Abstract: Methods and Systems for evaluating visual impairment of a user. The methods and systems including generating, using a processor, a virtual reality environment; displaying at least portions of the reality environment on a head-mounted display, and measuring the performance of a user as user interacts with the virtual reality environment using at least one performance metric. Non-transitory computer readable storage medium comprising a sequence of instructions for a processor to execute the methods discussed herein.

Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized MYOC locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized MYOC locus express a human myocilin protein or a chimeric myocilin protein, fragments of which are from human myocilin. Methods are provided for using such non-human animals comprising a humanized MYOC locus to assess in vivo efficacy of human-myocilin-targeting reagents and reagents for treating glaucoma.

Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting ANGPTL7. The invention also relates to methods of using such dsRNA compositions to inhibit expression of ANGPTL7 and to methods of treating ANGPTL7-associated disorders, e.g., glaucoma, using such dsRNA compositions.

Abstract: The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.

Abstract: The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.

Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human angiopoietin like 7 (ANGPTL7) variant nucleic acid molecules and variant polypeptides, and ANGPTL7 variant nucleic acid molecules and variant polypeptides.

Abstract: The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.

Abstract: The present disclosure provides methods of treating subjects having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, and methods of detecting Angiopoietin-Like 7 (ANGPTL7) variant nucleic acid molecules and variant polypeptides.

Abstract: The present disclosure provides programmable osmotic-controlled oral compositions providing delayed extended release of a therapeutically acceptable amount of methylphenidate hydrochloride. The programmable osmotic-controlled compositions of the disclosure provide a lag time that is independent of the presence or absence of food, type of food, pH, gastric emptying, and volume of gastric fluid. The compositions of the disclosure can be programmed to provide a desired and precise lag time, and release drug, after the lag time, at a rhythm that matches the circadian rhythm of an individual being treated to optimize therapeutic outcome and minimize side effects.

Abstract: Methods and Systems for evaluating visual impairment of a user. The methods and systems including generating, using a processor, a virtual reality environment; displaying at least portions of the reality environment on a head-mounted display, and measuring the performance of a user as user interacts with the virtual reality environment using at least one performance metric. Non-transitory computer readable storage medium comprising a sequence of instructions for a processor to execute the methods discussed herein.

Abstract: Methods and systems that detect and define virtual objects in remote screens which do not expose objects. This permits simple and reliable automation of existing applications. In certain aspects a method for detecting objects from an application program that are displayed on a computer screen is disclosed. An image displayed on the computer screen is captured. The image is analyzed to identify blobs in the image. The identified blobs are filtered to identify a set of actionable objects within the image. Optical character recognition is performed on the image to detect text fields in the image. Each actionable object is linked to a text field positioned closest to a left or top side of the actionable object. The system automatically detects the virtual objects and links each actionable object such as textboxes, buttons, checkboxes, etc. to the nearest label object.

Abstract: The present technology relates to an extended-release solid oral pharmaceutical composition, comprising a cured blend of a melt-extruded first component and a second component, wherein the melt-extruded first component comprises a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof, at least one PEO polymer, and a stabilizing agent; and the second component comprises at least one PEO polymer and an oxidative stabilizing agent. The extended-release pharmaceutical compositions of the present technology provide crush-resistant and abuse-deterrent formulations featuring enhanced heat stability, resistance to drug segregation, and resistance to alcohol-induced dose dumping.

Abstract: Providing for analog averaging of optical black pixels of an image sensor is described herein. By way of example, optical black pixel signals can be output by a row of pixels and provided in a parallel manner to a readout circuit. The readout circuit can include an averaging circuit that, when activated, generates an analog average of signals received at the readout circuit. The analog average can be sampled at any suitable signal output of the readout circuit, or multiple samples can be acquired to mitigate temporal noise, improve yield, and so on. By utilizing analog averaging, optical black pixel information can be obtained much more quickly than with digital counterparts, and optical black pixels can be fully utilized, as well as utilized more flexibly, in generating the black pixel output. Further sensor die size can be reduced, by replacing digital adders, dividers or shifters with the averaging circuit.

Abstract: Providing for analog averaging of optical black pixels of an image sensor is described herein. By way of example, optical black pixel signals can be output by a row of pixels and provided in a parallel manner to a readout circuit. The readout circuit can include an averaging circuit that, when activated, generates an analog average of signals received at the readout circuit. The analog average can be sampled at any suitable signal output of the readout circuit, or multiple samples can be acquired to mitigate temporal noise, improve yield, and so on. By utilizing analog averaging, optical black pixel information can be obtained much more quickly than with digital counterparts, and optical black pixels can be fully utilized, as well as utilized more flexibly, in generating the black pixel output. Further sensor die size can be reduced, by replacing digital adders, dividers or shifters with the averaging circuit.

Abstract: An image sensor, system and method that alternates sub-sets of pixels with long exposure times and pixels with short exposure times on the same sensor to provide a sensor having improved Wide Dynamic Range (WDR). The sub-sets of pixels are reset at different time intervals after being read, which causes the respective integration times to vary. By combining information contained in the both the short and long integration pixels, the dynamic range of the sensor is improved.

Abstract: A reconfiguration manager is operable to reconfigure a repurposable recovery environment between a recovery environment for a production environment and a second environment different from the recovery environment. A storage system in the repurposable recovery environment periodically saves production information from the production environment while the repurposable recovery environment is operating as the second environment. The production information in the storage system is used to reconfigure the repurposable recovery environment from the second environment to the recovery environment.

Abstract: A reconfiguration manager is operable to reconfigure a repurposable recovery environment between a recovery environment for a production environment and a second environment different from the recovery environment. A storage system in the repurposable recovery environment periodically saves production information from the production environment while the repurposable recovery environment is operating as the second environment. The production information in the storage system is used to reconfigure the repurposable recovery environment from the second environment to the recovery environment.

Abstract: An apparatus and method for forming optical black pixels having uniformly low dark current. Optical Black opacity is increased without having to increase Ti/TiN layer thickness. A hybrid approach is utilized combining a Ti/TiN OB layer in conjunction with in-pixel metal stubs that further occlude the focal radius of each pixel's incoming light beam. Additional metal layers can be used to increase the opacity into the infrared region.

Abstract: An image sensor, system and method that alternates sub-sets of pixels with long exposure times and pixels with short exposure times on the same sensor to provide a sensor having improved Wide Dynamic Range (WDR). The sub-sets of pixels are reset at different time intervals after being read, which causes the respective integration times to vary. By combining information contained in the both the short and long integration pixels, the dynamic range of the sensor is improved.

Abstract: Apparatus and methods for synchronizing a plurality of image sensors in a video camera system. In one embodiment, a method includes generating a video sync signal, and resetting at least one internal clock divider in each image sensor in synchronization with the video sync signal at the beginning of each video frame. Another embodiment of a method of synchronizing a plurality of image sensors in a video camera system includes detecting a phase state of a signal of at least one internal clock divider in each sensor, wherein the phase state is relative to a system sync signal, and selecting a video output signal for each sensor based on the detected phase state of the at least one internal divider. In a third embodiment, the method includes asserting an asynchronous reset signal, stopping the system clocks in the system, de-asserting the asynchronous reset signal, while the system clocks are stopped, and restarting the system clocks.