Abstract: Disclosed is a method of calibrating an apparatus comprising at least one sensor for detecting one or more analytes of interest in a sample, the method comprising measuring a first set of responses of the at least one sensor to at least one first calibration solution having a known composition of the one or more analytes of interest; measuring a second response of the at least one sensor to a second calibration solution having an approximately known composition of the one or more analytes of interest; determining the composition of the second calibration solution from the difference between the first set of responses and the second response; and periodically calibrating the at least one sensor with the second calibration solution using said determined composition. An apparatus and computer program product for executing this method are also disclosed.

Abstract: Methods and systems for calibrating a sensor for measuring an analyte in a patient monitoring system are disclosed. The method includes calculating sensor drift; calibrating the sensor using at least one calibration fluid; and periodically updating the sensor calibration based on the sensor drift calculation. The system adjusts a gas concentration in a fluid. The method in one of several variations includes providing a calibration fluid; setting the analyte concentration in the first fluid to a first concentration with an adjustment mechanism; measuring the first analyte concentration with the sensor; setting the analyte concentration in the first fluid to a second concentration; measuring the second analyte concentration with the sensor; and determining the calibration coefficients for the sensor from the measured first and second analyte concentrations.

Abstract: The present application discloses a number of methods of calibrating a sensor for measuring an analyte in a patient monitoring system. In a first embodiment, the method comprises calculating a sensor drift; calibrating the sensor using at least one calibration fluid; and periodically updating the sensor calibration based on the sensor drift calculation. In a second embodiment, the system comprises means for adjusting a gas concentration in a fluid, and the method comprises providing a calibration fluid; setting the analyte concentration in the first fluid to a first concentration with said adjusting means; measuring the first analyte concentration with the sensor; setting the analyte concentration in the first fluid to a second concentration with said adjusting means; measuring the second analyte concentration with the sensor; and determining the calibration coefficients for the sensor from the measured first analyte concentration and the measured second analyte concentration.

Abstract: This invention relates to a sensor suitable for detecting the presence of one or more analytes. The sensor comprises a substrate; a confinement structure disposed on the substrate, wherein the confinement structure comprises at least a first limiting structure defining a first interior space; a transducer proximal to the first interior space; and a first synthetic polymer capable of selectively binding a first analyte, within the confinement structure. The confinement structure may have a second or further limiting structure defining a second or further interior space containing the first or preceding interior space. The sensor may also have additional confinement structures containing different materials for detecting additional analytes or taking reference measurements.