Abstract: The invention relates to a trypanosomalvaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination to prevent trypanosomal infection in a mammal.

Abstract: The invention relates to a trypanosomal vaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination to prevent trypanosomal infection in a mammal.

Abstract: The present invention relates to a trypanosomal vaccine comprising an FLA1 binding protein, as well as to pharmaceutical compositions comprising said vaccine and their uses in vaccination to prevent or treat trypanosomal infection in a mammal. Thus, also provided are a method of preventing or treating trypanosomal infection comprising administering said vaccine and a kit of parts comprising a medical instrument or other means for administering.

Abstract: The invention relates to a trypanosomal vaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination to prevent trypanosomal infection in a mammal.

Abstract: The invention relates to a trypanosomalvaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination to prevent trypanosomal infection in a mammal.

Abstract: A process for the preparation of a dispersion, comprising: dispersing a composition comprising a particulate solid, a liquid medium and a dispersant; wherein the dispersant is obtained by a process comprising at least the steps a) and b): a) co-polymerising a monomer composition comprising at least the components i) and ii) so as to form a phospho-ester functional polymer: i) a monomer having at least one phospho-ester group and two groups independently selected from hydroxyl, amino, thiol and hydrazo groups, ii) a diisocyanate; and b) hydrolysing at least some of the phospho-ester groups in the phospho-ester functional polymer so as to result in a dispersant having phosphorus containing anionic groups.

Abstract: A process for preparing a polymer comprising reacting at least the components i), ii) and optionally iii) to form a pre-polymer: i) a compound of the Formula (1); wherein: T1 and T2 are each independently HO—, HS— or HNR1—; Q1 and Q2 independently are —NR2—; A1 and A2 independently are an optionally substituted divalent organic linking group; Z is a halogen; R1 when present is H or an optionally substituted alkyl, aryl or heterocyclyl group; R2 is H or an optionally substituted alkyl, aryl or heterocyclyl group; ii) a diisocyanate; iii) optionally an isocyanate reactive compound; and then reacting the pre-polymer with at least component iv): iv) one or more compounds selected from an organic amine, alcohol or thiol provided that at least one of the organic compounds in component iv) has at least one ionic group.

Abstract: A process for preparing a polymer comprising reacting at least the components i) to iii) in any order: i) a compound of the Formula (1): Formula (1) wherein: T1 and T2 independently are HO—, HS— or R1HN—; Q1 and Q2 independently are —NR2—; A1 and A2 independently are an optionally substituted divalent organic linking group; R1 when present is H or an optionally substituted alkyl, aryl or heterocyclyl group; R2 is H or an optionally substituted alkyl, aryl or heterocyclyl group; Z is an HO— group or a group of the Formula (2) or (3); Formula (2) wherein: L is —HN—, —O— or —S—; X is an optionally substituted organic group; Formula (3) wherein: each X independently is an optionally substituted organic group; in both Formulae (2) and (3) the asterisk (*) signifies the point of attachment to the triazine ring: ii) a diisocyanate; iii) an isocyanate reactive compound having at least one ionic group.

Abstract: A process for preparing a polymer comprising reacting at least the components i), ii) and optionally iii) to form a pre-polymer: i) a compound of the Formula (1); wherein: T1 and T2 are each independently HO—, HS— or HNR1—; Q1 and Q2 independently are —NR2—; A1 and A2 independently are an optionally substituted divalent organic linking group; Z is a halogen; R1 when present is H or an optionally substituted alkyl, aryl or heterocyclyl group; R2 is H or an optionally substituted alkyl, aryl or heterocyclyl group; ii) a diisocyanate; iii) optionally an isocyanate reactive compound; and then reacting the pre-polymer with at least component iv): iv) one or more compounds selected from an organic amine, alcohol or thiol provided that at least one of the organic compounds in component iv) has at least one ionic group.

Abstract: A process for preparing a polymer comprising reacting at least the components i) to iii) in any order: i) a compound of the Formula (1): Formula (1) wherein: T1 and T2 independently are HO—, HS— or R1HN—; Q1 and Q2 independently are —NR2—; A1 and A2 independently are an optionally substituted divalent organic linking group; R1 when present is H or an optionally substituted alkyl, aryl or heterocyclyl group; R2 is H or an optionally substituted alkyl, aryl or heterocyclyl group; Z is an HO— group or a group of the Formula (2) or (3); Formula (2) wherein: L is —HN—, —O— or —S—; X is an optionally substituted organic group; Formula (3) wherein: each X independently is an optionally substituted organic group; in both Formulae (2) and (3) the asterisk (*) signifies the point of attachment to the triazine ring: ii) a diisocyanate; iii) an isocyanate reactive compound having at least one ionic group.

Abstract: A process for the preparation of a dispersion, comprising: dispersing a composition comprising a particulate solid, a liquid medium and a dispersant; wherein the dispersant is obtained by a process comprising at least the steps a) and b): a) co-polymerising a monomer composition comprising at least the components i) and ii) so as to form a phospho-ester functional polymer: i) a monomer having at least one phospho-ester group and two groups independently selected from hydroxyl, amino, thiol and hydrazo groups, ii) a diisocyanate; and b) hydrolysing at least some of the phospho-ester groups in the phospho-ester functional polymer so as to result in a dispersant having phosphorus containing anionic groups.

Abstract: A dispersion comprising a particulate solid, a liquid vehicle and a first polymer, wherein: the first polymer is obtained or obtainable by a process comprising reacting at least the components i), ii) and optionally iii) to form a pre-polymer: i) a compound of the Formula (1); wherein T1, T2, Q1, Q2, A1, A2 and Z are as defined in claim 1; ii) a diisocyanate; iii) an isocyanate-reactive compound; and then reacting the pre-polymer with at least component iv): iv) one or more compounds selected from an organic amine, alcohol or thiol provided that at least one of the said one or more organic compounds in component iv) has at least one ionic group; wherein the particulate solid is surface-modified with ionic groups and/or the particulate solid has situated on its surface one or more second polymers which is/are different from the first polymer.

Abstract: Several preferred embodiments are disclosed for a tool-less blade clamping apparatus for a reciprocating tool of the type which has a reciprocating plunger which has a tool attachment receiving slot for receiving a tool attachment of the type that has a shank portion. The clamping apparatus has an unclamped position and a clamped position. In the unclamped position, a tool attachment can be easily inserted and when it is in its clamped position, the tool attachment is securely retained. The preferred embodiments have at least one spring biasing the apparatus toward the clamped position, a releasable retaining mechanism for holding the apparatus in its unclamped position after being placed in that position. When the blade shank portion is inserted into the slot a predetermined distance, the shoulders of the shank portion release the retaining mechanism to move it to its clamped position.

Abstract: Several preferred embodiments are disclosed for a tool-less blade clamping apparatus for a reciprocating tool of the type which has a reciprocating plunger which has a tool attachment receiving slot for receiving a tool attachment of the type that has a shank portion. The clamping apparatus has an unclamped position and a clamped position. In the unclamped position, a tool attachment can be easily inserted and when it is in its clamped position, the tool attachment is securely retained. The preferred embodiments have at least one spring biasing the apparatus toward the clamped position, a releasable retaining mechanism for holding the apparatus in its unclamped position after being placed in that position. When the blade shank portion is inserted into the slot a predetermined distance, the shoulders of the shank portion release the retaining mechanism to move it to its clamped position.

Abstract: An oligomerised dye compound, and salts thereof, obtainable by a process which comprises reacting a compound of Formula (1) and salts thereof with a compound of Formula (2) and salts thereof wherein: R1 and R2 are independently H, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R3 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; X and Y are independently a substituent; a+b=0 to 4; n=1 to 6; L-(NH2)m??Formula (2) wherein: L comprises an optionally substituted, or optionally interrupted, aliphatic group, an optionally substituted aromatic group or an optionally substituted heterocyclic group; and m is 2 to 4. Also compositions, inks, printing processes, printed materials and ink jet cartridges.

Abstract: A compound of Formula (1) and salts thereof: wherein: R1 and R2 are independently H or optionally substituted C1-4alkyl; R3 is optionally substituted aryl or optionally substituted heteroaryl; X and Y are independently an acetyl group, an acetate ester group, a carbonamide group, a sulfoxide group, a sulfone group, a phosphonate group, a nitro group, a nitrile group, an isonitrile group, a quaternary amine, a carbonyl group (other than a carboxylic acid), a polyhaloalkyl group or a halogen atom; a+b=0 to 4; and n=1 to 6. Also ink-jet compositions, processes and cartridges and printed material.

Abstract: A compound of Formula (1) and salts thereof: wherein: R1 and R2 are independently H or optionally substituted C1-4alkyl; R3 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R4 and R5 are independently H, optionally substituted alkyl optionally substituted aryl or optionally substituted heteroaryl with the proviso that R4 and R5 do not carry a carboxylic acid substituent; X and Y are independently an acetyl group, an acetate ester group, an amide group, a sulfoxide group, a sulfone group, a phosphonate group, a nitro group, a nitrile group, an isonitrile group, a quaternary amine, a carbonyl group (other than a carboxylic acid), a polyhaloalkyl group or a halogen atom; a+b=0 to 4; n=1 to 6; and m is greater than 0: provided that the compounds of Formula (1) contain at least one substituent selected from the group consisting of —SO3H and —PO3H2. Also compositions, inks, printing processes, printed materials and ink-jet cartridges.

Abstract: A compound of Formula (1) and salts thereof: wherein: A is optionally substituted heterocyclyl; X is N or C—CN; R1 is H or a substituent; R2 and R3 are independently H, optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocyclyl or —SO2R4, wherein R4 is optionally substituted optionally substituted aryl or optionally substituted heterocyclyl; and provided that the compound of Formula (1) has attached, either directly or through a substituent, at least one ionic water solubilising group selected from the group consisting of CO2H, COSH, SO3H and PO3H2. Also compositions, inks, ink-jet printing processes, printed materials and ink-jet cartridges.

Abstract: A process for printing an image on a substrate comprising applying to the substrate an ink comprising a medium and compound of Formula (1) or a salt thereof wherein the compound of Formula (1) or a salt thereof is a triazine coupled azo containing colorant. The process and colorant are especially useful for ink jet printing.

Abstract: Several preferred embodiments are disclosed for a tool-less blade clamping apparatus for a reciprocating tool of the type which has a reciprocating plunger which has a tool attachment receiving slot for receiving a tool attachment of the type that has a shank portion. The clamping apparatus has an unclamped position and a clamped position. In the unclamped position, a tool attachment can be easily inserted and when it is in its clamped position, the tool attachment is securely retained. The preferred embodiments have at least one spring biasing the apparatus toward the clamped position, a releasable retaining mechanism for holding the apparatus in its unclamped position after being placed in that position. When the blade shank portion is inserted into the slot a predetermined distance, the shoulders of the shank portion release the retaining mechanism to move it to its clamped position.