Patents by Inventor Gavin Hirst

Gavin Hirst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 9296763
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: March 29, 2016
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 8680136
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 25, 2014
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20130345172
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: July 29, 2013
    Publication date: December 26, 2013
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Amino-tetrazoles analogues and methods of use
    Patent number: 8546374
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: October 1, 2013
    Assignee: Abbvie Inc.
    Inventors: William A. Carroll, Arturo Perez-Medrano, Alan S. Florjancic, Derek W. Nelson, Sridhar Peddi, Tongmei Li, Eric M. Bunnelle, Gavin Hirst, Biquin C. Li
  • AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE
    Publication number: 20120329772
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Application
    Filed: July 9, 2012
    Publication date: December 27, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: William A. Carroll, Arturo Perez-Medrano, Alan S. Florjancic, Derek W. Nelson, Sridhar Peddi, Tongmei Li, Eric M. Bunnelle, Gavin Hirst, Biqin C. Li
  • Fused ring heterocycle kinase modulators
    Patent number: 8242280
    Abstract: The present invention provides fused ring heterocycles as kinase modulators, pharmaceutical compositions containing these modulators, and methods of using these modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: August 14, 2012
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Gavin Hirst, Stephanie Hopkins, Khanh Thi Tuong Nguyen, Richard Pracitto, Paul E. Sprengeler, Ruo W. Steensma
  • Amino-tetrazoles analogues and methods of use
    Patent number: 8217067
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: July 10, 2012
    Assignee: Abbott Laboratories
    Inventors: William A. Carroll, Arturo Perez-Medrano, Alan S. Florjancic, Derek W. Nelson, Sridhar Peddi, Tongmei Li, Eric M. Bunnelle, Gavin Hirst, Biqin C. Li
  • Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
    Patent number: 8178490
    Abstract: Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: May 15, 2012
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Olga Rodny, Keith A. Bostian, David M. Wallace, Robert I. Higuchi, Chun Chow, Chi Ching Mak, Gavin Hirst, Brian Eastman
  • Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
    Patent number: 8158647
    Abstract: Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: April 17, 2012
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: Jeffrey M. Blaney, Andreas Gosberg, Stefan N. Gradl, Gavin Hirst, Stephanie A. Hopkins, Paul A. Sprengeler, Ruo W. Steensma, Johnny Uy
  • CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20120040932
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: August 8, 2011
    Publication date: February 16, 2012
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF
    Publication number: 20100152098
    Abstract: Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
    Type: Application
    Filed: November 5, 2009
    Publication date: June 17, 2010
    Applicant: Mpex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Olga Rodny, Keith A. Bostian, David M. Wallace, Robert I. Higuchi, Chun Chow, Chi Ching Mak, Gavin Hirst, Brian Eastman
  • Amino-tetrazole analogues and methods of use
    Patent number: 7704997
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: April 27, 2010
    Assignee: Abbott Laboratories
    Inventors: William A. Carroll, Arturo Perez-Medrano, Alan S. Florjancic, Derek W. Nelson, Sridhar Peddi, Tongmei Li, Eric M. Bunnelle, Gavin Hirst, Biqin C. Li
  • SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS
    Publication number: 20090005356
    Abstract: Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis.
    Type: Application
    Filed: May 29, 2008
    Publication date: January 1, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: Jeffrey M. Blaney, Andreas Gosberg, Stefan N. Gradl, Gavin Hirst, Stephanie A. Hopkins, Paul A. Sprengeler, Ruo W. Steensma, Johnny Uy
  • FUSED RING HETEROCYCLE KINASE MODULATORS
    Publication number: 20080261921
    Abstract: The present invention provides fused ring heterocycles as kinase modulators, pharmaceutical compositions containing these modulators, and methods of using these modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: April 10, 2008
    Publication date: October 23, 2008
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Gavin Hirst, Stephanie Hopkins, Khanh Thi Tuong Nguyen, Richard Pracitto, Paul E. Sprengeler, Ruo W. Steensma
  • Amino-Tetrazoles Analogues and Methods of Use
    Publication number: 20080171733
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 17, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: William A. Carroll, Arturo Perez-Medrano, Alan S. Florjancic, Derek W. Nelson, Sridhar Peddi, Tongmei Li, Eric M. Bunnelle, Gavin Hirst, Biqin C. Li
  • Piperazines as P2X7 antagonists
    Publication number: 20080076924
    Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
    Type: Application
    Filed: June 29, 2007
    Publication date: March 27, 2008
    Inventors: Patrick Betschmann, William Carroll, Anna Ericsson, Shannon Fix-Stenzel, Michael Friedman, Gavin Hirst, Nathan Josephsohn, Biqin Li, Arturo Perez-Medrano, Michael Morytko, Paul Rafferty, Haipeng Chen
  • THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS
    Publication number: 20070155776
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: February 15, 2007
    Publication date: July 5, 2007
    Inventors: Patrick Betschmann, Andrew Burchat, David Calderwood, Michael Curtin, Steven Davidsen, Heather Davis, Robin Frey, Howard Heyman, Gavin Hirst, Peter Hrnciar, Michael Michaelides, Melanie Muckey, Kelly Mullen, Paul Rafferty, Carol Wada
  • Novel imidazo based heterocycles
    Publication number: 20070099925
    Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Application
    Filed: September 1, 2006
    Publication date: May 3, 2007
    Inventors: David Calderwood, Kristine Frank, Patrick Betschmann, Gavin Hirst, Eric Brieinlinger, Michael Morytko, Richard Dixon
  • Amino-tetrazoles analogues and methods of use
    Publication number: 20070049584
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Application
    Filed: April 29, 2005
    Publication date: March 1, 2007
    Inventors: William Carroll, Arturo Perez-Medrano, Alan Florjancic, Derek Nelson, Sridhar Peddi, Tongmei Li, Eric Bunnelle, Gavin Hirst, Biquin Li
  • Amino-tetrazole analogues and methods of use
    Publication number: 20060052374
    Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
    Type: Application
    Filed: September 7, 2005
    Publication date: March 9, 2006
    Inventors: William Carroll, Arturo Perez-Medrano, Alan Florjancic, Derek Nelson, Sridhar Peddi, Tongmei Li, Eric Bunnelle, Gavin Hirst, Biquin Li