Abstract: Systems and methods for optimizing drug management are disclosed. A disclosed system implements a method that includes receiving, from a first client system, a new drug code and drug information associated with new drug code, determining, by the computing system based on the received drug information, a predetermined medication and a first local identifier used by the first client system to identify the predetermined medication, determining, based at least in part on identifying the first local identifier, one or more second local identifiers that identify the predetermined medication, identifying, based on the one or more second local identifiers, a plurality of second client systems that use the one or more second local identifiers, and automatically providing, an instruction to each of the plurality of second client systems to associate, at the second client system, one or more corresponding second local identifiers with the new drug code.