Patents by Inventor Gavin T. Knight

Gavin T. Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Culture Substrates for Controlled Induction of Biomimetic Neural Tissues Comprising Singular Rosette Structures
    Publication number: 20230383247
    Abstract: Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising one or more rosette structures. Preferably, the methods provided herein direct differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising a singular neural rosette structure that is comparable to at least a portion of the developing human neural tube. Also described are engineered neural tissue preparations comprising biomimetic neural tissues comprising a singular rosette structure having regional neural progenitor phenotypes.
    Type: Application
    Filed: August 11, 2023
    Publication date: November 30, 2023
    Inventors: Randolph Scott Ashton, Gavin T. Knight
  • Methods and culture substrates for controlled induction of biomimetic neural tissues comprising singular rosette structures
    Patent number: 11767508
    Abstract: Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising one or more rosette structures. Preferably, the methods provided herein direct differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising a singular neural rosette structure that is comparable to at least a portion of the developing human neural tube. Also described are engineered neural tissue preparations comprising biomimetic neural tissues comprising a singular rosette structure having regional neural progenitor phenotypes.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: September 26, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Randolph Scott Ashton, Gavin T. Knight
  • METHODS AND CULTURE SUBSTRATES FOR CONTROLLED INDUCTION OF BIOMIMETIC NEURAL TISSUES COMPRISING SINGULAR ROSETTE STRUCTURES
    Publication number: 20190024046
    Abstract: Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising one or more rosette structures. Preferably, the methods provided herein direct differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising a singular neural rosette structure that is comparable to at least a portion of the developing human neural tube. Also described are engineered neural tissue preparations comprising biomimetic neural tissues comprising a singular rosette structure having regional neural progenitor phenotypes.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 24, 2019
    Inventors: Randolph Scott Ashton, Gavin T. Knight