Patents by Inventor Gavin C. Hirst

Gavin C. Hirst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolopyrimidines as therapeutic agents
    Patent number: 6660744
    Abstract: The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: December 9, 2003
    Assignee: Abbott GmbH & Co. KG
    Inventors: Gavin C. Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D. Arnold, Michael M. Friedman
  • Kinase inhibitors
    Publication number: 20030225098
    Abstract: The present application is directed to pyrazolopyrirnidine and furopyrimidine analogs of the formula (I) 1
    Type: Application
    Filed: March 21, 2003
    Publication date: December 4, 2003
    Inventors: Gavin C. Hirst, Lee D. Arnold, Andrew Burchat, Neil Wishart, David Calderwood, Carol K. Wada, Michael R. Michaelides, Zhiqin Ji, Melanie Muckey
  • Kinase inhibitors
    Publication number: 20030199525
    Abstract: The present application is directed to pyrazolopyrimidine and furopyrimnidine analogs of the formula (I) 1
    Type: Application
    Filed: March 21, 2002
    Publication date: October 23, 2003
    Inventors: Gavin C. Hirst, Lee D. Arnold, Andrew Burchat, Neil Wishart, Carol K. Wada, Michael R. Michaelides, Zhiqin Ji, Melanie Muckey
  • 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20030187001
    Abstract: Chemical compounds having structural formula I 1
    Type: Application
    Filed: September 17, 1999
    Publication date: October 2, 2003
    Inventors: DAVID CALDERWOOD, LEE ARNOLD, HORMOZ MAZDIYASNI, GAVIN C. HIRST, BOJUAN B. DENG, DAVID N. JOHNSTON, PAUL RAFFERTY, GERALD B. TOMETZKI, HELEN L. TWIGGER, RAINER MUNSCHAUER
  • Method of identifying inhibitors of Lck
    Publication number: 20030175935
    Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.
    Type: Application
    Filed: August 5, 2002
    Publication date: September 18, 2003
    Inventors: David W. Borhani, David Calderwood, Richard W. Dixon, Gavin C. Hirst, Peter Hrnciar, Andreas Loew, Adelaine Leung, Kurt Ritter
  • Pyrrolopyrimidines as therapeutic agents
    Publication number: 20030153752
    Abstract: Chemical compounds having structural formula I 1
    Type: Application
    Filed: March 29, 2000
    Publication date: August 14, 2003
    Inventors: Gavin C. Hirst, David Calderwood, Rainer Munschauer, Lee D. Arnold, David N. Johnston, Paul Rafferty
  • Pyrazolopyrimidines as therapeutic agents
    Publication number: 20020156081
    Abstract: The present invention provides compounds of Formula I, 1
    Type: Application
    Filed: March 22, 2001
    Publication date: October 24, 2002
    Applicant: Abbott Laboratories
    Inventors: Gavin C. Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D. Arnold, Michael M. Friedman
  • Modulators of cholecystokinin
    Patent number: 5508432
    Abstract: CCK modulators, e.g. agonists or antagonists, of the following formula (I): ##STR1## or a base-addtion salt thereof.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: April 16, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Elizabeth E. Sugg, Milana Dezube, Gavin C. Hirst
  • Modulators of cholecystokinin
    Patent number: 5380872
    Abstract: CCK modulators, e.g. agonists or antagonists, of the following formula (I): ##STR1## or a base-addtion salt thereof.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: January 10, 1995
    Assignee: Glaxo Inc.
    Inventors: Elizabeth E. Sugg, Milana Dezube, Gavin C. Hirst