.2 represents alkyl having 1 to 6 carbon atoms; R.sub.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: July 11, 1995
    Assignee: G. D. Searle & Co.
    Inventors: John H. Dygos, Thomas R. Kowar, Kathleen T. McLaughlin, Gatis Plume, Michael L. Prunier, Richard J. Salzmann, Mike G. Scaros, Joseph J. Wieczorek
  • Process for the resolution of (.+-.)-.alpha.-[2-[acetyl(1-methylethyl)amino]ethyl]-.alpha.-(2-chloroph enyl)-1-piperidinebutanamide
    Patent number: 5276155
    Abstract: A process for the resolution of (.+-.)-.alpha.-[2-[acetyl(1-methylethyl)amino]ethyl-.alpha.-(2-chloropheny l)-1-piperidinebutanamide having the following structure ##STR1## into its (+) and (-) enantiomers using camphorsulfonic acid.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: January 4, 1994
    Assignee: G. D. Searle & Co.
    Inventors: John R. Medich, Gatis Plume