Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: Disclosed herein is a computer-implemented method comprising aggregating PFAS remediation evaluation data for a plurality of remediation options and for a plurality of predefined criteria; graphically displaying the user modifiable chart comprising the plurality of graphical representations of the aggregated PFAS remediation evaluation data, wherein: each graphical representation depicts data points visually plotted with weights, the plurality of graphical representations for the plurality of predefined criteria are visually ordered according to a rank of the plurality of predefined criteria, and the weights are based on the rank of the plurality of predefined criteria; detecting a first user input modifying the rank of at least one predefined criterion; in accordance with the first user input, automatically updating the weights of the data points; and displaying an updated user modifiable chart comprising the plurality of graphical representations of the aggregated PFAS remediation evaluation data.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: An oil well pump system includes a programmable control module configured to be coupled to a fuel injector coupled to a prime mover engine. The programmable control module is configured to cause the fuel injector and engine to operate in a 350-500 RPM range. A generator is configured to be coupled to the engine, the generator is configured to operate in a 350-500 RPM range and configured to be coupled to the programmable control module and the fuel injector and configured to supply sufficient power to operate the programmable control module and the fuel injector.

Abstract: A method and system are disclosed for automatic replenishment of a retail enterprise store, and a computer-readable storage medium. In the method of the present disclosure, historical operational transaction data of at least one store of the same type as the retail enterprise store is used to obtain four indicators of each product of the at least one store, a plurality of target features having an impact on an indicator matrix composed of the four indicators are extracted to provide replenishment suggestions, and the indicator matrix composed of the four indicators is automatically adjusted to update a replenishment model. In the embodiments of the present disclosure, a set of algorithm models can be optimized and customized according to the historical operational transaction data of the store and external environments such as weather changes, business circle customer flow, discount events, etc.

Abstract: Cot fastening systems which fix and hold an emergency cot to a crash stable, cot fastener track included in the system and provided within an emergency vehicle and methods of affixing the emergency cot thereto are disclosed. The track has a longitudinal length with first and second ends, open side rails longitudinally extending between the ends, and a channel centrally located between the rails. The side rails align, accommodate and guide a first fixture of the cot towards the first end as the cot is rolled within the vehicle and to retain the first fixture adjacent the first end at least vertically and laterally therein. The channel accommodates therein and retains a second fixture adjacent the second end at least vertically and laterally therein. A securing mechanism releasably prevents removal of the first fixture from the open side rails and removal of the second fixture from the channel.

Abstract: An apparatus includes a substrate and a reader deposited on the substrate. A laser is formed on a non-self supporting structure and bonded to the substrate. A plurality of heat sink layers are deposited between the reader and the laser and configured to provide thermal coupling between the substrate and the laser and sink heat away from the laser. A waveguide is deposited proximate the laser. The waveguide is configured to communicate light from the laser to a near-field transducer that directs energy resulting from plasmonic excitation to a recording medium.

Abstract: An exercise device that allows users to exercise in a manner that strengthens their core and improve their balance with respect to rotation. The device includes a base for placing on the ground and a board on which the user stands and a mechanism for adjusting a restoring force to a neutral position. The device may also include a mechanism for limiting the range of rotational motion of the board.

Abstract: An apparatus includes a substrate and a reader deposited on the substrate. A laser is formed on a non-self supporting structure and bonded to the substrate. A plurality of heat sink layers are deposited between the reader and the laser and configured to provide thermal coupling between the substrate and the laser and sink heat away from the laser. A waveguide is deposited proximate the laser. The waveguide is configured to communicate light from the laser to a near-field transducer that directs energy resulting from plasmonic excitation to a recording medium.

Abstract: An apparatus includes a substrate and a reader deposited on the substrate. A laser is formed on a non-self supporting structure and bonded to the substrate. A plurality of heat sink layers are deposited between the reader and the laser and configured to provide thermal coupling between the substrate and the laser and sink heat away from the laser. A waveguide is deposited proximate the laser. The waveguide is configured to communicate light from the laser to a near-field transducer that directs energy resulting from plasmonic excitation to a recording medium.

Abstract: In one embodiment, a secure substrate provides a print-ready surface for printing scratch-off products and eliminates the need to print lower security layers for protecting against attempts to view hidden indicia information. In one embodiment, a secure substrate comprises applying microperforations to a dyed substrate that meets a predefined transmission optical density to resist an attempt to reduce the opacity of the dyed substrate by delamination. In another embodiment, a secure substrate comprises applying a lower opacity layer and a lower background layer on a substrate to provide a secure substrate that meets a predefined transmission optical density. In another embodiment, a secure substrate comprises applying a lower opacity layer on a substrate, applying a reflective coating, and applying a lower background layer over the reflective coating to provide a secure substrate that meets a predefined transmission optical density.

Abstract: Cot fastening systems which fix and hold an emergency cot to a crash stable, cot fastener track included in the system and provided within an emergency vehicle and methods of affixing the emergency cot thereto are disclosed. The track has a longitudinal length with first and second ends, open side rails longitudinally extending between the ends, and a channel centrally located between the rails. The side rails align, accommodate and guide a first fixture of the cot towards the first end as the cot is rolled within the vehicle and to retain the first fixture adjacent the first end at least vertically and laterally therein. The channel accommodates therein and retains a second fixture adjacent the second end at least vertically and laterally therein. A securing mechanism releasably prevents removal of the first fixture from the open side rails and removal of the second fixture from the channel.

Abstract: Cot fastening systems (2) which fix and hold an emergency cot (14) to a crash stable cot fastener track (12) provided within an emergency vehicle (8). The track (12) has a longitudinal length with front (85) and back ends (80), open side rails (28, 30) longitudinally extending between the ends, and a channel (86, 88) centrally located between the rails. The side rails (28, 30) align, accommodate and guide a forward fixture (4) of the cot towards the front end (85) as the cot (14) is rolled within the vehicle to retain the forward fixture (4) adjacent the front end (85) at least vertically and laterally. The channel (86, 88) accommodates and retains a rearward fixture (6) adjacent the back end (80) at least vertically and laterally. A securing mechanism (70,102) releasably prevents removal of the forward fixture (4) from the open side rails and removal of the rearward fixture (6) from the channel (86, 88).

Abstract: An exercise device that allows users to exercise in a manner that strengthens their core and improve their balance with respect to rotation. The device includes a base for placing on the ground and a board on which the user stands, and includes a pivot between the base and board. The exercise device has a neutral position and also provides a restoring force when the user rotates the board. The restoring force is determined by the shape of the pivot and the supporting elements on the board and/or base.

Abstract: In one embodiment, a secure substrate provides a print-ready surface for printing scratch-off products and eliminates the need to print lower security layers for protecting against attempts to view hidden indicia information. In one embodiment, a secure substrate comprises applying microperforations to a dyed substrate that meets a predefined transmission optical density to resist an attempt to reduce the opacity of the dyed substrate by delamination. In another embodiment, a secure substrate comprises applying a lower opacity layer and a lower background layer on a substrate to provide a secure substrate that meets a predefined transmission optical density. In another embodiment, a secure substrate comprises applying a lower opacity layer on a substrate, applying a reflective coating, and applying a lower background layer over the reflective coating to provide a secure substrate that meets a predefined transmission optical density.

Abstract: An apparatus and method is presented for receiving and displaying user messages associated with multimedia content. Specifically, the present invention is directed to controlling the operation of a television recording/playback system to permit a user to input a message, associate that message with a selected television program, and display the associated message when the selected television program is accessed by another user (see FIG. 1). The apparatus of the present invention is directed to a system for managing multimedia content including devices for storing television programs and associating with those programs user-generated messages for display to other system users. In this way, the present invention provides content management tools that promote sharing by all users, ease the process of establishing a consensus for managing limited resources, and encourage monitoring by the administrator.

Abstract: In one embodiment, a secure substrate provides a print-ready surface for printing scratch-off products and eliminates the need to print lower security layers for protecting against attempts to view hidden indicia information. In one embodiment, a secure substrate comprises applying microperforations to a dyed substrate that meets a predefined transmission optical density to resist an attempt to reduce the opacity of the dyed substrate by delamination. In another embodiment, a secure substrate comprises applying a lower opacity layer and a lower background layer on a substrate to provide a secure substrate that meets a predefined transmission optical density. In another embodiment, a secure substrate comprises applying a lower opacity layer on a substrate, applying a reflective coating, and applying a lower background layer over the reflective coating to provide a secure substrate that meets a predefined transmission optical density.

Abstract: In one embodiment, a secure substrate provides a print-ready surface for printing scratch-off products and eliminates the need to print lower security layers for protecting against attempts to view hidden indicia information. In one embodiment, a secure substrate comprises applying microperforations to a dyed substrate that meets a predefined transmission optical density to resist an attempt to reduce the opacity of the dyed substrate by delamination. In another embodiment, a secure substrate comprises applying a lower opacity layer and a lower background layer on a substrate to provide a secure substrate that meets a predefined transmission optical density. In another embodiment, a secure substrate comprises applying a lower opacity layer on a substrate, applying a reflective coating, and applying a lower background layer over the reflective coating to provide a secure substrate that meets a predefined transmission optical density.