Abstract: A time-ordered series of measurements of a polymer made during translocation of the polymer through a Nanopore are analysed. The measurements are dependent on the identity of k-mers in the Nanopore, a k-mer bring k polymer units of the polymer, where k is a positive integer. The method involves deriving, from the series of measurements, a feature vector of time-ordered features representing characteristics of the measurements; and determining similarity between the derived feature vector and at least one other feature vector.

Abstract: An immersed membrane cassette has a high tank intensity achieved by one or more of: reduced module to module gap; using structural hollow tubing in at least parts of a frame in place of separate permeate and/or air pipes; and, using vertical permeate port connections. The cassette has a tank intensity over 650 m2/m2. The cassette may be combined with a fine screen. This specification also describes an immersed membrane module having a permeate port and/or connector on the top of a header. The permeate connection between the module and a permeate collection tube may be vertical, i.e. perpendicular to the length of the header. A piston seal may be used between the permeate port of the header and the permeate collection tube. The permeate collection tube may be a horizontal structural member on the periphery of a frame that holds the module.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: An internal combustion engine controller comprising a memory and a processor is provided. The memory is configured to store a plurality of control maps, each control map defining a hypersurface of actuator setpoints for controlling an actuator of the internal combustion engine based on a plurality of input variables to the internal combustion engine controller. The processor comprises an engine setpoint module and a map updating module. The engine setpoint module is configured to output a control signal to each actuator based on a location on the hypersurface of the respective control map defined by the plurality of input variables. The map updating module is configured to calculate an optimised hypersurface for at least one of the control maps. The optimised hypersurface is calculated based on a real-time performance model of the internal combustion engine comprising sensor data from the internal combustion engine and the plurality of input variables.

Abstract: A dispensing apparatus (200) configured for dispensing a composition (111) comprises at least one inlet (251) configured for receiving a composition (111); at least one outlet (252) configured for dispensing the composition (111); at least one directional flow valve (250) located between the at least one inlet (251) and the at least one outlet (252); and at least one regulating module (260) in fluid communication with a respective directional flow valve (250), wherein the at least one regulating module (260) is configured to control and/or regulate flow of the composition (111) to at least one outlet (252).

Abstract: A method of provisioning a network may include, with a network controller, identifying a first network intent of a computing network based at least in part on an execution of a user interface (UI) or API layer at a client device, and identifying a modification of at least one object within the first network intent within the UI or API layer at the client device as the first network intent is being modified. The modification defines a delta between the first network intent and a second network intent. The method may further include, with a provisioning service executed by the network controller, receiving the delta as a payload from the client device, and provisioning at least one computing device within the computing network based at least in part on the delta. The method further includes automatically modifying the at least one object based on the received delta, including a further modification of the second network intent.

Abstract: An apparel location determining system for automatically determining the location of a user-specified wearable item within a plurality of possible independent inventory systems is described with each inventory system being located in a unique geographic location. The system has a user profile database with user records associated with different users. A user record may have a list of wearable items that are required by a corresponding user. The list of wearable items includes a list of composite descriptors of the wearable items. Each composite descriptor includes a user-selected type of wearable item and a user-specific predetermined size of the user. An availability database includes information relating to the availability of specific wearable items at each of the plurality of independent inventory systems. A central server interacts with a mobile telecommunications device.

Abstract: A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units.

Abstract: Multiplexed phased array sonar systems and methods for consumer fishfinders are described herein. In one embodiment a single curved transmit transducer and an array of receive transducers are provided, and in an embodiment the signals from the receive transducers are multiplexed, which greatly reduces the data load, allowing for the achievement of the near real time, high resolution imagery in a size and price point that enables this technology to be employed in a consumer fish finder.

Abstract: An internal combustion engine controller for an internal combustion engine comprising a memory and a processor. The memory is configured to store a plurality of control maps, each control map defining a hypersurface of actuator setpoints for controlling an actuator of the internal combustion engine based on a plurality of input variables to the internal combustion engine controller. The processor comprises a map updating module, a parameter updating module and an engine setpoint module. The map updating module is configured to calculate an optimised hypersurface for at least one of the control maps based on a performance objective function of the internal combustion engine, sensor data from the internal combustion engine, and the plurality of input variables, wherein the performance objective function includes parameters. The parameter updating module is configured to update a parameter of the performance objective function upon determining a change in an operating condition of the internal combustion engine.

Abstract: A system for automatically determining the location of a user-specified item within a plurality of possible independent inventory systems is described where each inventory system is located in a different unique geographic location. The system comprises a user profile database comprising a plurality of user records associated with a plurality of different users; at least one of the user records comprising a list of items that are required by a corresponding user; an availability database for providing information relating to the availability of specific items at each of the plurality of inventory systems, a central server for interacting with a mobile telecommunications device.

Abstract: The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where A, Z, Y, RA, Linker and v have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts thereof in methods of treatment of the human or animal body, for example in the prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.

Abstract: A computer implemented design tool configured to design a powertrain is provided. The design tool utilises and input file comprising architecture selection constraints and load requirements for the powertrain to be designed along with a generic powertrain component library. The generic powertrain component library comprises configurable models of powertrain components. The design tool generates candidate powertrain architectures based on the input file and the generic powertrain component library. The design tool also generated candidate parameters for each of the components in each candidate powertrain architecture. The design tool is configured to calculate optimised component parameters for each candidate powertrain architecture. The design tool then outputs an optimised powertrain architecture based on the candidate powertrain architectures evaluated.

Abstract: A machine includes an engine, a selective catalytic reduction (SCR) element fixedly connected to an output of the engine, and a controller. The controller is communicatively coupled to the engine and a sensor at an output of the SCR element. The controller is configured to calculate an estimated amount of emissions at a location of the SCR element, calculate an estimated amount of emissions from an output of the SCR element, measure, using the sensor, an actual amount of emissions from the output of the SCR element, and perform a comparison of the estimated amount of emissions and the actual amount of emissions. The controller is further configured to adjust, based on the comparison, the estimated amount of emissions at the location of the SCR element, and control operation of the engine based on the adjusted amount of emissions.

Abstract: A cooking appliance includes a cooktop having at least one heating element for heating a cookware member on or to be placed on the cooktop, the at least one heating element being adjustable between a working-power level wherein the at least one heating element is energized to generate heat and a zero-power level wherein the at least one heating element is not energized. The cooking appliance further includes a temperature sensor configured to detect a temperature or rate of temperature change of a cooking element. The cooking appliance further includes a control device configured to adjust the at least one heating element from the working-power level to the zero-power level based on the temperature or rate of temperature change of the cooking element. The at least one heating element will remain at the zero-power level until a user intervenes to re-energize the at least one heating element.

Abstract: An internal combustion engine controller for controlling an internal combustion engine is provided. The internal combustion engine controller comprises a memory and a processor. The memory is configured to store a plurality of control maps, each control map defining a hypersurface of actuator setpoints for controlling an actuator of the internal combustion engine based on a plurality of input variables to the internal combustion engine controller. The processor comprises an engine setpoint module and a map updating module. The map updating module is configured to optimise one or more of the hypersurfaces of the control maps at the location defined by the plurality of input variables. The map updating module comprises an optimiser module configured to search for an optimised group of actuator setpoints wherein the map updating module updates the one or more hypersurfaces at the location defined by the plurality of input variables based on the optimised group of actuator setpoints.

Abstract: The present invention relates to a universal powertrain for controlling an effort request and/or a flow request to a powertrain based on a demanded effort or demanded flow for the powertrain. The universal controller includes a configurable powertrain model and a configurable optimiser module. The universal controller is configurable to control a class of generic powertrains comprising J generic power sources, K generic power sinks, and L generic couplings.

Abstract: A universal controller for a powertrain is provided. The universal controller comprises a configurable powertrain model which is configurable to model a class of generic powertrains comprising J generic power sources, K generic power sinks, and L generic couplings. The universal controller is arranged to receive an input file comprising a plurality of input parameters to configure the configurable powertrain model of the universal controller to control a specific powertrain having a powertrain architecture comprising N power sources, M power sinks, and X couplings. The configurable powertrain model is configured to model the specific powertrain based using N power source models, M power sink models, X coupling models, and a model architecture which may be defined from a generic powertrain component library and a connection parameter module.

Abstract: The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.