Patents by Inventor Gaudenz Danuser
Gaudenz Danuser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220351530Abstract: A system and method of screening biological specimens by at least one processor may include receiving a sample image depicting a biological specimen; applying a machine-learning (ML) based autoencoder on the sample image, wherein said autoencoder is trained to generate a reconstructed version of the sample image, via a latent feature vector; associating a latent feature of the latent feature vector to a corresponding visual phenotype of the biological specimen; and screening the biological specimen based on said association. Embodiments of the invention may subsequently modify a value of the latent feature to produce a vector set, comprising a plurality of latent feature vectors; apply a decoder portion of the autoencoder on the vector set, to produce a corresponding reconstructed image set, representing evolution or amplification of a visual phenotype of the biological specimen; and associate the latent feature to the visual phenotype based on the reconstructed image set.Type: ApplicationFiled: May 3, 2022Publication date: November 3, 2022Inventors: Assaf ZARITSKY, Gaudenz DANUSER, Andrew R. JAMIESON
-
Patent number: 9933363Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.Type: GrantFiled: August 18, 2014Date of Patent: April 3, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Gaudenz Danuser, Paul C. Goodwin
-
Publication number: 20140353524Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.Type: ApplicationFiled: August 18, 2014Publication date: December 4, 2014Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: GAUDENZ DANUSER, PAUL C. GOODWIN
-
Patent number: 8830314Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.Type: GrantFiled: June 28, 2012Date of Patent: September 9, 2014Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Gaudenz Danuser, Paul C. Goodwin
-
Patent number: 8828928Abstract: The inventions provided herein relate to amphiphilic peptides and particles comprising the amphiphilic peptides. Such amphiphilic peptides and particles described herein can be used as a delivery system, e.g., for therapeutic or diagnostic purposes, or as cell penetration vehicles or cell transfection agents.Type: GrantFiled: August 23, 2012Date of Patent: September 9, 2014Assignee: President and Fellows of Harvard CollegeInventors: Christian Dittrich, Gaudenz Danuser
-
Publication number: 20120268584Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.Type: ApplicationFiled: June 28, 2012Publication date: October 25, 2012Applicant: APPLIED PRECISION, INC.Inventors: GAUDENZ DANUSER, PAUL C. GOODWIN
-
Patent number: 8237786Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.Type: GrantFiled: March 31, 2010Date of Patent: August 7, 2012Assignee: Applied Precision, Inc.Inventors: Gaudenz Danuser, Paul C. Goodwin
-
Publication number: 20110149097Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.Type: ApplicationFiled: March 31, 2010Publication date: June 23, 2011Inventors: Gaudenz Danuser, Paul C. Goodwin