Abstract: A method of removing THC and THCA from a non-decarboxylated hemp extract, the non-decarboxylated hemp extract including THC and THCA and at least one cannabinoid is provided. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.1 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Abstract: A method of removing THC and/or THCA from a mixture, the mixture including THC and/or THCA and at least one cannabinoid is provided. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.3 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Abstract: Embodiments of a method of purifying tetrahydrocannabinol (THC) from a composition containing THC and at least one impurity, e.g., from pesticides, waxes, lipids, pigments, and other cannabinoids, can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The THC products can be used in various pharmaceutical and nutraceutical applications.

Abstract: Disclosed is a process for the production of high purity alpha-tocotrienol from palm oil extract. More particularly, the invention relates to a process for the separation of alpha-tocotrienol from a mixtures of other tocotrienols and tocopherols and the use of a simplified separation scheme based on a combination of solid phase extraction and simulated moving bed (SMB) separation steps employing polar phase simulated moving bed operation. The process is useful for providing a continuous route and a simplified processing route to providing pure alpha-tocotrienol as a major product essentially free of other tocotrienols and tocopherols including: beta-tocopherol, gamma-tocotrienol, delta-tocotrienol, gamma-tocopherol, delta-tocopherol, front end and back end carotenoids, and alpha-tocopherol as a by-product from palm oil extract. Alpha-tocotrienol is a form of vitamin E and may be useful as a treatment for preventing stroke or reducing brain and nerve damage following a stroke.

Abstract: Disclosed is a process for the production of high purity alpha-tocotrienol from palm oil extract. More particularly, the invention relates to a process for the separation of alpha-tocotrienol from a mixtures of other tocotrienols and tocopherols and the use of a simplified separation scheme based on a combination of solid phase extraction and simulated moving bed (SMB) separation steps employing polar phase simulated moving bed operation. The process is useful for providing a continuous route and a simplified processing route to providing pure alpha-tocotrienol as a major product essentially free of other tocotrienols and tocopherols including: beta-tocopherol, gamma-tocotrienol, delta-tocotrienol, gamma-tocopherol, delta-tocopherol, front end and back end carotenoids, and alpha-tocopherol as a by-product from palm oil extract. Alpha-tocotrienol is a form of vitamin E and may be useful as a treatment for preventing stroke or reducing brain and nerve damage following a stroke.