Patents by Inventor Gautam Kumar Das

Gautam Kumar Das has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARATION OF SUCCINYLCHOLINE CHLORIDE
    Publication number: 20140100385
    Abstract: The present invention relates to a process for the preparation of succinylcholine chloride, a pharmaceutically active compound used as skeletal muscle relaxant which comprises condensing succinic anhydride with N,N-diemthylaminoethanol using a catalyst in presence of a solvent to form bis[2-(dimethylamino)ethyl]succinate; in situ purifying the bis[2-(dimethylamino)ethyl]succinate using a base; reacting pure bis[2-(dimethylamino)ethyl]succinate with methyl chloride gas using an alcohol; and purifying the obtained crude succinylcholine chloride using water and alcohol.
    Type: Application
    Filed: February 20, 2013
    Publication date: April 10, 2014
    Applicant: SEQUENT SCIENTIFIC LIMITED
    Inventors: Mahalinga MANJATHURU, Anil Narayan MAYEKAR, Pejakala Kakrannaya VASUDEVA, Thangavel ARULMOLI, Gautam Kumar DAS
  • Synthesis of ceftiofur intermediate
    Patent number: 6803461
    Abstract: The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: October 12, 2004
    Assignee: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
  • Process for the preparation of cefixime
    Patent number: 6800755
    Abstract: The present invention provides an improved process for the preparation of cefixime of formula (I), with an improved quality having/possessing better color and solubility: the process includes the steps of dissolving the compound of formula (II) in water/water immisible solvent using sodium bicarbonate at a temperature in the range of 0° C. to the 35° C., hydrolyzing with sodium hydroxide at a temperature in the range of 0° C. to 25° C., and acidifying the resultant mass to 2.3 to 3.0 with dilute acid in the presence or absence of solvent at a temperature in the range of 10° C. to 45° C.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: October 5, 2004
    Assignee: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Gautam Kumar Das, Pramod Narayan Deshpande, Ramasubbu Chandrasekaran, Padmanabhan Ramar, John Muthiah Raja Jeyakumar
  • Process for the preparation of cefuroxime sodium
    Publication number: 20040092735
    Abstract: The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).
    Type: Application
    Filed: December 5, 2002
    Publication date: May 13, 2004
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Gautam Kumar Das, John Muthiah Raja Jeyakumar
  • Process for the preparation of cefixime
    Publication number: 20040082560
    Abstract: The present invention provides an improved process for the preparation of cefixime of formula (I), with an improved quality having/possessing better color and solubility.
    Type: Application
    Filed: December 5, 2002
    Publication date: April 29, 2004
    Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED
    Inventors: Pandurang Balwant Deshpande, Gautam Kumar Das, Pramod Narayan Deshpande, Ramasubbu Chandrasekaran, Padmanabhan Ramar, John Muthiah Raja Jeyakumar
  • Process for the preparation of cefadroxil
    Publication number: 20040077849
    Abstract: The present invention relates to an improved process for the preparation of cefadroxil of the formula (I), more particularly, the present invention relates to an improved process for the preparation of cefadroxil having water content in the range of 4-5%.
    Type: Application
    Filed: December 5, 2002
    Publication date: April 22, 2004
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pramod Narayan Deshpande, Gautam Kumar Das, Rajendra Janardan Sarangdhar, Peter Xavier Tharial
  • Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
    Patent number: 6610845
    Abstract: The present invention provides new thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1 represents H, trityl, CH3, CRaRbCOOR2 (Ra and Rb independently of one another represents hydrogen or methyl and R2 represents H or C1-C4 alkyl). also, the invention provides a method by which the said thioester derivatives can be prepared by reacting thiazolyl acetic acid of the general formula (IV) with 1,2,5,6 tetrahdro-2-methyl-5,6 dioxo-1,2,4-triazin-3-thiol of the formula (VI) in a solvent, in presence of an organic base and with the help of Vilsmeier reagent of the formula (V). The so obtained thioester derivatives are reacted with 7-amino-cephem carboxylic acids of the general formula (III) to produce cephalosporin antibiotic compounds having the general formula (II).
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: August 26, 2003
    Assignee: Orchid Chemicals & Pharmaceuticals Limited, India
    Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Shanmugam Srinivasan, Parven Kumar Luthra, Gautam Kumar Das
  • Synthesis of ceftiofur intermediate
    Publication number: 20030135041
    Abstract: The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid represented by formula (I) 1
    Type: Application
    Filed: January 4, 2002
    Publication date: July 17, 2003
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED, INDIA
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
  • Synthesis of ceftiofur intermediate
    Publication number: 20030130502
    Abstract: The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.
    Type: Application
    Filed: August 1, 2002
    Publication date: July 10, 2003
    Applicant: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das