Abstract: The present disclosure relates generally to improving operating room scheduling and resource management efficiency, and more specifically to techniques for monitoring various aspects of an operating room. An exemplary method for adjusting a surgical schedule specifying timing information for one or more surgeries to occur in an operating room comprises: receiving one or more images of the operating room captured by one or more cameras; detecting one or more surgical milestones of a plurality of predefined surgical milestones using one or more trained machine-learning models based on the received one or more images, wherein the one or more machine learning models are trained using a plurality of training images depicting the one or more surgical milestones; and adjusting, based on the detected one or more surgical milestones, the surgical schedule specifying timing information for the one or more surgeries to occur in the operating room.

Abstract: The present disclosure relates generally to improving surgical safety, and more specifically to techniques for automated detection of non-compliance to surgical protocols in a surgical environment such as an operating room. An exemplary method comprises: receiving one or more images of the operating room captured by one or more cameras; detecting a surgical milestone associated with a surgery in the operating room using a first set of one or more trained machine-learning models based on the received one or more images; detecting one or more activities in the operating room using a second set of one or more trained machine-learning models based on the received one or more images; and determining, based on the detected one or more activities and a surgical protocol associated with the detected surgical milestone, that an instance of non-compliance to the surgical protocol has occurred in the operating room.

Abstract: The present disclosure relates generally to improving surgery safety, and more specifically to monitoring various aspects of an operating room. An exemplary method for generating an alert to close a door of an operating room comprises: determining a status of the door of the operating room by: receiving one or more images of the door captured by one or more cameras; inputting the one or more images into a trained machine-learning model to obtain the status of the door, wherein the machine-learning model is trained using training images depicting open or closed doors; receiving one or more signals from one or more sensors in the operating room; determining, based on the one or more signals, whether an alert threshold is reached; and if the alert threshold is reached and the status of the door is open, generating the alert to close the door of the operating room.

Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 amino acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.

Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 ammo acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.

Abstract: Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload.

Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.

Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 ammo acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.

Abstract: A laundry treating appliance includes a cabinet, a treating chamber, and a treating chemistry dispenser provided with the cabinet and fluidly coupled to the treating chamber. The dispenser includes at least one dispenser pocket having a domed bottom and a side wall extending upwardly from the domed bottom. A plurality of outlets for a water/chemistry mixture can be defined between the domed bottom and the side wall. An angled inlet duct can project into the dispenser pocket in opposition to the domed bottom.

Abstract: Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload.

Abstract: A laundry treating appliance includes a cabinet, a treating chamber, and a treating chemistry dispenser provided with the cabinet and fluidly coupled to the treating chamber. The dispenser includes multiple compartments for treating chemistry, including multiple powder chemistry compartments and multiple liquid chemistry compartments. A cover for the dispenser includes a first lid selectively covering the multiple power chemistry compartments and a second lid selectively covering the multiple liquid chemistry compartments.

Abstract: A laundry treating appliance includes a cabinet, a treating chamber, and a treating chemistry dispenser provided with the cabinet and fluidly coupled to the treating chamber. The dispenser includes multiple compartments for treating chemistry, including multiple powder chemistry compartments and multiple liquid chemistry compartments. A cover for the dispenser includes a first lid selectively covering the multiple power chemistry compartments and a second lid selectively covering the multiple liquid chemistry compartments.

Abstract: A laundry treating appliance includes a cabinet, a treating chamber, and a treating chemistry dispenser provided with the cabinet and fluidly coupled to the treating chamber. The dispenser includes at least one dispenser pocket having a domed bottom and a side wall extending upwardly from the domed bottom. A plurality of outlets for a water/chemistry mixture can be defined between the domed bottom and the side wall. An angled inlet duct can project into the dispenser pocket in opposition to the domed bottom.

Abstract: Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload.

Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.

Abstract: A laundry treating appliance includes a cabinet, a treating chamber, and a treating chemistry dispenser provided with the cabinet and fluidly coupled to the treating chamber. The dispenser includes a dispenser container having multiple dispenser pockets configured to receive a dose of treating chemistry and a water inlet duct configured to supply water to one of the dispenser pockets to flush treating chemistry from the pocket. The water inlet duct can be slidingly coupled with the dispenser container and can project into an interior of the pocket.